Search results for "Estro."
showing 10 items of 770 documents
Potenza. Paesaggio e luce
2011
La tesi riguarda l’evoluzione del lavoro degli architetti che si è definitivamente svincolato dal determinismo modernista del progetto di architettura per approdare al relativismo critico del progetto di paesaggio. Il progetto è pensato prioritariamente in relazione a ciò che percepisce la comunità locale, e non al pensiero unico del progettista che determina una trasformazione secondo un principio insediativo astratto. Esiste una nuova modernità che si evolve secondo strategie proprie della cultura della nostra epoca. Ogni comunità esprime una cultura locale, che è connessa con la cultura universale. In questo momento la cultura universale esprime disordine, incertezze, una mescola di situ…
Advancing the ecotoxicological relevancy of zebrafish : application of early-juvenile 20dpfZF to assess xenoestrogenicity of environmental chemicals …
2014
Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor
2020
The intensive use of pesticides has led to their increasing presence in water, soil, and agricultural products. Mounting evidence indicates that some pesticides may be endocrine disrupting chemicals (EDCs), being therefore harmful for the human health and the environment. In this study, three pesticides, glyphosate, thiacloprid, and imidacloprid, were tested for their ability to interfere with estrogen biosynthesis and/or signaling, to evaluate their potential action as EDCs. Among the tested compounds, only glyphosate inhibited aromatase activity (up to 30%) via a non-competitive inhibition or a mixed inhibition mechanism depending on the concentration applied. Then, the ability of the thr…
Secuestro de carbono en arrozales costeros para la mitigación y adaptación al cambio climático. El delta del Ebro como caso de estudio
2022
La agricultura ha contribuido al cambio climático, y al mismo tiempo, dicho cambio afecta a la producción agrícola. Para resolver esta situación, la gestión agrícola debe adoptar medidas que aborden conjuntamente el reto de mitigación y adaptación al cambio climático para así reducir el impacto en el clima y garantizar la seguridad alimentaria. El cultivo del arroz es importante para la alimentación humana, pero su producción en las zonas costeras está amenazada por el aumento del nivel mar. Este cultivo tiene un gran potencial para secuestrar carbono, aunque la gestión agrícola habitual produce gran cantidad de gases de efecto invernadero (GEI), promoviendo el calentamiento global. Los mec…
Biodegradacja przemysłowych olejów estrowych metodą osadu czynnego
2013
Heterocyclisch anellierte Steroide aus 2-Hydroxymethylen-canrenon
1995
A-ring annulated heterocycles, the isoxazole 6, the pyrazoles 8 and the pyrimidines 9 are prepared starting from 2-hydroxymethylene canrenone 1. Binding studies were carried out with the compounds 1 and 6-8 using estrogen, progesterone, androgen, gluco- and mineralocorticoid receptors as well as the serum proteins SHBG and CBG: the substances were inactive on the receptor level. 1, 7 and 8a show weak binding affinity to CBG.
Comment on "Effects of Elastic Resistance Band Exercise on Postural Balance, Estrogen, Bone Metabolism Index, and Muscle Strength of Perimenopausal P…
2017
Use of Early Juvenile Zebrafish Danio Rerio for In-Vivo Assessment of Endocrine Modulation by Xenoestrogens
2013
Reliable and cost-effective early-life stage (ELS) bioassays incorporating practical experimentation without compromising scientific relevance are crucial in chemical risk assessment. This study investigated the use of 20 days- post-fertilization life stage ( 20dpfZF ) of zebrafish Danio rerio to screen environmental chemicals known to be estrogenic in adult fish. Firstly, studies with key genes in steroidogenesis were conducted; the brain isoform of aromatase gene ( cyp19a1b ) being the most prominently expressed biomarker. Regulation of mRNA levels of molecular biomarkers, vitellogenin 1 gene ( vtg1) and cyp19a1b were selected to assess the endocrine modulation by xenoestrogens, 17α-ethin…
High expression of progesterone receptor may be an adverse prognostic factor in oestrogen receptor-negative/progesterone receptor-positive breast can…
2021
Oestrogen receptor (ER)-negative (–) progesterone receptor (PgR)-positive (+) is the least common combination of steroid receptor expression observed in breast cancer. There are many controversies regarding the actual existence of ER–/PgR+ phenotype. In the current study, we aimed to perform comprehensive immunohistochemical re-evaluation of ER–/PgR+ breast cancers from multiple institutions. A total of 135 cases of ER–/PgR+ breast cancer were collected from 11 institutions from the period 2006–2020 and subsequently stained with three clinically validated anti-ER antibody clones: SP1 (Roche), 1D5 (Dako), and EP1 (Dako), and two anti-PgR antibody clones: 636 (Dako), and 1E2 (Roche). Clinicop…
Endometrial Adenocarcinoma in Syrian Hamsters Treated with Diethylstilbestrol, Tamoxifen and N-Ethyl-Nitrosourea
2006
The synthetic estrogen diethylstilbestrol (DES) causes marked abnormalities in the female hamster genital tract, after either prenatal or postnatal exposure, leading to endometrial hyperplasia and carcinoma. Acting as an initiating event, DES altering uterine development may facilitate the abnormal response of promoting agents. Tamoxifen (TAM) is an antiestrogen that competes for central and peripheral estrogen receptor (ERα). TAM exerts agonistic effects on E-dependent endometrial proliferation. N-ethyl-N-nitrosourea (ENU), a potent mutagenic agent, induces tumors in a variety of organs, predominantly in the peripheral nervous system. To test whether ENU and TAM treatment in a model of hyp…