Search results for "ETIOLOGY"
showing 9 items of 639 documents
A common biological basis of obesity and nicotine addiction
2013
Contains fulltext : 128630.pdf (Publisher’s version ) (Open Access) Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked …
Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity
2021
Centrioles comprise the heart of centrosomes, microtubule-organizing centers. To study the function of centrioles in lung and gut development, we genetically disrupted centrioles throughout the mouse endoderm. Surprisingly, removing centrioles from the endoderm did not disrupt intestinal growth or development but blocked lung branching. In the lung, acentriolar SOX2-expressing airway epithelial cells apoptosed. Loss of centrioles activated p53, and removing p53 restored survival of SOX2-expressing cells, lung branching, and mouse viability. To investigate how endodermal p53 activation specifically killed acentriolar SOX2-expressing cells, we assessed ERK, a prosurvival cue. ERK was active t…
Laser guns and hot plates
2005
Common variants at VRK2 and TCF4 conferring risk of schizophrenia
2011
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants show…
Consensus nomenclature for CD8(+) T cell phenotypes in cancer
2015
International audience; Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T…
Uso de las coronas telescópicas en el tratamiento de un paciente adulto con fisura labiopalatina: Puesta al día de la etiología y el tratamiento
2006
La fisura labiopalatina es una de las malformaciones congénitas craneofaciales más importantes a tener en cuenta por el odontólogo general debido a su alta incidencia y a su elevada repercusión en la cavidad oral. Sus causas se deben a factores genéticos y predominantemente a factores ambientales, haciendo su aparición ya en el período embrionario. El sexo masculino se encuentra más afectado, en una relación de 7:3. La asociación más frecuente es el labio leporino unilateral total con fisura palatina, que es el caso que nos atañe. Presentamos el caso de un varón de 20 años que acude a nuestra consulta demandando una solución estética a su situación dental. El tratamiento efectuado al pacien…
O zagrożeniu wypaleniem zawodowym nauczycieli wczesnej edukacji
2018
Nauczyciele stanowią jedną z tych grup zawodowych, które poddane są szczególnej kontroli społecznej, co ma związek z charakterem wykonywanej pracy. Odpowiedzialność za kształcenie i wychowanie przyszłych pokoleń, chęć sprostania oczekiwaniom rodziców a także wymaganiom stawianym przez nadzór pedagogiczny stwarza sytuację, w której osoby mniej odporne na stres narażone są ha różne konsekwencje. Od osób wykonujących zawód nauczyciela zawsze wymagano wiele. Poza niezbędnymi kompetencjami merytorycznymi, metodycznymi, psychologicznymi czy społecznymi, oczekiwano mądrości życiowej, odpowiedzialności, autentyczności, zaangażowania, poświęcenia, altruizmu, kreatywności i wielu innych cech sprzyjaj…
Relationships Between Health Promoting Activities, Life Satisfaction, and Depressive Symptoms in Unemployed Individuals
2021
Background: Previous research has documented that unemployed individuals who engage in recreational activities, either alone or with others, experience higher levels of mental health and psychological well-being relative to those who do not engage in recreational activities. Aims: In this study, we examined whether engagement in health promoting activities, alone or with other family members, is associated with reduced levels of depression and enhanced levels of life satisfaction in unemployed individuals. Method: We employed a cross-sectional design in which we measured life satisfaction, depressive symptoms, consumption of healthy meals and engagement in physical activities in 203 unemplo…
Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B Cells.
2022
Upon infection, viruses hijack the cell machinery and remodel host cell structures to utilize them for viral proliferation. Since viruses are about a thousand times smaller than their host cells, imaging virus-host interactions at high spatial resolution is like looking for a needle in a haystack. Scouting gross cellular changes with fluorescent microscopy is only possible for well-established viruses, where fluorescent tagging is developed. Soft X-ray tomography (SXT) offers 3D imaging of entire cells without the need for chemical fixation or labeling. Here, we use full-rotation SXT to visualize entire human B cells infected by the herpes simplex virus 1 (HSV-1). We have mapped the temporo…