Search results for "Escape"
showing 10 items of 119 documents
A possible evolutionary model of “aligned pockmarks”
2014
Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours
2019
BACKGROUND: Interferon-induced expression of programmed cell death ligands (PD-L1/PD-L2) may sustain tumour immuneevasion. Patients featuring MET amplification, a genetic lesion driving transformation, may benefit from anti-MET treatment. We explored if MET-targeted therapy interferes with Interferon-gamma modulation of PD-L1/PD-L2 in MET-amplified tumours.METHODS: PD-L1/PD-L2 expression and signalling pathways downstream of MET or Interferon-gamma were analysed in MET-amplified tumour cell lines and in patient-derived tumour organoids, in basal condition, upon Interferon-gamma stimulation, and after anti-MET therapy.RESULTS: PD-L1 and PD-L2 were upregulated in MET-amplified tumour cells up…
Exciton recombination dynamics inInAs∕InPself-assembled quantum wires
2005
In this work we investigate the exciton recombination dynamics in InAs/ InP semiconductor self-assembled quantum wires, by means of continuous wave and time resolved photoluminescence. The continuous wave photoluminescence results seem to indicate that the temperature quenching of the emission band seems to be more probably due to unipolar thermal escape of electrons towards the InP barrier. On the other hand, the analysis of time resolved photoluminescence reveals that the temperature dependence of the radiative and nonradiative recombination times is mainly determined by the dynamics of excitons localized by disorder shigh energy tail of the PL bandd and strongly localized slow energy tai…
Large-scale glaciotectonically-deformed Pleistocene sediments with deformed layers sandwiched between undeformed layers, Baltmuiža site, Western Latv…
2018
Fluid escape structures in the Graham Bank region (Sicily Channel, Central Mediterranean) revealing volcanic and neotectonic activity
2016
In the Sicily Channel, (Central Mediterranean), two geodynamic processes overlap each other, the Maghrebides- Apennines accretionary prism and the Sicily Channel rift. Moreover, the northwestern sector (Banks sector) is characterised by an irregular seafloor morphology linked to the recent volcanic and tectonic activity.In order to discriminate the role exerted by both the processes in the morphostructural setting of the area we used a dataset of both high and very high resolution single-channel and multi-channel profiles, acquired in the frame of the RITMARE project respectively with CHIRP and sparker, and airgun sources, and high resolution (5 m cell) morpho-bathymetric data. The data all…
NEOTECTONIC ACTIVITY AND EMISSION OF FLUIDS IN THE NORTHWEST SICILY CHANNEL
The southern Sicilian coast represents an important contribution to Italian tourism, the Sicily Channel is an important communication path because at the top of its seafloor there are many pipelines, and submarine communication cables which are laid to carry signals, and which are very important to the minor islands. In this work, we are presenting results of the detailed geomorphological and seismostratigraphic analysis based on new very high-resolution dataset (multibeam and CHIRP) acquired during the ACUSCAL 2015 Cruise. We also used low resolution bathymetric and seismic data provided from online database (ViDEPI, GEBCO, EMODnet). This study allows us to reconstruct the tectonic volcani…
PROCESSI ATTIVI NEL MARGINE CONTINENTALE DELLA SICILIA NORD-OCCIDENTALE: NEOTETTONICA, RISALITA DI FLUIDI E FENOMENI GRAVITATIVI
2014
La ricerca riguarda l’analisi degli elementi morfostrutturali, le strutture legate alle emissioni di fluidi ed i fenomeni di trasporto sia gravitativo che selettivo, in ambiente sommerso ed emerso, presenti nel settore del margine continentale nord-siciliano compreso tra i meridiani passanti per le isole Egadi e Cefalù, al fine di ottenere un modello evolutivo durante il Quaternario. In particolare sono stati studiati in dettaglio: a) gli elementi morfostrutturali, al fine di ottenere informazioni sull’evoluzione recente dell’area, concentrando l’attenzione sulle faglie recenti e attive, integrando anche le informazioni concernenti la sismicità dell’area, ricavati dai database online; b) le…
Increased frequencies of CD11b+CD33+CD14+HLA-DRlowmyeloid-derived suppressor cells are an early event in melanoma patients
2014
Myeloid-derived suppressor cells (MDSC) are a heterogeneous cell population characterized by immunosuppressive activity. Elevated levels of MDSC in peripheral blood are found in inflammatory diseases as well as in malignant tumors where they are supposed to be major contributors to mechanisms of tumor-associated tolerance. We investigated the frequency and function of MDSC in peripheral blood of melanoma patients and observed an accumulation of CD11b(+) CD33(+) CD14(+) HLA-DR(low) MDSC in all stages of disease (I-IV), including early stage I patients. Disease progression and enhanced tumor burden did not result in a further increase in frequencies or change in phenotype of MDSC. By investig…
“Sensing” the destination: Development of the destination sensescape index
2021
Abstract Despite the increasing academic interest in the sensory dimension of the tourist experience, the quantitative empirical research in the field is limited by a lack of measurement instruments for evaluating the sensory stimuli perceived by tourists during a destination visit. The study addresses this gap by developing a composite index to assess the sensory destination panorama, termed as “destination sensescape”. The construct is conceptualised as a formative multidimensional variable with 5 dimensions (visualscape, smellscape, tastescape, soundscape, and hapticscape). The psychometric validity and reliability of the 17 items integrating the formative index were established by a rig…
Dendritic cells as a tool to induce anergic and regulatory T cells
2001
Abstract The induction of antigen-specific T-cell tolerance in the thymus and its maintenance in the periphery is crucial for the prevention of autoimmunity. As well as their stimulatory functions, there is growing evidence that dendritic cells, acting as professional antigen-presenting cells, also maintain and regulate T-cell tolerance in the periphery. This control function is exerted by certain maturation stages and subsets of different ontogeny, and can be influenced by immunomodulatory agents. What is the current state of knowledge of the ‘immunoregulatory' properties of dendritic cells and how might tolerance-inducing dendritic cells be relevant to therapeutic applications in humans?