Search results for "Enone"
showing 10 items of 320 documents
Protective Effects of the Hydroethanolic Extract of Fridericia chica on Undifferentiated Human Neuroblastoma Cells Exposed to α-Zearalenol (α-ZEL) an…
2021
Fridericia chica (Bignoniaceae) is a traditional medicinal plant. The aim of this research was to determine the protective effects of the hydroethanolic extract from the F. chica leaves (HEFc) against the cytotoxicity of zearalenone (α-ZEL) and β-ZEL on SH-SY5Y cells. Free radical scavenging activity of HEFc was evaluated using the DPPH method. The cytotoxicity of both zearalenone metabolites and HEFc was examined using MTT test, as was the cytoprotective effects of the HEFc on cells treated with these mycotoxins. The chemical composition of HEFc was determined using UPLC-QTOF-MS/MS. HEFc elicited good DPPH radical scavenging activity following a concentration-dependent relationship. Cells …
Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity.
2009
Strong evidence indicates that oxidative stress may be causally involved in the pathogenesis of Parkinson's disease. We have employed human dopaminergic neuroblastoma cells and rat primary mesencephalic neurons to assess the protective potential of three novel bisarylimine antioxidants on dopaminergic cell death induced by complex I inhibition or glutathione depletion. We have found that exceptionally low concentrations (EC(50) values approximately 20 nM) of these compounds (iminostilbene, phenothiazine, and phenoxazine) exhibited strong protective effects against the toxicities of MPP(+), rotenone, and l-buthionine sulfoximine. Investigating intracellular glutathione levels, it was found t…
Monoterpene derivatives from the flowers of Ferulago campestris, (Apiaceae).
2013
Ferulago campestris (Besser) Grec., (Ferula galbanifera (Mill) Kock. = F. campestris), finocchiazzo, is an annual or perennial herb of the Mediterranean area. In this paper the phytochemical studies of the CH2Cl2 and MeOH extracts of the flowers are described. Several ferulol derivatives and a new 10-hydroxy-verbenone ester (7) were isolated. The structure of the new compound was established by extensive NMR analysis, including HMBC and HSQC pulse sequences.
Superoxide Flux in Endothelial Cells via the Chloride Channel-3 Mediates Intracellular Signaling
2007
Reactive oxygen species (ROS) have been implicated in both cell signaling and pathology. A major source of ROS in endothelial cells is NADPH oxidase, which generates superoxide (O2.−) on the extracellular side of the plasma membrane but can result in intracellular signaling. To study possible transmembrane flux of O2.−, pulmonary microvascular endothelial cells were preloaded with the O2.−-sensitive fluorophore hydroethidine (HE). Application of an extracellular bolus of O2.−resulted in rapid and concentration-dependent transient HE oxidation that was followed by a progressive and nonreversible increase in nuclear HE fluorescence. These fluorescence changes were inhibited by superoxide dism…
Recensione di Rossetti, L. Parmenide e Zenone sophoi ad Elea (2020)
2020
Recensione di Rossetti, L. Parmenide e Zenone sophoi ad Elea (2020).
The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis.
2012
In previous studies, we identified the fungal macrocyclic lactone (S)-curvularin (SC) as an anti-inflammatory agent using a screening system detecting inhibitors of the Janus kinase/signal transducer and activator of transcription pathway. The objective of the present study was to investigate whether SC is able to decrease proinflammatory gene expression in an in vivo model of a chronic inflammatory disease. Therefore, the effects of SC and dexamethasone were compared in the model of collagen-induced arthritis (CIA) in mice. Total genomic microarray analyses were performed to identify SC target genes. In addition, in human C28/I2 chondrocytes and MonoMac6 monocytes, the effect of SC on proi…
Deferiprone and idebenone rescue frataxin depletion phenotypes in a Drosophila model of Friedreich's ataxia
2013
Friedreich's ataxia (FRDA), the most common inherited ataxia, is a neurodegenerative disease caused by a reduction in the levels of the mitochondrial protein frataxin, the function of which remains a controversial matter. Several therapeutic approaches are being developed to increase frataxin expression and reduce the intramitochondrial iron aggregates and oxidative damage found in this disease. In this study, we tested separately the response of a Drosophila RNAi model of FRDA ( Llorens et al., 2007) to treatment with the iron chelator deferiprone (DFP) and the antioxidant idebenone (IDE), which are both in clinical trials. The FRDA flies have a shortened life span and impaired motor coord…
Zur Autoxydation von Polystyrol
1971
Die mit Azoisobuttersauredinitril (AIBN) initiierte Autoxydation von Polystyrol (PS) in Chlorbenzol bei 60°C ist von der Ordnung 0,75, bezogen auf AIBN, und 0,34, bezogen auf PS. Der niedrige Exponent der Polystyrolkonzentration weist neben intermolekularen Wachstumsschritten auf intramolekulare Reaktionsschritte bei der Autoxydation hin. Die bei der Autoxydation am Polystyrol gebildeten Hydroperoxidgruppen zerfallen in Essigsathylester als Losungsmittel mit einer Aktivierungsenthalpie von 19,7 kcal/Mol und einer Aktivierungsentropie von −29 cal/Mol Grad. Das spricht fur einen monomolekularen bifunktionellen Zerfallsmechanismus. Als fluchtige Produkte bei diesem Hydroperoxidzerfall werden P…
Über Umsetzungen an Poly-p-lithiumstyrol 2. Mitt. Derivate des poly-p-vinyl-di- und Triphenylmethans
1959
Das kurzlich von uns beschriebene Poly-p-lithiumstyrol stellt eine sehr reaktionsfahige makromolekulare metallorganische Verbindung dar. Es wird uber einige Umsetzungen mit Carbonylverbindungen berichtet. Die Reaktion mit Benzaldehyd und einigen p-substituierten Benzaldehyden fuhrt mit hohen Umsetzungsgraden zu Polyvinyldiphenylmethylcarbinolen. Die Reaktion mit Benzophenon liefert Polyvinyltriphenylmethylcarbinol. Diese Verbindung ist in konz. Schwefelsaure loslich als polymeres Analogon des Triphenylmethylkations, was aus der Untersuchung der Absorptionsspektren folgt. Mit MICHLERS Keton last sich ein polymeres Derivat des Malachitgruns darstellen, dessen spektroskopische, Untersuchung in…
Auxiliary-controlled stereoselective enolate protonation: Enantioselective synthesis of cis and trans annulated decahydroquinoline alkaloids
1998
Abstract The diastereoselective synthesis of the octahydroquinoline enone precursor of pumiliotoxin C is achieved via tandem Mannich-Michael reaction on N-galactosyl imines. Conjugate cuprate addition to the bicyclic enone stereoselectively forms the trans annulated 4a- epi -pumiliotoxin C skeleton in the presence of the carbohydrate auxiliary, and the cis annulated pumiliotoxin C skeleton in its absence.