Search results for "FAD"
showing 10 items of 292 documents
On the Statistical Analysis of Equal Gain Combining over Multiple Double Rice Fading Channels in Cooperative Networks
2010
This article analyzes the statistical properties of narrowband mobile-to-mobile (M2M) fading channels with equal gain combining (EGC) under line-of-sight (LOS) propagation conditions. Here, we study a dual-hop amplify-and-forward (AF)relay network. It is assumed that there can exist LOS components in the transmission links between the source mobile station and the destination mobile station via K mobile relays. In order to cater for asymmetric fading conditions in the relay links, the received signal envelope at the output of the equal gain (EG) combiner is thus modeled as a sum of K double Rice processes. These processes are considered to be independent but not necessarily identically dist…
Performance Enhancement of Multimedia Broadcast Multicast Service (MBMS) with Receive Diversity
2007
The aim of this paper is to evaluate the effect of receive diversity on multimedia broadcast multicast service (MBMS) performance in wideband code division multiple access (WCDMA) networks. In addition to time diversity provided by long interleaving and receive diversity provided by multiple receive antennas, 3GPP release 6 specifications for MBMS introduce two macro diversity schemes: soft and selective combining. Diversity techniques are introduced in order to improve the MBMS performance. Improvements help especially the cell edge MBMS users who suffer most from the fading channel conditions. As receive diversity is one of the most efficient diversity techniques this paper examines the s…
Level-Crossing Rate and Average Duration of Fades in Non-Isotropic Hoyt Fading Channels with Applications to Selection Combining Diversity
2015
In this paper, we investigate the second-order statistics of Hoyt fading channels under non isotropic scattering scenarios. Assuming an asymmetrical Doppler power spectral density (PSD), we derive, in the form of single finite-range integrals, expressions for the level-crossing rate (LCR) and average duration of fades (ADF). These new results are then applied to obtain the LCR and ADF of selection combining (SC) diversity over non-isotropic Hoyt channels. In addition to their importance for studying the system performance and characterizing the dynamic behavior of multipath fading channels, the formulas derived are general in that they can be applied to many non-isotropic scattering situati…
cFLIPL Inhibits Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated NF-κB Activation at the Death-inducing Signaling Complex in Human Ke…
2004
Human keratinocytes undergo apoptosis following treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via surface-expressed TRAIL receptors 1 and 2. In addition, TRAIL triggers nonapoptotic signaling pathways including activation of the transcription factor NF-kappaB, in particular when TRAIL-induced apoptosis is blocked. The intracellular protein cFLIP(L) interferes with TRAIL-induced apoptosis at the death-inducing signaling complex (DISC) in many cell types. To study the role of cFLIP(L) in TRAIL signaling, we established stable HaCaT keratinocyte cell lines expressing varying levels of cFLIP(L). Functional analysis revealed that relative cFLIP(L) levels correlat…
Ķermeņa masas indeksa ietekme uz paplašinātās limfadenektomijas kvalitāti kunģa vēža pacientiem
2017
Aktualitāte. Saslimstība ar kuņģa vēzi katru gadu pieaug. Arvien vairāk kuņģa vēzis tiek diagnosticēts novēlotās stadijās, kad pacienta dzīvildze un dzīves kvalitāte ir ievērojami samazināta. Mūsdienās pieaug arī aptaukošanās risks, kas ir viens no riska faktoriem kuņģa vēža attīstībai. Liela daļa pacienti pie ārsta ierodas jau ieilgušā stadija ar ievērojamu aptaukošanos, kas apgrūtina ķirurģisko ārstēšanu. Veicot radikālu operāciju, papildus noteikti ir jāveic limfadenektomija, lai uzlabotu ārstēšanas rezultātus un nepieļautu metastāžu veidošanos. Darba mērķis: izpētīt kā ķermeņa masas indekss ietekmē paplašinātās limfadenektomijas kvalitāti ( izdalīto limfmezglu skaits), pēcoperāciju komp…
El aprendizaje de los rasgos fonopragmáticos del enfado en español como lengua extranjera
2020
espanolIdentificar la expresion de enfado en una lengua extranjera y reproducirla con adecuacion y precision son destrezas cuya relevancia y falta de propuestas satisfactorias han sido senaladas por las investigaciones sobre la ensenanza de emociones (Dewaele, 2010; Toya & Kodis, 1996). Este trabajo combina la identificacion de carencias en la didactica de la entonacion emocional con el analisis de muestras espontaneas de enfado como base de unas pautas didacticas para introducir la ensenanza contextualizada de la expresion de enfado en espanol. A traves de muestras de un corpus coloquial, se identifican los rasgos caracteristicos de la expresion de enfado en espanol. Una seleccion de rasgo…
A Multi-Phase Decode-and-Forward Transmission Protocol in Cognitive Relay Networks: Outage Analysis and Relay Power Allocation
2015
Consider an underlay cognitive relay network with multiple source and destination pairs and that a decode-and-forward scheme is adopted at the relay. We propose a multi-phase transmission protocol in this paper which involves cooperation among source, relay and destination nodes. Given perfect interference elimination before decoding at the destination nodes, we derive closed-form expressions for outage probability calculation over Rayleigh fading channels. Furthermore, the optimal relay power allocation factor which leads to minimal outage probability is determined. Numerical results reveal the conditions under which satisfactory performance can be achieved based on the proposed scheme.
Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo
2010
Background & Aims Apoptosis is crucially involved in acute and chronic liver injury, including viral, cholestatic, toxic, and metabolic liver disease. Additionally, dysregulation of apoptosis signaling pathways has been implicated in hepatocarcinogenesis. The most prominent members of the apoptosis-mediating tumor necrosis factor receptor superfamily are the TNF-R1 (CD120a) and the CD95 (Apo-1/Fas) receptor. Although extensively studied, the intracellular signaling events in hepatocytes are only incompletely understood. Methods To examine the role of the caspase-8 homolog cellular FLICE-inhibitory protein (c-FLIP) in liver injury, we generated mice with hepatocyte specific deletion of c-FLI…
Dominant negative MORT1/FADD rescues mice from CD95 and TNF-induced liver failure
2002
Derangement of the apoptotic program is considered an important cause of liver disease. It became clear that receptor-mediated apoptosis is of specific interest in this context, and CD95 and CD120a, both members of the tumor necrosis factor (TNF) receptor superfamily, are the most prominent cell death receptors involved. The death signal is induced upon ligand binding by recruitment of caspases via the adapter molecule MORT1/FADD to the receptor and their subsequent activation. To investigate the role of MORT1/FADD in hepatocyte apoptosis, we generated transgenic mice expressing liver-specific dominant negative mutant. Mice looked grossly normal; breeding and liver development were not diff…
Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.
2012
Chronic liver disease promotes hepatocellular injury involving apoptosis and triggers compensatory regeneration that leads to the activation of quiescent stellate cells in the liver. The deposition of extracellular matrix from activated myofibroblasts promotes hepatic fibrosis and the progression to cirrhosis with deleterious effects on liver physiology. The role of apoptosis signaling pathways in the development of fibrosis remains undefined. The aim of the current study was to determine the involvement of the caspase-8 homologue cellular FLICE-inhibitory protein (cFLIP) during the initiation and progression of fibrosis. Liver injury and fibrosis from carbon tetrachloride (CCl4) and thioa…