Search results for "FeNO"
showing 10 items of 1088 documents
Expert opinion on the metabolic complications of mTOR inhibitors
2018
Abstract Using mTOR inhibitors (mTORi) as anticancer drugs led to hyperglycemia (12–50%) and hyperlipidemia (7–73%) in phase-III trials. These high rates require adapted treatment in cancer patients. Before initiating mTORi treatment, lipid profile screening should be systematic, with fasting glucose assay in non-diabetic patients and HbA1C in diabetic patients. After initiation, lipid profile monitoring should be systematic, with fasting glucose assay in non-diabetic patients, every 2 weeks for the first month and then monthly. The HbA1C target is ≤ 8%, before and after treatment initiation in known diabetic patients and in case of onset of diabetes under mTORi. LDL-cholesterol targets sho…
Lack of Correlation of Plasma HDL With Fecal Cholesterol and Plasma Cholesterol Efflux Capacity Suggests Importance of HDL Functionality in Attenuati…
2018
A number of clinical findings suggested HDL-raising as a plausible approach to treat residual risk of CVD. However, lack of CVD risk reduction by elevated HDL cholesterol (HDL-C) through cholesterol ester transfer protein (CETP) inhibition and enhanced risk reduction in apolipoprotein A-I Milano (apoAI-M) individuals with low HDL-C shifted the focus from HDL-C level to HDL function. In the present study, we investigated correlations between HDL-C, HDL function, fecal cholesterol excretion, and ex vivo plasma cholesterol efflux capacity (CEC) in animal models using two HDL modulators, LXR and PPAR-α agonists. In C57Bl mice, LXR agonist, T1317, raised HDL-C by 30%, while PPAR-α agonist, fenof…
Urinary Bladder Weight and Function in a Rat Model of Mild Hyperglycemia and Its Treatment With Dapagliflozin
2019
Hypertrophy and dysfunction of the urinary bladder are consistently observed in animal models of type 1 and less consistently in those of type 2 diabetes. We have tested the effects of mild hyperglycemia (n = 10 per group) in a randomized, blinded study and, in a blinded pilot study, of type 2 diabetes (n = 6 per group) and its treatment with dapagliflozin (1 mg/kg per day) on weight, contraction, and relaxation of the rat bladder. Based on a combination of high-fat diet and a low dose of streptozotocin, animals in the main study reached a mean peak blood glucose level of about 300 mg/dl, which declined to 205 mg/dl at study end. This was associated with a small, if any, increase in bladder…
‘I just want someone to rub some life into them!’ : the lived experience of impaired sensation in the feet related to multiple sclerosis
2021
Background: Impaired sensation in the feet is a commonly reported symptom experienced by people with multiple sclerosis. Aim: To explore the lived experiences of people living with multiple sclerosis-related impaired sensation in their feet. Method: Five open, unstructured interviews were analysed using a descriptive phenomenological method developed by Amedeo Giorgi. Findings: The essential structure of the research phenomenon consists of six key constituents: sense of heightened awareness of body sensation; sense of changed relationship to the feet; sense of changed participation in daily life; sense of the self with multiple sclerosis; sense of the meaning of interaction with others; and…
Graduating Physiotherapy Students’ Conceptions of their own Competence
2017
A competence-oriented approach has recently emerged in higher education and thus far, not much attention has been paid to how “competence” itself is understood in education. The purpose of this study was to examine how graduating physiotherapy students perceive their competence at the end of their studies. The data comprised interviews with 33 graduating physiotherapy students. The data were analysed with the phenomenographic approach. The findings indicated that graduating students had different and wide-ranging conceptions of what competence in physiotherapy entails and what their own competence covers. The descriptive categories – mastering core skills, understanding the theoretical basi…
Patients’ conceptions of preoperative physiotherapy education before hip arthroplasty
2015
In Finland, over 7500 hip arthroplasties are performed annually. While the mean age of the patients has increased, the length of hospital stay has decreased, and this presents challenges for patient education. The aim of this study was to explore patients’ conceptions of preoperative physiotherapy education. This qualitative study included 10 hip arthroplasty patients. Data were collected using individual interviews at home before collecting preoperative information, and at the hospital after the operation. The interviews were tape-recorded and analysed using the phenomenographic method. Four hierarchically constructed categories of preoperative physiotherapy education were identified: read…
Physiotherapists’ conceptions of movement awareness– A phenomenographic study
2021
The phenomenon of movement awareness requires more attention to make it explicit in physiotherapy. The aim of this study was to explore the variation in physiotherapists’ conceptions of movement quality, focusing on movement awareness. The informants were 15 physiotherapists from a variety of physiotherapy fields. We collected data through two group interviews and used the phenomenographic method to analyze them. Four themes emerged from the data: 1) Being in contact with one’s own moving body; 2) Increased awareness of movement experiences; 3) Interrelationship between physiotherapist and patient; and 4) Better understanding of movement awareness. These themes varied by four descriptive ca…
University Teachers’ Conceptions of Their Role as Developers of Technology-Rich Learning Environments
2017
This phenomenographic study examines how a diverse group of university teachers conceptualised their role as developers of technology-rich learning environments at one university in Finland. The research findings illustrate a variety of conceptions. Five qualitatively different ways of understanding teachers’ roles regarding the development of technology-rich learning environments were found: 1) innovator, 2) early adopter, 3) adaptive, 4) sceptic and 5) late adopter. In order to connect the whole set of interconnected roles to a theory of change, Everett Rogers’ innovation diffusion theory was exploited in the last phase of analysis. Finally, hierarchically structured categories were creat…
Dal 15M al 24M: il maggio spagnolo da Democracia Real Ya (DRY) a Podemos
2015
Gli elementi che indignarono gli aderenti al movimento del 15M erano connessi alla politica dettata dall’austerity, alla disoccupazione record, alla precarizzazione dei giovani con l’incremento dei contratti a termine, alle misure di ristrutturazione e riduzione dello Stato sociale, attuate allora dal Governo Zapatero su pressione di BCE e FMI, e appoggiate dal Partito Popolare. Un forte sdegno investiva inoltre una classe politica percepita come altamente corrotta in un Paese in crisi (nel 2009 – c’erano stati ben 730 processi pendenti a carico di amministratori pubblici, con il primato del PSOE con 264 casi di corruzione aperti, seguito dai 200 casi del PP). Già nel giugno 2011 si assiste…
2. tipa cukura diabēta pacientu individualizēta terapija un tās nozīmēšanas kritēriji atbilstoši fenotipam
2015
2.tipa cukura diabēts ir hroniska slimība,kuras izplatība strauji pieaug visā pasaulē.Neraugoties uz izstrādātām vadlīnijām ārstiem,kā sākt2.tipaCD ārstēšanu,ne visi pacienti sasniedz mērķa glikēmiju un glikēta hemoglobīna(HbA1c)līmeni.Izpētīti228akūti hospitalizēti 2.tipaCD pacienti,kuri ārstējās no2013.gada janvāra līdz2014.gada septembrim.Liela uzmanība pievērsta pacientu bioķīmiskajiem radītājiem:triglicerīdi(TG), c-peptīds,HbA1c,GFĀ,ĶMI,ārstam,kas ārstēja noteiktu pacientu,terapijas izvēlei,pacientam izrakstoties no stacionāra. Fenotipiski pacienti sadalīti četrās grupās.Pirmajā grupā bija73pacienti ar hronisku nieru slimību(GFĀ30 kg/m2),66cilvēki bija vecāka gadagājuma pacientu grupā(…