6533b7d9fe1ef96bd126d7b4

RESEARCH PRODUCT

Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain

Jordi SunyerEsther Gracia-lavedanMariana F FernandezLoreto Santa MarinaFernando GoñiFerran BallesterCristina M. VillanuevaSabrina LlopJesús IbarluceaManolis KogevinasXavier BasagañaCarmen FreireAdonina TardónJoan O. Grimalt

subject

PediatricsFetus -- CreixementBathingHealth Toxicology and MutagenesisEspaña:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Cohort Studies:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models Theoretical [Medical Subject Headings]small for gestational agePregnancynewbornFemeninosExposición a Riesgos Ambientales:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]water pollutionInfeccions respiratòries -- EpidemiologiaAdultodisinfection by-products:Named Groups::Persons::Age Groups::Infant::Infant Newborn::Infant Low Birth Weight [Medical Subject Headings]Modelos TeóricosEnvironmental exposurepremature birthNacimiento PrematuroHumanos:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Logistic Models [Medical Subject Headings]Premature birthInfant Small for Gestational AgeGestation:Named Groups::Persons::Age Groups::Infant::Infant Newborn::Infant Low Birth Weight::Infant Small for Gestational Age [Medical Subject Headings]Femaleepidemiologymedicine.symptomAigua -- DepuracióAdultmedicine.medical_specialtytrihalomethanesContaminantes Químicos del AguaEmbarazoBirth weight:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]Embaràs -- Aspectes nutricionalsRecién nacidoRecién Nacido Pequeño para la Edad GestacionalEnvironmental healthmedicine:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]cohort studyModelos LogísticosHumanslow birth weightEpidemiologiaRecién Nacido de Bajo Peso:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons Halogenated::Trihalomethanes [Medical Subject Headings]Pregnancybusiness.industryTrihalometanoResearchPublic Health Environmental and Occupational HealthInfant Newbornbirth weightEnvironmental ExposureInfant Low Birth WeightModels Theoreticalmedicine.diseaseLow birth weightLogistic Models:Check Tags::Female [Medical Subject Headings]Spain:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings]Small for gestational age:Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants::Water Pollutants::Water Pollutants Chemical [Medical Subject Headings]:Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Obstetric Labor Complications::Obstetric Labor Premature::Premature Birth [Medical Subject Headings]businessEstudios de CohortesWater Pollutants Chemical

description

Background: Evidence associating exposure to water disinfection by-products with reduced birth weight and altered duration of gestation remains inconclusive. Objective: We assessed exposure to trihalomethanes (THMs) during pregnancy through different water uses and evaluated the association with birth weight, small for gestational age (SGA), low birth weight (LBW), and preterm delivery. Methods: Mother–child cohorts set up in five Spanish areas during the years 2000–2008 contributed data on water ingestion, showering, bathing, and swimming in pools. We ascertained residential THM levels during pregnancy periods through ad hoc sampling campaigns (828 measurements) and regulatory data (264 measurements), which were modeled and combined with personal water use and uptake factors to estimate personal uptake. We defined outcomes following standard definitions and included 2,158 newborns in the analysis. Results: Median residential THM ranged from 5.9 μg/L (Valencia) to 114.7 μg/L (Sabadell), and speciation differed across areas. We estimated that 89% of residential chloroform and 96% of brominated THM uptakes were from showering/bathing. The estimated change of birth weight for a 10% increase in residential uptake was –0.45 g (95% confidence interval: –1.36, 0.45 g) for chloroform and 0.16 g (–1.38, 1.70 g) for brominated THMs. Overall, THMs were not associated with SGA, LBW, or preterm delivery. Conclusions: Despite the high THM levels in some areas and the extensive exposure assessment, results suggest that residential THM exposure during pregnancy driven by inhalation and dermal contact routes is not associated with birth weight, SGA, LBW, or preterm delivery in Spain.

yearjournalcountryeditionlanguage
2011-12-01
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