Search results for "Endothelium."
showing 10 items of 748 documents
Nitroglycerin-Induced Endothelial Dysfunction and Tolerance Involve Adverse Phosphorylation and S -Glutathionylation of Endothelial Nitric Oxide Synt…
2011
Objective— Continuous administration of nitroglycerin (GTN) causes tolerance and endothelial dysfunction by inducing reactive oxygen species (ROS) production from various enzymatic sources, such as mitochondria, NADPH oxidase, and an uncoupled endothelial nitric oxide synthase (eNOS). In the present study, we tested the effects of type 1 angiotensin (AT 1 )-receptor blockade with telmisartan on GTN-induced endothelial dysfunction in particular on eNOS phosphorylation and S -glutathionylation sites and the eNOS cofactor synthesizing enzyme GTP–cyclohydrolase I. Methods and Results— Wistar rats were treated with telmisartan (2.7 or 8 mg/kg per day PO for 10 days) and with GTN (50 mg/kg per d…
Trentino iedzīvotāju radzenes centrālās daļas endotēlijs
2017
Bakalaura darbs uzrakstīts angļu valodā uz 30 lappusēm. Tas satur 18 attēlus, 8 tabulas un atsauces uz 23 literatūras avotiem. Pētījuma mērķis bija novērtēt tādu faktoru kā smēķēšana un kontaktlēcu lietošana ietekme uz radzenes endotēlija fizioloģiju. Metode: 45 pacientiem (vecumā no 29 līdz 58 gadiem) veikta aptauja par smēķēšanas ieradumiem un kontaktlēcu lietošanu. Ikvienam tika novērtēts endotēlijs, trīs reizes mērot ar Takagi 700GL spraugas lampu un EndoKer programmu. Rezultāti: Darbā netika atrasta nozīmīga korelācija starp dzimumu un vecuma grupām attiecībā uz kādu no ietekmes faktoriem. Kā arī nebija nozīmīga atšķirība starp smēķētājiem, kontaktlēcu lietotājiem un normālo populāciju…
Glycemic variability using 48-hour continuous glucose monitorin, endothelial function, and carotid intima-media thickness in the metabolic syndrome
2010
2014
Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resve…
Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results
2013
International audience; BACKGROUND: To evaluate whether abnormal endothelial function, a common finding in gestational diabetes mellitus (GDM) pregnancies, can be explained by inflammatory cytokines. METHODS: Forearm skin blood flow (FSBF), into response to acetylcholine (Ach) (endothelium-dependent vasodilatation), were measured in 24 pregnant control subjects and 28 gestational diabetes mellitus (GDM) women, in the third trimester of gestation. A fasting glycemic and lipidic panel was obtained, and inflammatory cytokines (TNF-alpha and IL-6) and adiponectin were also determined. RESULTS: FSBF is significantly reduced in GDM group compared with control subjects (344.59 +/- 57.791 vs.176.38…
Tenascin gene expression in rat liver and in rat liver cells. In vivo and in vitro studies.
1991
Tenascin is a major glycoprotein constituent of the extracellular matrix with a strong affinity to fibronectin; its distribution is believed to be temporarily and spatially limited. Tenascin gene expression is increased during wound healing processes. As repair mechanisms in chronic liver diseases resemble wound healing we studied tenascin gene expression in rat liver and in isolated rat liver cells. In normal rat liver a tenascin specific antiserum stains sinusoidal cells with fiber-like prolongations, which at the same time are desmin-positive (ITO-cells). In the CCl4-acutely-damaged liver a strong tenascin staining is detected in cells located among the mononuclear cells of the inflammat…
Intermittent hypobaric hypoxia applicability in myocardial infarction prevention and recovery.
2012
Abstract Intermittent hypobaric hypoxia (IHH) has been the focus of important research in cardioprotection, and it has been associated with several mechanisms. Intermittent hypobaric hypoxia inhibits prolyl hydroxylases (PHD) activity, increasing the stabilization of hypoxia-inducible factor-1 (HIF-1) and activating crucial adaptative genes. It has been hence suggested that IHH might be a simple intervention, which may offer a thoughtful benefits to patients with acute myocardial infarction and no complications. Nevertheless, several doubts exist as to whether IHH is a really safe technique, with little to no complications in post-myocardial infarction patients. Intermittent hypobaric hypox…
On the lymphocyte transendothelial migration at the level of absorbing lymphatic vessel of thymus-dependent lymphoid areas of Peyer's patches
2006
Análisis del perfil de expresión de microRNA en células endoteliales humanas expuestas a estradiol. Papel del miR-30b-5p en la regulación de la expre…
2017
El endotelio es un tejido dinámico que juega un papel fundamental en el mantenimiento de la función vascular. Está localizado en la capa interna de los vasos sanguíneos, linfáticos y corazón, y resulta clave para las diversas funciones del sistema cardiovascular, tales como la hemostasia, la regulación del tono vascular, la respuesta inflamatoria, la regulación de la permeabilidad vascular y la angiogénesis. El endotelio actúa como una diana de los estrógenos y expresa ambos tipos de receptores de estrógenos (ER): los nucleares clásicos ERα and ERβ, que actúan como factores de transcripción, y el receptor acoplado a proteína G (GPER). Mientras que la unión de estrógenos a ERα y ERβ modula l…
Estrogen Receptor and Vascular Aging.
2021
Cardiovascular diseases remain an age-related pathology in both men and women. These pathologies are 3-fold more frequent in men than in women before menopause, although this difference progressively decreases after menopause. The vasculoprotective role of estrogens are well established before menopause, but the consequences of their abrupt decline on the cardiovascular risk at menopause remain debated. In this review, we will attempt to summarize the main clinical and experimental studies reporting the protective effects of estrogens against cardiovascular diseases, with a particular focus on atherosclerosis, and the impact of aging and estrogen deprivation on their endothelial actions. Th…