Search results for "Erich"

The Administration of Escherichia coli Nissle 1917 Ameliorates Development of DSS-Induced Colitis in Mice

2018

The beneficial effects of probiotics on immune-based pathologies such as inflammatory bowel disease (IBD) have been well reported. However, their exact mechanisms have not been fully elucidated. Few studies have focused on the impact of probiotics on the composition of the colonic microbiota. The aim of the present study was to correlate the intestinal anti-inflammatory activity of the probiotic Escherichia coli Nissle 1917 (EcN) in the dextran sodium sulfate (DSS) model of mouse colitis with the changes induced in colonic microbiota populations. EcN prevented the DSSinduced colonic damage, as evidenced by lower disease activity index (DAI) values and colonic weight/length ratio, when compa…

Reporting in Conflict Zones in Pakistan: Risks and Challenges for Fixers

2020

As a backbone of reporting in war and conflicts, fixers offer essential assistance to the foreign correspondent in conflict zones, also in Pakistan. With valuable local knowledge and contacts, fixers can arrange travel to secure entry of foreign correspondents into conflict zones in addition to securing interviews with otherwise unattainable figures, while offering reliable translation services. Pakistani media, despite being one of the largest and most developed in South Asia, remains under the strict control of powerful military establishment and government, while seeming to mirror the overarching government sentiment with a distinct lack of research-based news. Challenging this state of …

Landelinus, l’auteur de la plaque-boucle mérovingienne au Christ de l’Apocalypse découverte à Ladoix-Serrigny (Côte-d’Or) serait-il saint Landeli…

2021

Cette note concerne l’exceptionnelle plaque-boucle au Christ cavalier de l’Apocalypse découverte à Ladoix-Serrigny et étudiée précédemment dans cette revue. Son objectif est de discuter l’hypothèse récemment émise selon laquelle saint Landelin, qui a vécu au VIIe siècle dans le nord de la Gaule, serait Landelinus, l’auteur de cet objet. Plusieurs arguments militent en faveur de cette interprétation qui nous paraît donc plausible, même si elle reste fragile. Il est également envisagé de localiser cette fabrication dans le prestigieux monastère de Luxeuil. Mais il s’agit là encore d’une hypothèse. This note concerns the exceptional buckle-plate to the Christ cavalier of the Apocalypse discove…

Kritiikin lupaus : näkökulmia Frankfurtin koulun kriittiseen teoriaan

1998

Prophet of radicalism : Erich Fromm and the figurative constitution of the crisis of modernity

2010

Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli

2019

Tyrosine nitration is a post-translational protein modification relevant to various pathophysiological processes. Chemical nitration procedures have been used to generate and study nitrated proteins, but these methods regularly lead to modifications at other amino acid residues. A novel strategy employs a genetic code modification that allows incorporation of 3-nitrotyrosine (3-NT) during ribosomal protein synthesis to generate a recombinant protein with defined 3-NT-sites, in the absence of other post-translational modifications. This approach was applied to study the generation and stability of the 3-NT moiety in recombinant proteins produced in E.coli. Nitrated alpha-synuclein (ASYN) was…

Microencapsulation of Enteric Bacteriophages in a pH-Responsive Solid Oral Dosage Formulation Using a Scalable Membrane Emulsification Process

2019

A scalable low-shear membrane emulsification process was used to produce microencapsulated Escherichia coli-phages in a solid oral dosage form. Uniform pH-responsive composite microparticles (mean size ~100 &micro

Data from: Fight evolution with evolution: plasmid-dependent phages with a wide host range prevent the spread of antibiotic resistances

2013

The emergence of pathogenic bacteria resistant to multiple antibiotics is a serious worldwide public health concern. Whenever antibiotics are applied, the genes encoding for antibiotic resistance are selected for within bacterial populations. This has led to the prevalence of conjugative plasmids that carry resistance genes and can transfer themselves between diverse bacterial groups. In this study, we investigated whether it is feasible to attempt to prevent the spread of antibiotic resistances with a lytic bacteriophage, which can replicate in a wide range of gram-negative bacteria harboring conjugative drug-resistance conferring plasmids. The counter-selection against the plasmid was sho…

Cartilage Regeneration and Tissue Engineering

2019

Abstract Articular cartilage in synovial joints is a hyaline cartilage highly hydrated with a rigorous order of cells and fibers and a specific content of proteoglycans and glycoproteins. It provides a low-friction surface, participates in the lubrication of the synovial joints, and distributes the forces to the underlying bone. It is an avascular and aneural tissue where small metabolites diffuse to and from cells. Unlike hyaline cartilage in other locations, articular cartilage lacks perichondrium, a layer of fibrous tissue around it that serves as the source of new cartilage cells. Thus, although extracellular matrix undergoes continuous remodeling throughout life, the ability to repair …

In vivo evaluation of the interaction between the Escherichia coli IGP synthase subunits using the Bacterial Two-Hybrid system

2020

ABSTRACT Histidine biosynthesis is one of the most characterized metabolic routes for its antiquity and its central role in cellular metabolism; indeed, it represents a cross-road between nitrogen metabolism and de novo synthesis of purines. This interconnection is due to the activity of imidazole glycerol phosphate synthase, a heterodimeric enzyme constituted by the products of two his genes, hisH and hisF, encoding a glutamine amidotransferase and a cyclase, respectively. Despite their interaction was suggested by several in vitro experiments, their in vivo complex formation has not been demonstrated. On the contrary, the analysis of the entire Escherichia coli interactome performed using…