Search results for "Eating"

Ultra-small gold nanoclusters assembled on plasma polymer-modified zeolites: a multifunctional nanohybrid with anti-haemorrhagic and anti-inflammator…

2021

Refereed/Peer-reviewed Hemostatic agents are pivotal for managing clinical and traumatic bleeding during emergency and domestic circumstances. Herein, a novel functional hybrid nanocomposite material consisting of plasma polymer-modified zeolite 13X and ultra-small gold nanoclusters (AuNCs) was fabricated as an efficient hemostatic agent. The surface of zeolite 13X was functionalised with amine groups which served as binding sites for carboxylate terminated AuNCs. Protein corona studies revealed the enhanced adsorption of two proteins, namely, coagulation factors and plasminogen as a result of AuNCs immobilization on the zeolite surface. The immune response studies showed that the hybrid na…

Study of thermal properties of polyethylene and polypropylene nanocomposites with long alkyl chain-substituted POSS fillers

2016

The effect of incorporation of octakis({alkyl}dimethylsiloxy)octasilsesquioxanes molecules with n-octyl, n-octadecyl and 4-methyl-hexyl substituents on thermal properties of polypropylene (PP), low-density polyethylene (LDPE) and high-density polyethylene (HDPE) was investigated. Thermal properties of those composite materials were evaluated by means of the differential scanning calorimetry (DSC) and thermogravimetric analysis (TG) methods. The type and mass% content of POSS nanofillers influenced the crystallization and melting properties as well as thermal stability of the obtained polyolefin nanocomposites. The incorporated POSS particles—acting as nucleating agents—improved the crystall…

Zn-Enhanced Asp-Rich Antimicrobial Peptides N-Terminal Coordination by Zn(II) and Cu(II), Which Distinguishes Cu(II) Binding to Different Peptides

2021

The antimicrobial activity of surfactant-associated anionic peptides (SAAPs), which are isolated from the ovine pulmonary surfactant and are selective against the ovine pathogen Mannheimia haemolytica, is strongly enhanced in the presence of Zn(II) ions. Both calorimetry and ITC measurements show that the unique Asp-only peptide SAAP3 (DDDDDDD) and its analogs SAAP2 (GDDDDDD) and SAAP6 (GADDDDD) have a similar micromolar affinity for Zn(II), which binds to the N-terminal amine and Asp carboxylates in a net entropically-driven process. All three peptides also bind Cu(II) with a net entropically-driven process but with higher affinity than they bind Zn(II) and coordination that involves the N…

The Development of the Brief Eating Disorder in Athletes Questionnaire

2014

MARTINSEN, M., I. HOLME, A. M. PENSGAARD, M. K. TORSTVEIT, and J. SUNDGOT-BORGEN. The Development of the Brief Eating Disorder in Athletes Questionnaire. Med. Sci. Sports Exerc., Vol. 46, No. 8, pp. 1666–1675, 2014. Purpose: The objective of this study is to design and validate a brief questionnaire able to discriminate between female elite athletes with and without an eating disorder (ED). Methods: In phase I, 221 (89.5%) adolescent athletes participated in a screening including the Eating Disorder Inventory-2 (EDI2) and questions related to ED. All athletes reporting symptoms associated with ED (n = 96, 94.1%) and a random sample without symptoms (n = 88, 86.3%) attended the ED Examinatio…

Efficient Synthesis of Multifunctional Chelating Agents Based on Tetraazacycloalkanes

2018

An efficient route has been developed for the synthesis of multifunctional tetraazacycloalkanes (in particular 1,4,7,10-tetraazacyclotridecane) incorporating an aminomethyl pendant arm on the carbon skeleton. Starting from the appropriate C-functionalized bisaminal-protected intermediate, the target macrocycles were easily obtained by means of a step-by-step introduction of the desired functional groups onto the free primary amine group, followed by deprotection of the bisaminal intermediates. This straightforward and versatile synthetic approach paves the way for the design of a new family of multifunctional chelators.

Generation of 6,7-Dihydro-5H-1,3,4-thiadiazolo[3,2-a]pyridines — Unexpected Products in the Reaction of 5-Ethylthio-1,3,4-thiadiazole-2-amine and 3-(…

1998

Synthesis of C3/C1-Substituted Tetrahydroisoquinolines

2015

A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada scoparia leaves against a panel of human and parasitic proteases revealed an interesting activity profile of 2 towards human 20S proteasome. This outcome suggests that the 1,2,3,4-tetrahydroisoquinoline skeleton may be exploited as a template for the development of novel anticancer agents. In this article, we report the synthesis and chemical characterization of a new series of isosalsoline-type alkaloids (10-11) with variations at N2 and C3 positions with respect to the natural Compound 2, obtained by a synthetic strategy that involves the Bischler-Napieralski cyclization. The substrate for…

Mechanism of aminocarbene formation by nucleophilic attack on isocyanide ligands in platinum(II)2-pyrazyl and 4-pyridyl complexes

1997

Abstract The reactions of 2-pyrazyl and 4-pyridyl isocyanide complexes [Pt(CNC 6 H 11 )(C 4 H 3 N 2 - C 2 )(dppe)ClO 4 and [Pt(CNC 6 H 11 )(C 5 H 4 N- C 4 ) (dppe)]ClO 4 ( 1 ) with amines involving the formation of aminocarbene derivatives have been studied kinetically in 1,2-dichloroethane by UV—VIS techniques. The kinetics obey the simple second-order rate law rate = k 2 [ 1 ][amine]. Low activation enthalpies and highly negative activation entropies for the k 2 term are observed. A mechanism is proposed involving direct nucleophilic attack of the amine on the isocyanide carbon with concomitant proton transfer from the amine to the isocyanide nitrogen assisted by the heterocyclic nitrogen…

The interplay between emotion regulation, interpersonal problems and eating symptoms in individuals with obesity: A network analysis study

2023

Introduction: A complex and bidirectional relationship between eating and psychological symptoms in individuals with obesity has been proposed. This study aims to identify the specific processes playing a role in this association, using a data-driven approach. Methods: Two hundred ninety-four adults with obesity, including 106 (36 %) with binge-eating disorder, were consecutively admitted to a specialized public center. They completed self-report questionnaires to assess emotion regulation, interpersonal problems, self-esteem, binge-eating symptoms, and expectancies regarding eating behaviors. To assess the interplay among eating and psychological variables, a network analysis was used. The…

2005