Search results for "Engineering and Technology"
showing 10 items of 16184 documents
Comprehensive analysis of photoinitiators and primary aromatic amines in food contact materials using liquid chromatography High-Resolution Mass Spec…
2018
Abstract A comprehensive strategy for the analysis of UV-ink photoinitiators and primary aromatic amines (PAAS) in food-packaging materials such as, juice tetrabricks, pouches and bags has been developed using liquid chromatography coupled to Orbitrap High-Resolution Mass Spectrometry (LC-Orbitrap-HRMS). The methodology includes both quantitative target analysis and post-run target screening analysis. The quantitative method was validated after a previous optimisation of the single-stage Orbitrap fragmentation through the Higher-Energy Collisional Dissociation (HCD) Cell. Overall, the quantitative method presented recoveries ranging from 78% to 119%, with a precision (RSD) lower than 20%, f…
Loading and release of the complex [Pt(DTBTA)(DMSO)Cl]Cl·CHCl3 with the 2,2′-dithiobis(benzothiazole) ligand into mesoporous silica and studies of an…
2018
Abstract Synthetic delivery systems have great potential for overcoming problems associated with systemic toxicity that accompanies chemotherapy with the use of cisplatin and family of platinum anticancer drugs. Mesoporous silicates have been studied in context of drug delivery and drug targeting. In this paper we report the studies of loading and release of a platinum complex, [Pt(DTBTA)(DMSO)Cl]Cl∙CHCl3 (1) where DTBTA = 2,2′-dithiobis(benzothiazole), that was recently synthesized and structurally characterized. Evaluation in vitro of antitumor activity against a human breast cancer cell line (MCF-7) showed a very potent activity of complex(1). Therefore, we thought to incorporate this co…
Functionalized halloysite nanotubes: Efficient carrier systems for antifungine drugs
2018
Abstract Halloysite-cyclodextrin hybrid was employed as carrier for sustained release of clotrimazole for vaginal or buccal treatment of Candidiasis. The nanocarrier was obtained by functionalization of halloysite surface with cyclodextrin moieties by means of microwave irradiation, with the final goal to obtain a scaffold for the covalent linkage of cysteamine hydrochloride. The interaction between clotrimazole and the pristine components, namely cyclodextrin and halloysite, was thoroughly investigated by several techniques such as DSC, TGA, UV–vis spectroscopy and some adsorption studies were, also, carried out. The release of the antifungine molecule was finally investigated in a medium …
Self-assembled multivalent (SAMul) ligand systems with enhanced stability in the presence of human serum
2019
Self-assembled cationic micelles are an attractive platform for binding biologically-relevant polyanions such as heparin. This has potential applications in coagulation control, where a synthetic heparin rescue agent could be a useful replacement for protamine, which is in current clinical use. However, micelles can have low stability in human serum and unacceptable toxicity profiles. This paper reports the optimi- sation of self-assembled multivalent (SAMul) arrays of amphiphilic ligands to bind heparin in competitive conditions. Specifically, modification of the hydrophobic unit kinetically stabilises the self-assembled nanostructures, preventing loss of binding ability in the presence of…
NIR-absorbing transition metal complexes with redox-active ligands
2020
Bench top stable transition metal (M = Co, Ni, Cu) complexes with a non-innocent ortho-aminophenol derivative were synthesized by the reaction of metal(II)acetates with a ligand precursor in 2:1 ratio. The solid-state structures reveal the formation of neutral molecular complexes with square planar coordination geometries. The Co(II) and Cu(II) complexes are paramagnetic, whereas the Ni complex is a diamagnetic square planar low-spin Ni(II) complex. All complexes, and Ni(II) complex in particular, show strong absorption in the near-IR region. Peer reviewed
Rocking of rigid block on nonlinear flexible foundation
2017
Abstract The two prime models used currently to describe rocking of rigid bodies, the Housner’s model and the Winkler foundation model, can capture some of the salient features of the physics of this important problem. These two models involve either null or linear interaction between the block and the foundation. Hopefully, some additional aspects of the problem can be captured by an enhanced nonlinear model for the base-foundation interaction. In this regard, what it is adopted in this paper is the Hunt and Crossley’s nonlinear impact force model in which the impact/contact force is represented by springs in parallel with nonlinear dampers. In this regard, a proper mathematical formulatio…
Two-Dimensional Numerical Modelling of a Moored Floating Body under Sloping Seabed Conditions
2020
A coupled floating body-mooring line model is developed by combining a boundary element model for a two-dimensional floating body and a catenary mooring line model. The boundary element model is formulated in the time domain by a continuous Rankine source, and a reflection potential is introduced to account for the wave reflection due to sloping seabed. This newly developed model is validated by comparisons against available data. Then, dynamic response analyses are performed for the moored body in various seabed conditions. Compared with a flat seabed, a sloping seabed causes unsymmetrical mooring line configuration and generates noticeable effects in the motion responses of the floating b…
Konforme Abbildung und Greensche Funktion
1949
Mit Hilfe des Additionstheorems Gl. (I, 31) und mit Hilfe der imaginaren Transformation von Jacobi Gl. (I, 33) folgt fur die durch die Funktion λ = sn (z, k) vermittelte, Abbildung der z-Ebene auf die λ-Ebene $$\lambda = {\lambda _1} + i{\lambda _2} = snz = sn\left( {x + iy} \right) = \frac{{snxcniydniy + sniycnxdnx}}{{1 - {k^2}s{n^2}xs{n^2}iy}}$$ .
What a line can say : Investigating the semiotic potential of the connecting line in data visualizations
2020
The line is a graphical element widely used in data visualizations, its purpose often being to signal a connection between other visual elements. Based on social semiotic theory, this article investigates what semiotic functions connecting lines can have and how these functions can be related to variations in form. The results show that, in addition to the basic function of connecting elements, such lines can also indicate the level of certainty, direct the viewer to read the information either as a narrative or a conceptual claim, indicate patterns of cohesion, and regulate the viewer’s position. These findings allow for further empirical research on the formation of visual conventions.
Communication cost of channel estimation interpolation for group-based vehicular communications in cellular networks
2020
Las comunicaciones inalámbricas para aplicaciones vehiculares en sistemas celulares de quinta generación (5G) deben ser de baja latencia y alta fiabilidad. Entre otros factores, la cantidad de información de control que debe intercambiarse entre cada vehículo y la estación base puede penalizar la latencia de la comunicación. Varios casos de uso vehicular 5G implican comunicaciones dentro de grupos de vehículos, por ejemplo el pelotón de vehículos. Este trabajo se centra en explotar la estructura y características de este servicio vehicular particular basado en grupos para disminuir el intercambio de información de control relacionado con la etapa de estimación del canal necesaria para las c…