Search results for "FAILURE"
showing 10 items of 1977 documents
Results of heart retransplantation: subanalysis of the Spanish Heart Transplant Registry
2021
Heart retransplantation (ReHT) is controversial in the current era. The aim of this study was to describe and analyze the results of ReHT in Spain. Methods We performed a retrospective cohort analysis from the Spanish Heart Transplant Registry from 1984 to 2018. Data were collected on donors, recipients, surgical procedure characteristics, immunosuppression, and survival. The main outcome was posttransplant all-cause mortality or need for ReHT. We studied differences in survival according to indication for ReHT, the time interval between transplants and era of ReHT. Results A total of 7592 heart transplants (HT) and 173 (2.3%) ReHT were studied (median age, 52.0 and 55.0 years, respectively…
Graph-grammar semantics of a higher-order programming language for distributed systems
1994
We will consider a new tiny, yet powerful, programming language for distributed systems, called DHOP, which has its operational semantics given as algebraic graph rewrite rules in a certain category of labeled graphs. Our approach allows to separate actions which affect several processes from local changes such as variable bindings. We also sketch how to derive an implementation from this specification.
Bayesian Survival Analysis to Model Plant Resistance and Tolerance to Virus Diseases
2017
Viruses constitute a major threat to large-scale production of crops worldwide producing important economical losses and undermining sustainability. We evaluated a new plant variety for resistance and tolerance to a specific virus through a comparison with other well-known varieties. The study is based on two independent Bayesian accelerated failure time models which assess resistance and tolerance survival times. Information concerning plant genotype and virus biotype were considered as baseline covariates and error terms were assumed to follow a modified standard Gumbel distribution. Frequentist approach to these models was also considered in order to compare the results of the study from…
Akutes Lungenversagen bei Malaria tropica in der Schwangerschaft: Erfolgreiche Behandlung durch extrakorporale CO2-Elimination
2008
Eine 32jahrige Schwangere (26. Schwangerschaftswoche) erkrankte am 6. Tag nach der Ruckkehr von einem Indonesienaufenthalt mit Fieber bis 42°C, hamolytischer Anamie (Hamoglobin 7,6 g/dl) und Thrombozytopenie (7000/µl). Es wurde eine Malaria diagnostiziert; eine Prophylaxe hatte sie nicht durchgefuhrt. Unter antiparasitarer Chemotherapie mit Chloroquin, Chinin und Pyrimethamin kam es zur Elimination der Parasiten (Makrogametozyten von Plasmodium falciparum) aus dem peripheren Blut. Im weiteren Verlauf entwickelte sich jedoch ein progredientes Lungenversagen und eine therapierefraktare Pneumonie, die zu einem »adult respiratory distress syndrome« (ARDS; Morel-Stadium 4) fuhrten. Bei drohendem…
Implicaciones pronósticas de la hipo e hiperpotasemia en la insuficiencia cardíaca aguda con fracción de eyección reducida. Análisis de la mortalidad…
2022
Resumen Antecedentes y objetivos Las alteraciones del potasio constituyen un problema clinico de gran magnitud en la insuficiencia cardiaca (IC) descompensada. Este estudio pretende valorar las implicaciones pronosticas de la hipo e hiperpotasemia al ingreso por IC aguda en la mortalidad cardiovascular y reingresos hospitalarios. Material y metodo De enero de 2016 a junio de 2020 fueron ingresados 1.397 casos con diagnostico de IC aguda. Se excluyeron ingresos programados para estudio, terapias electivas y pacientes con fraccion de eyeccion del ventriculo izquierdo > 40%. El estudio se realizo sobre 689 pacientes, 45 con potasio (K+) 5,0 mmol/l y 595 K+ = 3,5-5,0 mmol/l. Se analizaron…
Consommation alimentaire et durée d’hémodialyse chez l’insuffisant rénal chronique : corrélation aux paramètres nutritionnels
2004
Resume Le but de cette etude est de decrire la consommation alimentaire de patients atteints d’IRC apres differentes durees d’hemodialyse et d’etablir des correlations avec les parametres nutritionnels. 58 patients repartis en 3 groupes : GI :
Retreatment with interferon plus ribavirin of chronic hepatitis C non-responders to interferon monotherapy: a meta-analysis of individual patient dat…
2002
Background and aims: Retreatment with a combination of α interferon (IFN) plus ribavirin of patients with chronic hepatitis C who did not respond to IFN monotherapy has not been assessed in large controlled studies. Methods: To assess the effectiveness and tolerability of IFN/ribavirin retreatment of non-responders to IFN and to identify predictors of complete (biochemical and virological) sustained response, we performed a meta-analysis of individual data on 581 patients from 10 centres. Retreatment with various IFN schedules (mean total dose 544 mega units) and a fixed ribavirin dose (1000–1200 mg/daily depending on body weight) was given for 24–60 (mean 39.5) weeks. Results: Biochemical …
Dosimetric perturbations of a lead shield for surface and interstitial high-dose-rate brachytherapy.
2014
In surface and interstitial high-dose-rate brachytherapy with either (60)Co, (192)Ir, or (169)Yb sources, some radiosensitive organs near the surface may be exposed to high absorbed doses. This may be reduced by covering the implants with a lead shield on the body surface, which results in dosimetric perturbations. Monte Carlo simulations in Geant4 were performed for the three radionuclides placed at a single dwell position. Four different shield thicknesses (0, 3, 6, and 10 mm) and three different source depths (0, 5, and 10 mm) in water were considered, with the lead shield placed at the phantom surface. Backscatter dose enhancement and transmission data were obtained for the lead shields…
Risk assessment of component failure modes and human errors using a new FMECA approach: application in the safety analysis of HDR brachytherapy
2014
Failure mode, effects and criticality analysis (FMECA) is a safety technique extensively used in many different industrial fields to identify and prevent potential failures. In the application of traditional FMECA, the risk priority number (RPN) is determined to rank the failure modes; however, the method has been criticised for having several weaknesses. Moreover, it is unable to adequately deal with human errors or negligence. In this paper, a new versatile fuzzy rule-based assessment model is proposed to evaluate the RPN index to rank both component failure and human error. The proposed methodology is applied to potential radiological over-exposure of patients during high-dose-rate brach…
Prevalence and 30-Day Mortality in Hospitalized Patients With Covid-19 and Prior Lung Diseases.
2021
Patients with pre-existing respiratory diseases in the setting of COVID-19 may have a greater risk of severe complications and even death.A retrospective, multicenter, cohort study with 5847 COVID-19 patients admitted to hospitals. Patients were separated in two groups, with/without previous lung disease. Evaluation of factors associated with survival and secondary composite end-point such as ICU admission and respiratory support, were explored.1,271 patients (22%) had a previous lung disease, mostly COPD. All-cause mortality occurred in 376 patients with lung disease (29.5%) and in 819 patients without (17.9%) (Previous lung disease is a risk factor for mortality in patients with COVID-19.…