Search results for "Epidemiologic methods"

showing 10 items of 109 documents

Outcome of radical prostatectomy for incidental carcinoma of the prostate

2009

OBJECTIVE To evaluate a contemporary series of patients with incidental prostate cancer detected by transurethral resection of the prostate (TURP) and undergoing radical prostatectomy (RP). PATIENTS AND METHODS Between 1998 and 2004, 1931 patients had TURP for obstructive voiding symptoms and suspected BPH. Incidental prostate cancer was found in 104 (5.4%); 26 of these patients had a RP. The pathological staging and treatment of these patients were reviewed retrospectively and the follow-up results obtained. RESULTS Of the 26 patients who had RP, 17 had T1a and nine had T1b carcinoma of the prostate. After RP, six (35%) in the T1a group had no residual tumour (pT0) and 11 (65%) had pT2 can…

Malemedicine.medical_specialtyProstate biopsyUrologymedicine.medical_treatmentPathological stagingProstatic HyperplasiaUrologyurologic and male genital diseasesProstate cancerProstatemedicineHumansAgedTransurethral resection of the prostateProstatectomyIncidental Findingsmedicine.diagnostic_testbusiness.industryProstatectomyProstatic NeoplasmsCancerMiddle AgedProstate-Specific Antigenmedicine.diseaseTreatment Outcomemedicine.anatomical_structureHormonal therapyEpidemiologic MethodsbusinessProstatismBJU International
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Single-centre, triple-blinded, randomised, 1-year, parallel-group, superiority study to compare the effects of Roux-en-Y gastric bypass and sleeve ga…

2019

IntroductionBariatric surgery is increasingly recognised as an effective treatment option for subjects with type 2 diabetes and obesity; however, there is no conclusive evidence on the superiority of Roux-en-Y gastric bypass or sleeve gastrectomy. The Oseberg study was designed to compare the effects of gastric bypass and sleeve gastrectomy on remission of type 2 diabetes and β-cell function.Methods and analysisSingle-centre, randomised, triple-blinded, two-armed superiority trial carried out at the Morbid Obesity Centre at Vestfold Hospital Trust in Norway. Eligible patients with type 2 diabetes and obesity were randomly allocated in a 1:1 ratio to either gastric bypass or sleeve gastrecto…

Malemedicine.medical_specialtySleeve gastrectomyβ-cell functionmedicine.medical_treatment1843Gastric BypassBariatric Surgery030209 endocrinology & metabolismType 2 diabeteslaw.invention03 medical and health sciences0302 clinical medicineSuperiority TrialRandomized controlled trialClinical ProtocolslawGastrectomyDiabetes mellitusInternal medicineInsulin-Secreting CellsmedicineProtocolHumans030212 general & internal medicine1506VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771Glycated Hemoglobinbusiness.industryNorwayGeneral Medicinemedicine.diseaseRoux-en-Y anastomosismorbid obesityObesity MorbidDiabetes and EndocrinologyTreatment OutcomeDiabetes Mellitus Type 2GastrectomyFemaleLaparoscopytype 2 diabetesbusinessEpidemiologic MethodsBody mass indexrandomised controlled trialsleeve gastrectomy
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Expectations, experiences and attitudes of patients and primary care health professionals regarding online psychotherapeutic interventions for depres…

2013

Abstract Background In the year 2020, depression will cause the second highest amount of disability worldwide. One quarter of the population will suffer from depression symptoms at some point in their lives. Mental health services in Western countries are overburdened. Therefore, cost-effective interventions that do not involve mental health services, such as online psychotherapy programs, have been proposed. These programs demonstrate satisfactory outcomes, but the completion rate for patients is low. Health professionals’ attitudes towards this type of psychotherapy are more negative than the attitudes of depressed patients themselves. The aim of this study is to describe the profile of d…

Médicos de atención primariaPsychological interventionActitud ante los ordenadoresActitud ante la salud:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Attitude::Attitude to Computers [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]DepresionStudy ProtocolCompletion rateProtocol:Health Care::Health Care Quality Access and Evaluation::Delivery of Health Care::Attitude to Health [Medical Subject Headings]Depression (differential diagnoses)Qualitative Researcheducation.field_of_studyOnline psychotherapyEntrevistas como asuntoAttitude to ComputersDepressionGrupos focales:Health Care::Health Care Quality Access and Evaluation::Delivery of Health Care::Attitude of Health Personnel [Medical Subject Headings]TelemedicinaFocus GroupsTelemedicinePsychiatry and Mental health:Health Care::Health Services Administration::Patient Care Management::Delivery of Health Care::Telemedicine [Medical Subject Headings]Attitude to Healthmedicine.medical_specialtyTelemedicineAttitude of Health Personnel:Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychotherapy [Medical Subject Headings]PopulationInternet-based treatmentPhysicians Primary CareInterviews as TopicActitud del personal sanitariomedicineHumansPsychiatryeducationbusiness.industry:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Interviews as Topic::Focus Groups [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Interviews as Topic [Medical Subject Headings]:Health Care::Health Care Facilities Manpower and Services::Health Personnel::Physicians::Physicians Primary Care [Medical Subject Headings]:Disciplines and Occupations::Natural Science Disciplines::Science::Research::Empirical Research::Qualitative Research [Medical Subject Headings]Mental healthFocus groupPsychotherapyQualitative study:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression [Medical Subject Headings]businessQualitative research
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Implications of irradiating the subventricular zone stem cell niche

2016

Radiation therapy is a standard treatment for brain tumor patients. However, it comes with side effects, such as neurological deficits. While likely multi-factorial, the effect may in part be associated with the impact of radiation on the neurogenic niches. In the adult mammalian brain, the neurogenic niches are localized in the subventricular zone (SVZ) of the lateral ventricles and the dentate gyrus of the hippocampus, where the neural stem cells (NSCs) reside. Several reports showed that radiation produces a drastic decrease in the proliferative capacity of these regions, which is related to functional decline. In particular, radiation to the SVZ led to a reduced long-term olfactory memo…

NeurogénesisNeoplasias encefálicasCarcinogenesisSubventricular zoneNeurogenesis:Diseases::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms [Medical Subject Headings]Brain tumorSubventricular zoneBrain damageBiologyBrain tumorsArticle03 medical and health sciencesLateral ventricles0302 clinical medicineRadioterapiaLateral VentriclesGliomamedicineAnimalsHumans:Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms Nerve Tissue::Neuroectodermal Tumors::Neoplasms Neuroepithelial::Glioma [Medical Subject Headings]Stem Cell Nichelcsh:QH301-705.5:Anatomy::Cells::Stem Cells::Neural Stem Cells [Medical Subject Headings]Medicine(all)Neural stem cellsRadiationDentate gyrus:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Radiotherapy [Medical Subject Headings]NeurogenesisBrainCell BiologyGeneral MedicineAnatomymedicine.diseaseCélulas-madre neuralesNeural stem cellBrain tumormedicine.anatomical_structurelcsh:Biology (General)nervous system030220 oncology & carcinogenesis:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis::Disease-Free Survival [Medical Subject Headings]medicine.symptomNeuroscience030217 neurology & neurosurgeryDevelopmental BiologyStem Cell Research
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Clinical assessment of patients with advanced non-small-cell lung cancer eligible for second-line chemotherapy

2010

Purpose: Knowledge of prognostic factors for advanced non-small-cell lung cancer (NSCLC) patients eligible for second-line treatment is scarce. The aim of this study was to assess the prognostic role of a number of routinely collected clinical variables and to provide a summary index to discriminate patients according to probability of survival.Methods: individual data from nine randomised trials of second-line treatment in advanced NSCLC were analysed. Primary end-point was overall survival (OS). Cox model, stratified by trial, was used for multivariate analyses, and a prognostic index was provided and validated according to an internal/external procedure.Results: Out of 1239 patients, 119…

OncologyAdultMaleCancer Researchmedicine.medical_specialtyMultivariate analysisLung NeoplasmsWEEKLY DOCETAXELIRINOTECANCOMBINATION CHEMOTHERAPYAntineoplastic AgentsERLOTINIBPrognostic factorsNSCLCTHERAPYPooled analysisPLUS GEMCITABINEInternal medicineCarcinoma Non-Small-Cell LungAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansStage (cooking)Lung cancerEVERY 3 WEEKSAgedNeoplasm StagingRandomized Controlled Trials as TopicAged 80 and overPerformance statusProportional hazards modelbusiness.industryAge FactorsCombination chemotherapyPHASE-III TRIALMiddle Agedmedicine.diseasePrognosisTreatment OutcomeOncologyMeta-analysisPrognostic scoreCOMPARING DOCETAXELSecond-line treatmentAdenocarcinomaFemalebusinessEpidemiologic MethodsNon-small-cell lung cancerEuropean Journal of Cancer
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The lifelong risk of metachronous colorectal cancer justifies long-term colonoscopic follow-up.

2007

The aim of this study was to calculate the risk of metachronous colorectal cancers, to specify their characteristics and potential risk factors in a well-defined French population over a 27-year period.The 10,801 patients who had colorectal cancers totalled 61,879 person-years of follow-up. The actuarial method was used to obtain crude metachronous colorectal cancer rates. Standardised incidence ratios (SIRs) were calculated.The cumulative rate of metachronous colorectal cancer was 1.8% at 5 years, 3.4% at 10 years and 7.2% at 20 years. The incidence of metachronous colorectal cancer following a first colorectal cancer was higher than expected (SIR: 1.5 [1.3-1.7] p0.001). It remained greate…

OncologyMaleCancer Researchmedicine.medical_specialtyColorectal cancerPopulationColonoscopyGastroenterologyInternal medicineEpidemiologymedicineHumanseducationAgededucation.field_of_studymedicine.diagnostic_testPotential riskbusiness.industryIncidence (epidemiology)CancerNeoplasms Second PrimaryColonoscopymedicine.diseaseOncologyMulticenter studyFemaleFrancebusinessColorectal NeoplasmsEpidemiologic MethodsEuropean journal of cancer (Oxford, England : 1990)
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Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain

2011

Background: Evidence associating exposure to water disinfection by-products with reduced birth weight and altered duration of gestation remains inconclusive. Objective: We assessed exposure to trihalomethanes (THMs) during pregnancy through different water uses and evaluated the association with birth weight, small for gestational age (SGA), low birth weight (LBW), and preterm delivery. Methods: Mother–child cohorts set up in five Spanish areas during the years 2000–2008 contributed data on water ingestion, showering, bathing, and swimming in pools. We ascertained residential THM levels during pregnancy periods through ad hoc sampling campaigns (828 measurements) and regulatory data (264 me…

PediatricsFetus -- CreixementBathingHealth Toxicology and MutagenesisEspaña:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Cohort Studies:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models Theoretical [Medical Subject Headings]small for gestational agePregnancynewbornFemeninosExposición a Riesgos Ambientales:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]water pollutionInfeccions respiratòries -- EpidemiologiaAdultodisinfection by-products:Named Groups::Persons::Age Groups::Infant::Infant Newborn::Infant Low Birth Weight [Medical Subject Headings]Modelos TeóricosEnvironmental exposurepremature birthNacimiento PrematuroHumanos:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Logistic Models [Medical Subject Headings]Premature birthInfant Small for Gestational AgeGestation:Named Groups::Persons::Age Groups::Infant::Infant Newborn::Infant Low Birth Weight::Infant Small for Gestational Age [Medical Subject Headings]Femaleepidemiologymedicine.symptomAigua -- DepuracióAdultmedicine.medical_specialtytrihalomethanesContaminantes Químicos del AguaEmbarazoBirth weight:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]Embaràs -- Aspectes nutricionalsRecién nacidoRecién Nacido Pequeño para la Edad GestacionalEnvironmental healthmedicine:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]cohort studyModelos LogísticosHumanslow birth weightEpidemiologiaRecién Nacido de Bajo Peso:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons Halogenated::Trihalomethanes [Medical Subject Headings]Pregnancybusiness.industryTrihalometanoResearchPublic Health Environmental and Occupational HealthInfant Newbornbirth weightEnvironmental ExposureInfant Low Birth WeightModels Theoreticalmedicine.diseaseLow birth weightLogistic Models:Check Tags::Female [Medical Subject Headings]Spain:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings]Small for gestational age:Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants::Water Pollutants::Water Pollutants Chemical [Medical Subject Headings]:Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Obstetric Labor Complications::Obstetric Labor Premature::Premature Birth [Medical Subject Headings]businessEstudios de CohortesWater Pollutants Chemical
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Incidence of neuronal ceroid-lipofuscinoses in West Germany: Variation of a method for studying autosomal recessive disorders

1992

The incidence of neuronal ceroid-lipofuscinoses (NCL) in West Germany was determined using a novel method which is applicable to other autosomal recessively inherited diseases. Questionnaires were sent to all pediatric departments (answer rate 189/276, 68%), schools for the blind (39/46, 85%), and neuropathological institutes (15/22, 68%). Diagnoses were accepted only when based on firm clinical and/or electron microscopic criteria; 207 such identified patients were sorted according to year of birth. Plotting the cumulative number of new cases per year against the year of birth resulted in a slightly S-shaped curve. Before the year 1962, the curve is relatively flat, probably due to ineffic…

Pediatricsmedicine.medical_specialtyBatten diseasebusiness.industryIncidenceIncidence (epidemiology)Germany WestGenes Recessivemedicine.diseaseWest germanyNeuronal Ceroid-LipofuscinosesChild PreschoolEpidemiologyHumansMedicineNeuronal ceroid lipofuscinosisChildEpidemiologic MethodsbusinessElectron microscopicGenetics (clinical)Neuronal Ceroid-LipofuscinosesAmerican Journal of Medical Genetics
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Research Letter: is neuroticism a risk factor for postpartum depression?

2012

Although the relationship between personality and depressive illness is complex (Shea, 2005), there is empirical evidence that some personality features such as neuroticism, harm avoidance, introversion, dependency, self-criticism or perfectionism are related to depressive illness risk (Gunderson et al. 1999). Moreover, personality traits, especially neuroticism, may explain the increased prevalence of depression among females (Goodwin & Gotlib, 2004). Few studies have explored neuroticism, extraversion and psychoticism as risk factors for depression after an event as stressful as childbirth. Pitt (1968) was the first author to report high scores on neuroticism and low scores on extraversio…

Postpartum depressionNeurotic DisordersDepresión postpartoEvaluación de la personalidad:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]medicine.disease_causePersonality Assessment:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]PregnancyRisk Factors62P ApplicationsBig Five personality traits:Psychiatry and Psychology::Mental Disorders::Neurotic Disorders [Medical Subject Headings]Applied Psychology:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]education.field_of_studyPerfectionism (psychology)Middle AgedNeuroticismPsychiatry and Mental healthMathematical statistics:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Logistic Models [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]Harm avoidanceFemaleEstudios de seguimientoPsychology:Psychiatry and Psychology::Behavioral Disciplines and Activities::Personality Assessment [Medical Subject Headings]Factores de riesgoAdultmedicine.medical_specialtyAdolescent:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]PopulationEstadísticaDepression PostpartumYoung AdultPsychoticismCorrespondence:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings]medicine:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]Humans:Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychiatric Status Rating Scales [Medical Subject Headings]Escalas de valoración psiquiátricaPsychiatryeducationPsychiatric Status Rating ScalesExtraversion and introversion:Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària [Àrees temàtiques de la UPC]:Psychiatry and Psychology::Mental Disorders::Mood Disorders::Depressive Disorder::Depression Postpartum [Medical Subject Headings]medicine.diseaseLogistic Models:Check Tags::Female [Medical Subject Headings]Trastornos neuróticosFollow-Up Studies
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Residential Exposure to Outdoor Air Pollution during Pregnancy and Anthropometric Measures at Birth in a Multicenter Cohort in Spain

2011

Background: A growing body of research suggests that prenatal exposure to air pollution may be harmful to fetal development. We assessed the association between exposure to air pollution during pregnancy and anthropometric measures at birth in four areas within the Spanish Children’s Health and Environment (INMA) mother and child cohort study. Methods: Exposure to ambient nitrogen dioxide (NO2) and benzene was estimated for the residence of each woman (n = 2,337) for each trimester and for the entire pregnancy. Outcomes included birth weight, length, and head circumference. The association between residential outdoor air pollution exposure and birth outcomes was assessed with linear regress…

Questionnaires:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Environmental Monitoring [Medical Subject Headings]Fetus -- CreixementPediatricsHealth Toxicology and MutagenesisEspañaair pollution:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Cohort StudiesbenzenebirthRecién NacidoPregnancyResidence CharacteristicsSurveys and Questionnaires:Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants::Air Pollutants [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposure [Medical Subject Headings]Birth WeightBody SizeMedicineProspective StudiesProspective cohort studyTamaño Corporal:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings]Vehicle Emissions:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]Dióxido de NitrógenoPeso al NacerAir PollutantsInhalation ExposureanthropometryAdultoDistribución Espacial de la Población:Chemicals and Drugs::Complex Mixtures::Vehicle Emissions [Medical Subject Headings]Adulto JovenEstudios ProspectivosAire -- Contaminació -- Efectes fisiològics -- EpidemiologiaExposición MaternaHumanos:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Inhalation Exposure [Medical Subject Headings]Maternal ExposureFemeninaInfant Small for Gestational AgeCohort:Named Groups::Persons::Age Groups::Infant::Infant Newborn::Infant Low Birth Weight::Infant Small for Gestational Age [Medical Subject Headings]:Chemicals and Drugs::Inorganic Chemicals::Nitrogen Compounds::Nitrogen Oxides [Medical Subject Headings]Emisiones de VehículosFemalepregnancyEnvironmental MonitoringCohort studyAdultmedicine.medical_specialty:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]nitrogen dioxideEmbarazoBirth weightMonitoreo del AmbienteExposición por Inhalación:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size [Medical Subject Headings]:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]Young AdultRecién Nacido Pequeño para la Edad Gestacional:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]HumansPregnancybusiness.industryResearchBencenoInfant NewbornPublic Health Environmental and Occupational Healthbirth weightAnthropometrymedicine.disease:Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Residence Characteristics [Medical Subject Headings]Confidence interval:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons Cyclic::Hydrocarbons Aromatic::Benzene [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies [Medical Subject Headings]:Check Tags::Female [Medical Subject Headings]Spain:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings]Contaminantes del AireSmall for gestational ageEstudios de CohortesbusinessDemographyEnvironmental Health Perspectives
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