Search results for "Eating"
showing 10 items of 1247 documents
Inulin Derivatives Obtained <i>Via</i> Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery
2015
A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…
Die Hemmung der Aufnahme vonα-Methylnoradrenalin in das Herz durch sympathomimetische Amine
1965
Hearts of rabbits were isolated and perfused with Tyrode solution containing 10 ng/ml (−)-α-methyl noradrenaline. The uptake by the heart ofα-methyl-noradrenaline was calculated by estimating the amount of amine removed from the perfusion fluid while passing through the heart. In control experiments the mean removal ofα-methyl noradrenaline was 43,7 ± 1,6% of the amount infused. The rate of removal remained constant throughout the time period of the experiment, i.e. 20 min.
Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities
2007
This review describes simple and useful concepts for predicting and tuning the pK(a) values of basic amine centers, a crucial step in the optimization of physical and ADME properties of many lead structures in drug-discovery research. The article starts with a case study of tricyclic thrombin inhibitors featuring a tertiary amine center with pK(a) values that can be tuned over a wide range, from the usual value of around 10 to below 2 by (remote) neighboring functionalities commonly encountered in medicinal chemistry. Next, the changes in pK(a) of acyclic and cyclic amines upon substitution by fluorine, oxygen, nitrogen, and sulfur functionalities, as well as carbonyl and carboxyl derivativ…
Phase Transition in Niobophosphate Glass-Ceramic
2011
Phase transition during crystallization of glass to glass-ceramic in system P2O5-CaO-Nb2O5-Na2O was studied. Several heating rates were compared – 1, 2, 5, 11 and 20°Cmin-1. DTA, XRD, FTIR and Raman analyses were performed. Niobophosphate glass-ceramic is found to form utterly different crystalline phases depending on maximal heating temperature, heating rate and time of maximal temperature maintenance. Crystallization temperatures of the same phases are strongly dependent on heating rate, while crystallinity of obtained phases is not. At lower temperatures poorly crystalline phosphates (Ca3(PO4)2, Ca10Na(PO4)7, Ca2P2O7) and niobates (NaNbO3 and Nb2O5) are identified. At higher temperatures…
Impulsivity and physical activity: A T-Pattern detection of motor behavior profiles.
2020
The relation between impulsivity and physical activity has been scantly investigated. Actually, during physical activity, several goals are achieved on the basis of a certain dose of impulsiveness. This study detects motor and interactive behavior profiles from athletes with traits of impulsiveness, moderate impulsiveness and non-impulsiveness, performing open motor tasks concerning material, space and interaction behaviors. A specific test was administered to assess the impulsivity profiles of athletes; then the Observational System of Motor Skills, Space, Time and Interaction (OSMOSTI), was used to observe and detect movement sequences patterns throughout T-Pattern detection and analysis …
Reconnection nanojets in the solar corona
2020
P.A. acknowledges STFC support from grant numbers ST/R004285/2 and ST/T000384/1 and support from the International Space Science Institute, Bern, Switzerland to the International Teams on ‘Implications for coronal heating and magnetic fields from coronal rain observations and modeling’ and ‘Observed Multi-Scale Variability of Coronal Loops as a Probe of Coronal Heating’. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 647214). P.T. was also supported by contracts 8100002705 and SP02H1701R from Lockheed-Martin to the Smithsonian Astrophysical Observatory (SAO), and NASA c…
On the Coronal Temperature in Solar Microflares
2020
We present a study of solar imaging and spectral observations of a microflare, focusing on the temperature diagnostics provided by the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory, and the Extreme-Ultraviolet Imaging Spectrometer (EIS) on board Hinode. Our data analysis, in particular from the emission in the 131 and 94 Å channels, indicates that the heated plasma reaches temperatures of ≿10 MK, at odds with a previous analysis of the same event, and we discuss the reason for the discrepancy. A particularly interesting aspect is the likely presence of the Fe XXIII 263.76 Å line, though weak, in EIS spectra in the early phases of the event, supporting the presen…
Modeling a coronal loop heated by magnetohydrodynamic turbulence nanoflares
2005
We model the hydrodynamic evolution of the plasma confined in a coronal loop, 30,000 km long, subject to the heating of nanoflares due to intermittent magnetic dissipative events in the MHD turbulence produced by loop footpoint motions. We use the time-dependent distribution of energy dissipation along the loop obtained from a hybrid shell model, occurring for a magnetic field of about 10 G in the corona; the relevant heating per unit volume along the loop is used in the Palermo-Harvard loop plasma hydrodynamic model. We describe the results, focusing on the effects produced by the most intense heat pulses, which lead to loop temperatures between 1 and 1.5 MK.
Direct measurement of the electron‐phonon relaxation rate in thin copper films
2004
We have used normal metal-insulator-superconductor (NIS) tunnel junction pairs, known as SINIS structures, for ultrasensitive thermometry at sub-Kelvin temperatures. With the help of these thermometers, we have developed an ac-technique to measure the electron-phonon (e-p) scattering rate directly, without any other material or geometry dependent parameters, based on overheating the electron gas. The technique is based on Joule heating the electrons in the frequency range DC-10 MHz, and measuring the electron temperature in DC. Because of the nonlinearity of the electron-phonon coupling with respect to temperature, even the DC response will be affected, when the heating frequency reaches th…
Electron-phonon interaction in thin copper and gold films
2004
We have studied the electron-phonon (e-p) interaction in thin Cu and Au films at sub-Kelvin temperatures with the help of the hot electron effect, using symmetric normal metal-insulator-superconductor tunnel junction pairs as thermometers. By Joule heating the electron gas and measuring the electron and the lattice temperatures simultaneously, we show that the electron-phonon scattering rate follows a $T^{4}$ temperature dependence in both metals. The result is in accordance with the theory of e-p scattering in disordered films with vibrating boudaries and impurities, in contrast to the $T^{3}$-law expected for pure samples, and $T^{2}$-law for static disorder.