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RESEARCH PRODUCT
A Curcumin-BODIPY Dyad and Its Silica Hybrid as NIR Bioimaging Probes
Chiara Maria Antonietta GangemiTania Maria Grazia SalernoAnna BarattucciFabio CucinottaPaola BonaccorsiGiovanna CalabresePaola PomaMaria Giovanna RizzoSebastiano CampagnaFausto Puntorierosubject
Boron CompoundsNIR probeOrganic Chemistryluminescence curcumin BODIPY NIR probes bioimaging bichromophoric dyadGeneral MedicineSettore CHIM/06 - Chimica OrganicaSilicon DioxideCatalysisComputer Science ApplicationsInorganic ChemistryBODIPYNIR probesluminescencebichromophoric dyadSettore BIO/14 - FarmacologiaNanoparticlescurcuminluminescence; curcumin; BODIPY; NIR probes; bioimaging; bichromophoric dyadPhysical and Theoretical ChemistrybioimagingMolecular BiologySpectroscopydescription
In this paper we describe the synthesis of a novel bichromophoric system in which an efficient photoinduced intercomponent energy transfer process is active. The dyad consists of one subunit of curcumin and one of BODIPY and is able to emit in the far-red region, offering a large Stokes shift, capable of limiting light scattering processes for applications in microscopy. The system has been encapsulated in MCM-41 nanoparticles with dimensions between 50 and 80 nm. Both the molecular dyad and individual subunits were tested with different cell lines to study their effective applicability in bioimaging. MCM-41 nanoparticles showed no reduction in cell viability, indicating their biocompatibility and bio-inertness and making them capable of delivering organic molecules even in aqueous-based formulations, avoiding the toxicity of organic solvents. Encapsulation in the porous silica structure directed the location of the bichromophoric system within cytoplasm, while the dyad alone stains the nucleus of the hFOB cell line.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-08-23 |