Search results for "Farm"
showing 10 items of 3554 documents
Natural products for the treatment of Type 2 Diabetes Mellitus
2015
Type 2 diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. High blood sugar can produce long-term complications such as cardiovascular and renal disorders, retinopathy, and poor blood flow. Its development can be prevented or delayed in people with impaired glucose tolerance by implementing lifestyle changes or the use of therapeutic agents. Some of these drugs have been obtained from plants or have a microbial origin, such as galegine isolated from Galega officinalis, which has a great similarity to the antidiabetic drug metformin. Picnogenol, acarbose, miglitol, and voglibose are other antidiabetic products of natural origin. This review compiles the princi…
Documento de consenso de la Sociedad Española de Arteriosclerosis (SEA) para la prevención y tratamiento de la enfermedad cardiovascular en la diabet…
2018
Este artículo se encuentra disponible en la siguiente URL: https://www.elsevier.es/es-revista-clinica-e-investigacion-arteriosclerosis-15-articulo-documento-consenso-sociedad-espanola-arteriosclerosis-S0214916818300846 This is the pre-peer reviewed version of the following article: Ruiz-García, A., Arranz-Martínez, E., Morón-Merchante, I., Pascual-Fuster, V., Tamarit, JJ., Trias-Villagut, F. et al. (2018). Documento de consenso de la Sociedad Española de Arteriosclerosis (SEA) para la prevención y tratamiento de la enfermedad cardiovascular en la diabetes mellitus tipo 2. Clínica e Investigación en Arteriosclerosis, vol. 30, supl. 1 (julio), pp. 1-19, which has been published in final form …
Chemical Composition of the Essential Oils of Three Species of the Apiaceae Family Growing Wild in Sicily: Bonannia graeca, Eryngium maritimum and Op…
2013
n the present study the chemical composition of the essential oils from aerial parts of Bonannia graeca (L.) Halácsy and Opopanax chironium (L.) Kock, and from aerial parts and roots of Eryngium maritimum L. was evaluated by GC and GC-MS. α-Pinene (15.2%) and β-pinene were recognized as the main constituents of B. graeca, whereas the aerial parts of O. chironium contained mainly the diterpene cembrene and the coumarin angelicin. In both aerial parts and roots of E. maritimum germacrene D (10.4% and 15.9%, respectively) and 2,4,5-trimethylbenzaldehyde (8.3% and 6.7%) were the most abundant components
Cathepsin L in metastatic bone disease: therapeutic implications
2010
AbstractCathepsin L is a lysosomal cysteine proteinase primarily devoted to the metabolic turnover of intracellular proteins. However, accumulating evidence suggests that this endopeptidase might also be implicated in the regulation of other important biological functions, including bone resorption in normal and pathological conditions. These findings support the concept that cathepsin L, in concert with other proteolytic enzymes involved in bone remodeling processes, could contribute to facilitate bone metastasis formation. In support of this hypothesis, recent studies indicate that cathepsin L can foster this process by triggering multiple mechanisms which, in part, differ from those of t…
A Curcumin-BODIPY Dyad and Its Silica Hybrid as NIR Bioimaging Probes
2022
In this paper we describe the synthesis of a novel bichromophoric system in which an efficient photoinduced intercomponent energy transfer process is active. The dyad consists of one subunit of curcumin and one of BODIPY and is able to emit in the far-red region, offering a large Stokes shift, capable of limiting light scattering processes for applications in microscopy. The system has been encapsulated in MCM-41 nanoparticles with dimensions between 50 and 80 nm. Both the molecular dyad and individual subunits were tested with different cell lines to study their effective applicability in bioimaging. MCM-41 nanoparticles showed no reduction in cell viability, indicating their biocompatibil…
Le piante medicinali nell'Acis Hortus Regius del farmacista Giuseppe Riggio (1758-1830)
2009
Pedacio Dioscorides Anazarbeo, annotado por el Doctor Andres Laguna ... : nuevamente ilustrado, y añadido, demonstrando las figuras de plantas, y ani…
Sig.: [calderó]-[7calderons]2, A-Gg4, A-Ee4 Tomo primero. - Que contiene el primero, y segundo libro de la Colectanea de la materia de los Medicamentos. - [28], 240, 224 p., [3], XXVI f. de làm Els grav. calc. - Els f. de làm. sense numerar signats per Joannes Perez, incloent escut heràldic de Felip V, a qui es dedica el vol., i retrat de Francisco Suárez de Ribera. - Capitals grav., vinyetes i altres ornaments tip Cada llibre amb pag. pròpia. - Port. a dues tintes amb grav. - Postil·les marginals als Preliminars. - Text a dues col. - Reclams
Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer
2009
We examine the possible evidence that the phytochemical curcumin may overcome resistance to hormonal and cytotoxic agents in breast cancer. We present our observations on MCF-7R, a multidrug-resistant (MDR) variant of the MCF-7 breast cancer cell line. In contrast to MCF-7, MCF-7R lacks aromatase and estrogen receptor alpha (ERalpha) and overexpresses the multidrug transporter ABCB1 and the products of different genes implicated in cell proliferation and survival, like c-IAP-1, NAIP, survivin, and COX-2. Nevertheless, in cytotoxicity and cell death induction assays, we found that the antitumor activity of curcumin is substantial both in MCF-7 and in MCF-7R. We elaborated the diketone system…
Les modes d'habitat à l'âge du Bronze en France
2018
The many discoveries made in preventive archaeology have drawn the picture of a highly anthropogenic landscape in Bronze Age France. Timber post buildings are the most common type of dwellings however other types of construction (sills, mudbrick, …) that have lighter foundations and are more susceptible to erosion are considered less common due to the inherent problems of identification. Small dwellings from 25 to 40 m2 with a quadrangular 1 to 3 aisled plan and built to house a nuclear family are the most common,. Other types of buildings differ from this standardised plan such as the long rectangular dwellings in Alsace dating to the Early Bronze Age (type Eching) or the Early Bronze Age …
Medikamentu bīstamo un potenciāli bīstamo palīgvielu izvērtējums VSIA "Bērnu klīniskā universitātes slimnīca" Neonatoloģijas klīnikā 2019. gadā
2021
Problēma: Ne visas palīgvielas no bioloģiskā viedokļa ir inertas, un dažiem pacientiem (īpaši jaundzimušajiem) var izraisīt palīgvielu blaknes. Pētījuma mērķis: Izpētīt VSIA “Bērnu klīniskā universitātes slimnīca” Neonatoloģijas klīnikā lietoto rūpnieciski ražoto medikamentu drošību jaundzimušajiem no palīgvielu viedokļa. Metode: No slimnīcas medikamentu uzskaites programmatūras tika iegūti dati par Neonatoloģijas klīnikā lietotiem medikamentiem. Izmantojot zāļu aprakstus, tika noskaidrotas katra medikamenta palīgvielas. Papildus tika izvērtētas potenciāli bīstamo medikamentu aizstāšanas iespējas. Rezultāti: No iepirktajiem medikamentiem 133 (57,3%) saturēja vismaz vienu nevēlamo palīgvielu…