Search results for "EXPANSION"
showing 10 items of 630 documents
Genetic and Chemical Modifiers Of A CUG Toxicity Model in Drosophila
2007
Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context of a non-translatable RNA. These flies reproduced aspects of the DM1 pathology, most notably nuclear accumulation of CUG transcripts, muscle degeneration, splicing misregulation, and diminished Muscleblind function in vivo. Reduced Muscleblind activity was evident from the sensitivity of CUG-induced phenotypes to a decrease in muscleblind genetic dosage and rescue by MBNL1 expression, and furthe…
In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models
2011
6 pages, 5 figures. PMID:21730182[PubMed] PMCID: PMC3141925[Available on 2012/1/19]
Correction: Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotoni…
2018
ABSTRACT Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant myotonin-protein kinase (DMPK) transcripts containing expanded CUG repeats. Pathogenic DMPK RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations in metabolism of various RNAs. Cardiac dysfunction represents the second most common cause of death in DM type 1 (DM1) patients. However, the contribution of MBNL sequestration in DM1 cardiac dysfunction is unclear. We overexpressed Muscleblind (Mbl), the Drosophila MBNL orthologue, in cardiomyocytes of DM1 model flies and observed a rescue of heart dysfunctions, which are characteristic of these model flies and resem…
Regional Policy Lessons from Finland
2005
The Finnish economy and society has long been dominated by primary production. Post-war economic development was rapid and welfare gaps between the much more developed economies and Finland narrowed and were even partly reversed. Rapid economic expansion together with structural change has had the effect of centralizing both economic activity and population. The trend has been towards the southern and central regions where the metropolitan area of Helsinki and most of the other larger towns and urban centres are located. Together with vigorous technological progress in agriculture and forestry the rapid urbanization and industrialization of the 1960s and 1970s the fastest in Europe altered …
The importance of Hygienics and Clean Water Treatment in Valencia (1860-1910)
2016
El siglo XIX se caracteriza por numerosos cambios tanto a nivel social como estructural de la población: se produce un acelerado desarrollo urbano sin planificación y carente de servicios que da lugar a una mala calidad de vida y numerosas epidemias. Estos cambios tienen como resultado un nuevo movimiento, el Higienismo, que pretende mejorar las condiciones de vida de la población. En España, todas las reformas higiénicas se desarrollaron mediante los planes de Ensanche. Uno de los puntos clave de este pensamiento es el abastecimiento de agua potable como medio para evitar enfermedades. La ciudad de Valencia es un claro ejemplo de la importancia de este movimiento y cómo el abastecimiento d…
Complete One-Loop Renormalization of the Higgs-Electroweak Chiral Lagrangian
2018
The electroweak sector of the Standard Model can be formulated in a way similar to Chiral Perturbation Theory (ChPT), but extended by a singlet scalar. The resulting effective field theory (EFT) is called Higgs-Electroweak Chiral Lagrangian (EWCh$\mathcal{L}$) and is the most general approach to new physics in the Higgs sector. It solely assumes the pattern of symmetry breaking leading to the three electroweak Goldstone bosons (i.e. massive $W$ and $Z$) and the existence of a Higgs-like scalar particle. The power counting of the EWCh$\mathcal{L}$ is given by a generalization of the momentum expansion of ChPT. It is connected to a loop expansion, making the theory renormalizable order by ord…
Benchmark study of undrained triaxial testing of Opalinus Clay shale: Results and implications for robust testing
2021
Triaxial testing of argillaceous rocks and shales is significantly more challenging than conventional rock mechanical testing. The challenges are mainly related to the very low permeability of these geomaterials, and their sensitivity to exposure of atmosphere and brines, which induces variations of water content, suction and effective stress. There are currently no international standards to guide service laboratories for robust testing procedures for shales. A benchmark study of undrained triaxial testing was therefore initiated with three leading service laboratories in shale testing, performing 13 tests and using two different methods of establishing sample saturation prior to deformati…
Radikalizācijas ekonomiskās sekas
2019
Finanšu un ekonomiskā krīze, pēdējā laikā notikusī nekontrolētā migrācija un teroristu uzbrūkumi izraisa politisko radikalizāciju dažās valstīs. Šajā pētījumā tiek aplūkoti augošā populisma un radikalizācijas ekonomiskie iemesli un sekas, kā arī ārējie un iekšējie ierobežojumi, vērsti uz negatīvo ekonomisko seku mazināšanu. Lai ilustrētu un pamatotu konstatējumus, tiks analizēti trīs gadījumi: nesenās politiskās radikalizācijas iemesli un sekas Grieķijā, Itālijā un ASV. Īpaša uzmanība tiek pievērsta ekspansīvajai fiskālajai politikai un protekcionisma politikai. Mēs pieņemam, ka populismam un radikalizācijai ir negatīva ietekme uz tautsaimniecību, vienlaikus valdības īsteno ekspansīvo fiskā…
Analysis of the use of expansion osteotomes for the creation of implant beds. Technical contributions and review of the literature.
2006
La atrofia ósea severa del maxilar superior compromete e incluso, en ocasiones, impide la colocación de implantes. Con la expansión ósea mediante osteodilatadores se evita usar instrumentos rotatorios, no se produce calor ni se elimina hueso y se simplifica el tratamiento quirúrgico permitiendo la colocación de fijaciones sin recurrir a tratamientos más complejos. Presentamos una revisión de la técnica de expansión maxilar mediante osteodilatadores, describiendo las principales indicaciones, ventajas e inconvenientes de este procediminiento quirúrgico. Sometimes, the severe superior maxillary atrophy compromises and even impide oral implants treatment. The use of rotatory instruments (drill…
The non-Gaussian distribution of galaxies gravitational fields
2016
We perform a theoretical analysis of the observational dependence between angular momentum of the galaxy clusters and their mass (richness), based on the method introduced in our previous paper. For that we obtain the distribution function of astronomical objects (like galaxies and/or smooth halos of different kinds) gravitational fields due to their tidal interaction. Within the statistical method of Chandrasekhar we are able to show that the distribution function is determined by the form of interaction between objects and for multipole (tidal) interaction it is never Gaussian. Our calculation permits to demonstrate how the alignment of galaxies angular momenta depend on the cluster richn…