Search results for "FUNCTIONAL"
showing 10 items of 4822 documents
Theresa May’s Representation of Reality in her Brexit Speeches
2020
This study analyses Theresa May’s three seminal Brexit speeches. These describe the kind of desirable post-Brexit EU-UK relationship that she envisioned, and together constitute a corpus of 18,532 words. The speeches can be considered as landmarks on a timeline that was initially meant to lead to the delivery of Brexit. It is hypothesized that there may be meaningful differences between the speeches, and that these affect the representation of reality. These in turn would have a bearing on May’s discursive self-representation as either an individualized or a collectivized social actor. To account for such representational values, the study draws on Halliday’s Transitivity System (1994), sta…
Challenging the Victorian Nuclear Family Myth: The Incest Trope in Guillermo del Toro’s Crimson Peak
2020
espanolLa literatura (neo)victoriana ofrece conceptualizaciones contradictorias de la familia nuclear, ya que generalmente gira en torno a hogares tradicionales heteroparentales pero los presenta como fragmentados y profundamente disfuncionales. La pelicula Crimson Peak (2015) del director Guillermo del Toro se basa en tres motivos recurrentes en la ficcion gotica (neo) victoriana, los traumas domesticos, la familia disfuncional y lo sobrenatural. Mi objetivo principal es explorar como Del Toro utiliza la trama del incesto para subvertir las visiones preconcebidas e idealizadas sobre la familia victoriana. En primer lugar, analizo la casa ancestral y la figura materna como origen de los tra…
Functional bread supplemented with Pleurotus eryngii powder: A potential new food for human health
2022
The purpose of this study was to develop functional breads with powdered Pleurotus eryngii. The breads were produced applying the traditional Italian style sourdough technology. P. eryngii powder was added to flour of tender wheat varieties (Grano Dei Miracoli, Inalettabile, Mentana, Gentilrosso, Ardito and a mix of Rieti, Verna, and Mentana) or semolina of durum wheat landrace (Saragolla) and subjected to sourdough fermentation. Sourdough inoculum was produced with selected strains of lactic acid bacteria (LAB) belonging to the species Levilactobacillus brevis, Weissella cibaria and Leuconostoc citreum. The addition of Pleurotus powdered (PP) (10% w/w) did not influence the fermentation pr…
The importance of terracing in the traditional cultural landscapes: the case study of Sicily (Italy)
2012
The landscapes formed by agricultural terraces are the natural result of the encounter between the characteristics of an environment and the creative force and genius of man, the slow evolution of this relationship between nature and culture, a collective project that balanced the need for producing with the resources available and the native character of the environment. These cultural processes produced a great variety of landscapes. However, they are not supported or confirmed by common inventories allowing to identify and classify the typical Main Traditional Landscape (MTL) within which very important is the role carried out by terraces and related man-made structures, both for natural…
Test system for trifunctional antibodies in 3D MCTS culture.
2009
The aim of the present study was to assess the feasibility of a 3D tumor cell culture model, that is, multicellular tumor spheroids (MCTSs) as an adequate model for micrometastases and therefore as a pharmacological model for efficacy testing of trifunctional therapeutic antibodies. Unlike conventional monolayer cultures, spheroids allow researchers to study parameters, such as 3D cell shape, 3D cell arrangement and microenvironment, and penetration efficiency of defense cells that may largely influence the efficacy of antibody treatment in vivo. The authors established a long-term coculture of human MCTSs with peripheral blood mononuclear cells (PBMCs) to test the anticancer effect of the …
Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions
2022
Turmeric is a plant with a very long history of medicinal use across different cultures. Curcumin is the active part of turmeric, which has exhibited various beneficial physiological and pharmacological effects. This review aims to critically appraise the corpus of literature associated with the above pharmacological properties of curcumin, with a specific focus on antioxidant, anti-inflammatory, anticancer and antimicrobial properties. We have also reviewed the different extraction strategies currently in practice, highlighting the strengths and drawbacks of each technique. Further, our review also summarizes the clinical trials that have been conducted with curcumin, which will allow the …
Gallium-68 and scandium-44 labelled radiotracers based on curcumin structure linked to bifunctional chelators: Synthesis and characterization of pote…
2019
Abstract Curcumin metal complexes showed widespread applications in medicine and can be exploited as a lead structure for developing new tracers for nuclear medicine application. Herein, the synthesis, chemical characterization and radiolabelling with gallium-68 and scandium-44 of two new targeting vectors based on curcumin scaffolds and linked to the chelators 1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid (NODAGA) and 1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine (AAZTA) are reported. Synthesis of the precursors could be achieved with a 13% and 11% yield and radiolabelling generally afforded rapid incorporation under mild conditions (>95%). Sta…
Amplitude analysis ofB+→J/ψϕK+decays
2017
The first full amplitude analysis of B+→J/ψϕK+ with J/ψ→μ+μ−, ϕ→K+K− decays is performed with a data sample of 3 fb−1 of pp collision data collected at s√=7 and 8 TeV with the LHCb detector. The data cannot be described by a model that contains only excited kaon states decaying into ϕK+, and four J/ψϕ structures are observed, each with significance over 5 standard deviations. The quantum numbers of these structures are determined with significance of at least 4 standard deviations. The lightest is best described as a D±sD∗∓s cusp, but a resonant interpretation is also possible with mass consistent with, but width much larger than, previous measurements of the claimed X(4140) state. The mode…
Reinforced cyclam derivatives functionalized on the bridging unit
2016
International audience; A new synthetic method has been developed for the preparation of reinforced cyclams (1,4,8,11-tetraazacyclotetradecane) C-functionalized on the bridging unit, by using a "one pot" reaction starting from the appropriate bis-aminal cyclam intermediate. The high reactivity of quaternized aminal moiety toward nucleophilic agent has been used to elaborate a new class of cross-bridged and side-bridged cyclam derivatives containing cyanide group on the ethylene bridge. Several chelators and corresponding copper(II) complexes have been prepared and characterized by X-ray diffraction. These new constrained polyazamacrocycles are valuable precursors of bifunctional chelating a…
Photoinduced HS state in the first spin-crossover chain containing a cyanocarbanion as bridging ligand
2009
A new polymeric approach, based on cyanocarbanion ligands, for the design of spin crossover (SCO) compounds led us to the compound [Fe(abpt)2(tcpd)] (1) (tcpd^2 = (C[C(CN)2|3)^2 , abpt = 4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole) which has been characterised as the first SCO molecular chain involving a cyanocarbanion as bridging ligand. Gomez Garcia, Carlos Jose, Carlos.Gomez@uv.es