Search results for "FM"

On the thermo-mechanical behaviour of the IFMIF target assembly under steady state and transient operative scenarios

Analysis of the thermo-mechanical behaviour of IFMIF target assembly integrated with its support framework

2014

On the computational assessment of the IFMIF-EVEDA Target Assembly thermal behaviour

2011

Universidad Politécnica Radiotelevisión. Creación y primera etapa (2000-2008)

2012

En el artículo se trata la historia de los canales UPVRadio y Universidad Politécnica Televisión desde el año 2000 a 2008, incluyendo el proceso de estudio, diseño y puesta en marcha de ambos y una descripción de los objetivos, el modelo de gestión, la plantilla, los canales de emisión, la programación, la audiencia y las fuentes de financiación alternativa en el régimen permanente. Se comenta también la infraestructura de soporte de ambos canales, con apartados para las dependencias de la cadena, el equipamiento de la radio y el de la televisión. The article narrates the story of UPVRadio and Universidad Politecnica Television University from 2000 to 2008, including the process of study, d…

Economic and environmental sustainability of an AnMBR treating urban wastewater and organic fraction of municipal solid waste

2016

[EN] The objective of this study was to evaluate the economic and environmental sustainability of a sub- merged anaerobic membrane bioreactor (AnMBR) treating urban wastewater (UWW) and organic fraction of municipal solid waste (OFMSW) at ambient temperature in mild/hot climates. To this aim, power requirements, energy recovery from methane (biogas methane and methane dissolved in the effluent), consumption of reagents for membrane cleaning, and sludge handling (polyelectrolyte and energy consumption) and disposal (farmland, landfilling and incineration) were evaluated within different operating scenarios. Results showed that, for the operating conditions considered in this study, AnMBR tec…

Integrated prototyping and rendering system for the display of ceramic finds

2017

The project, carried out in collaboration between the Department of Architecture of Palermo and the Archaeological Museum Antonino Salinas of Palermo, proposes a system of integration and reconstruction of ceramic artefacts, using modeling, 3D printing and rendering processes for an integrated museum exhibition system, which the viewers can observe the fragment nearing the re-reconstructed fragment that reconstructs the original morphology and an interactive digital model in which the viewers can also observe the metric aspect and, where present, the decorative apparatus.

AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations

2005

Activating mutations of Flt3 are found in approximately one third of patients with acute myeloid leukemia (AML) and are an attractive drug target. Two classes of Flt3 mutations occur: internal tandem duplications (ITDs) in the juxtamembrane and point mutations in the tyrosine kinase domain (TKD). We and others have shown that Flt3-ITD induced aberrant signaling including strong activation of signal transducer and activator of transcription 5 (STAT5) and repression of CCAAT/estradiol-binding protein α (c/EBPα) and Pu.1. Here, we compared the signaling properties of Flt3-ITD versus Flt3-TKD in myeloid progenitor cells. We demonstrate that Flt3-TKD mutations induced autonomous growth of 32D ce…

Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain.

2005

Activating mutations in the FLT3 tyrosine kinase (TK) occur in approximately 35% of patients with acute myeloid leukemia (AML). Therefore, targeting mutated FLT3 is an attractive therapeutic strategy, and early clinical trials testing FLT3 TK inhibitors (TKI) showed measurable clinical responses. Most of these responses were transient; however, in a subset of patients blast recurrence was preceded by an interval of prolonged remission. The etiology of clinical resistance to FLT3-TKI in AML is unclear but is of major significance for the development of future therapeutic strategies. We searched for mechanisms of resistance in 6 patients with AML who had relapses upon PKC412 treatment. In an …

Self-Organization Pathways and Spatial Heterogeneity in Insulin Amyloid Fibril Formation

2009

At high temperature and low pH, the protein hormone insulin is highly prone to form amyloid fibrils, and for this reason it is widely used as a model system to study fibril formation mechanisms. In this work, we focused on insulin aggregation mechanisms occurring in HCl solutions (pH 1.6) at 60 degrees C. By means of in situ Thioflavin T (ThT) staining, the kinetics profiles were characterized as a function of the protein concentration, and two concurrent aggregation pathways were pointed out, being concentration dependent. In correspondence to these pathways, different morphologies of self-assembled protein molecules were detected by atomic force microscopy images also evidencing the prese…

Multi-subject fMRI analysis via combined independent component analysis and shift-invariant canonical polyadic decomposition

2014

Canonical polyadic decomposition (CPD) may face a local optimal problem when analyzing multi-subject fMRI data with inter-subject variability. Beckmann and Smith proposed a tensor PICA approach that incorporated an independence constraint to the spatial modality by combining CPD with ICA, and alleviated the problem of inter-subject spatial map (SM) variability.This study extends tensor PICA to incorporate additional inter-subject time course (TC) variability and to connect CPD and ICA in a new way. Assuming multiple subjects share common TCs but with different time delays, we accommodate subject-dependent TC delays into the CP model based on the idea of shift-invariant CP (SCP). We use ICA …