Search results for "Envelope"
showing 10 items of 336 documents
Cloning and expression of the complement receptor glycoprotein C from Herpesvirus simiae (herpes B virus): protection from complement-mediated cell l…
2003
Simian herpes B virus (SHBV) is the herpes simplex virus (HSV) homologue for the species MACACA: Unlike in its natural host, and unlike other animal herpesviruses, SHBV causes high mortality in accidentally infected humans. SHBV-infected cells, like those infected with HSV-1 and equine herpesvirus types 1 and 4, express complement C3 receptor activity. To study immunoregulatory functions involved in susceptibility/resistance against interspecies transmission, the SHBV glycoprotein C (gC(SHBV)) gene (encoding 467 aa) was isolated. Sequence analysis revealed amino acid identity with gC proteins from HSV-2 (46.9 %), HSV-1 (44.5 %) and pseudorabies virus (21.2 %). Highly conserved cysteine resi…
Dense Bodies of Human Cytomegalovirus Induce both Humoral and Cellular Immune Responses in the Absence of Viral Gene Expression
2000
ABSTRACTInfection of fibroblast cell cultures with human cytomegalovirus (HCMV) leads to the production of significant amounts of defective enveloped particles, termed dense bodies (DB). These noninfectious structures contain major antigenic determinants which are responsible for induction of both the humoral and the cellular immune response against HCMV. We tested the hypothesis that, by virtue of their unique antigenic and structural properties, DB could induce a significant immune response in the absence of infectious virus. Mice were immunized with gradient-purified DB, which were either left untreated or subjected to sequential rounds of sonication and freeze-thawing to prevent cellula…
Alteration of nuclear (2'-5')oligoriboadenylate synthetase and nuclease activities preceding replication of human immunodeficiency virus in H9 cells.
1988
After infection of the respective target cells with the human immunodeficiency virus (HIV-1) viral progeny is produced only after a short temporary delay of some days, depending on cell type. After this period of time a sudden onset of HIV-1 protein synthesis with a dramatic increase in virus release occurs. (2'-5')Oligoriboadenylates [(2'-5')A], capable to activate a latent ribonuclease (RNase L) degrading both mRNA and rRNA, are known mediators involved in the early response of cells to virus infection. Here we show that the (2'-5')A-synthesizing (2'-5')A synthetase, which is inducible by interferon and activated by double-stranded RNA, as well as a (2'-5')A nuclease (2',3'-exoribonucleas…
Pre-stressed translucent panels made of innovative 3D glass components DSC-integrated, for safety and active building façades
2018
The widespread use of glazed envelopes, especially in high-rise buildings, is pushing building designers and researchers to the development of novel solutions for the improvement of their performance. At the University of Palermo, SBskin. Smart Building Skin s.r.l. (an innovative start up and academic spin off) is prototyping precast, pre- stressed and dry-assembled panels made of 3D glass subcomponents, able to reduce the energy consumption of buildings, to produce clean energy and to maintain high level of mechanical resistance against horizontal forces due to winds and earthquakes. The integration of glass subcomponents with third-generation PV technologies -Dye- Sensitized Solar Cells (…
The Bimodal Distribution in Exoplanet Radii: Considering Varying Core Compositions and $\rm H_{2}$ Envelope's Sizes
2020
Several models have been introduced in order to explain the radius distribution in exoplanet radii observed by Fulton et al. (2017) with one peak at $\rm \sim 1.3 R_{\oplus} $ the other at $\rm \sim 2.4 R_{\oplus} $ and the minimum at $\rm \sim 1.75R_{\oplus} $. In this paper we focus on the hypothesis that the exoplanet size distribution is caused by stellar XUV-induced atmospheric loss. We evolve $10^{6}$ synthetic exoplanets by exposing them to XUV irradiation from synthetic ZAMS stars. For each planet we set a different interior composition which ranged from $\rm 100 \: wt\%$ Fe (very dense) through $\rm 100 \: wt\%$ $\rm MgSiO_{3}$ (average density) and to $\rm 100 \: wt\%$ $\rm H_{2}O…
EPR on Radiation-Induced Defects in SiO2
2014
Continuous-wave electron paramagnetic resonance (EPR) spectroscopy has been the technique of choice for the studies of radiation-induced defects in silica (SiO2) for 60 years, and has recently been expanded to include more sophisticated techniques such as high-frequency EPR, pulse electron nuclear double resonance (ENDOR), and pulse electron spin echo envelope modulation (ESEEM) spectroscopy. Structural models of radiation-induced defects obtained from single-crystal EPR analyses of crystalline SiO2 (alfa-quartz) are often applicable to their respective analogues in amorphous silica (a-SiO2), although significant differences are common.
Pathways of Cell Infection by Parvoviruses and Adeno-Associated Viruses
2004
Animal viruses have developed various strategies for infecting cells, and all begin with adsorption to cell surface receptors, penetration into the cytosol, uncoating or release of the viral genome, and targeting the genome and any required accessory proteins toward the correct cellular organelle or compartment for replication (26, 48, 63). Since genome delivery and release require the rearrangement of the viral structures, infection is normally a multistep process involving various viral and cellular components. Viruses that replicate in the nucleus must have mechanisms for transporting the genome and other components to the vicinity of the nuclear pore and into the nucleus (84). The endos…
Innovative control logics for a rational utilization of electric loads and air-conditioning systems in a residential building
2015
The paper focuses on the evaluation of the impact on residential buildings of innovative control logics defined for a rational utilization of the electric loads and air-conditioning systems. The control logics are implementable thanks to a Decision Support and Energy Management Systems developed by the same authors and easily installable in new and still-existing houses. The paper shows how a significant reduction of the primary energy consumption can be obtained by controlling the air-conditioning units together with the other electric loads of the house. After having explained how the control logics operate, a simulation tool is described, developed for a preliminary evaluation of their e…
Analyses of innovative glass blocks for BIPV: assessment of thermal and optical performance
2015
This paper illustrates the results of the performance analyses conducted on an innovative glass block integrated with thirdgeneration dye-sensitised solar cells (DSCs), designed to enable the construction of translucent and sustainable building envelopes. The analyses include the simulation of both thermal and optical performance with regard to different configurations of the photovoltaic (PV)-integrated glass block, and the results obtained are presented using two different programs: Comsol Multiphysics and WINDOW. The configurations may differ – for example, because of the position of the module inside the glass block, the type of DSC module used (composition, transparency, design) and th…
Numerical Assessment of Heating Energy Demand for Office Buildings in Italy
2016
Abstract Buildings energy consumption depends on several parameters, such as climate, envelope typologies, occupant behavior, intended use, etc.; assessment of the energy performance of a building requires substantial input data describing constructions, environmental contexts, thermo-physical properties, geometry, control strategies and several other parameters influencing the thermal balance. In the last years, several numerical approaches dedicated to building simulation have been tested developing specialized software. On the other hand, simplified building models permit the evaluation of indoor conditions and heating/cooling loads with a good level of accuracy and without excessive com…