6533b7cefe1ef96bd1256f0d
RESEARCH PRODUCT
Heterocyclisch anellierte Steroide aus 2-Hydroxymethylen-canrenon
Michael SchaffrathKunhard PollowKlaus GörlitzerPeter Moormannsubject
biologymedicine.drug_classStereochemistrymedicine.medical_treatmentPharmaceutical ScienceAndrogenSteroidchemistry.chemical_compoundSex hormone-binding globulinBiochemistrychemistryEstrogenMineralocorticoidDrug Discoverymedicinebiology.proteinCanrenoneIsoxazoleReceptorhormones hormone substitutes and hormone antagonistsmedicine.drugdescription
A-ring annulated heterocycles, the isoxazole 6, the pyrazoles 8 and the pyrimidines 9 are prepared starting from 2-hydroxymethylene canrenone 1. Binding studies were carried out with the compounds 1 and 6-8 using estrogen, progesterone, androgen, gluco- and mineralocorticoid receptors as well as the serum proteins SHBG and CBG: the substances were inactive on the receptor level. 1, 7 and 8a show weak binding affinity to CBG.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-01-01 | Archiv der Pharmazie |