Search results for "Flank"
showing 10 items of 22 documents
Asymmetric boudins as shear sense indicators—an assessment from field data
2003
Asymmetric boudins are potential but problematic shear sense indicators. They can be divided into two groups, with slip on the inter-boudin surface that is either synthetic (S-slip) or antithetic (A-slip) with respect to bulk shear sense. Since both groups have mirror-image symmetry, independent geometric criteria are needed to distinguish them if they are to be used as shear sense indicators. Investigation of asymmetric boudins in trains parallel to the main foliation from the Kaoko Belt in Namibia and elsewhere indicate that the geometry of both groups is in most cases different. Shearband boudins (formed by S-slip) have a long, curved lenticular shape and large relative displacement and …
Alteration-Induced Volcano Instability at La Soufrière de Guadeloupe (Eastern Caribbean)
2021
International audience; Volcanoes are unstable structures that deform laterally and frequently experience mass wasting events. Hydrothermal alteration is often invoked as a mechanism that contributes significantly to volcano instability. We present a study that combines laboratory experiments, geophysical data, and large-scale numerical modeling to better understand the influence of alteration on volcano stability, using La Soufrière de Guadeloupe (Eastern Caribbean) as a case study. Laboratory experiments on variably altered (advanced argillic alteration) blocks show that uniaxial compressive strength, Young's modulus, and cohesion decrease as a function of increasing alteration, but that …
New insights on the Carburangeli Cave speleogenesis: a flank margin cave in Northern Sicily (Italy)
2022
Flank margin caves form in coastal regions by mixing dissolution. Their development is controlled by the position of the freshsalt water mixing boundary, which in turn, is related to sea-level position. They are characterized by a typical cave pattern and cave-wall morphologies and represent good indicators of past sea levels. This contribution shows the results of recent studies conducted in the Carburangeli Cave, a small sub-horizontal cavity developed in Northern Sicily, close to Palermo. This cave was firstly known for paleontological and archaeological findings and for these reasons, along with its speleological and biological interest, a Nature Reserve has been instituted by the Sicil…
Technique and results of the retroperitoneoscopic adrenalectomy via a lumbar approach
1998
Introduction: Since 1992, endoscopic techniques have been used increasingly in adrenal-gland surgery. In the present paper, the technique of the retroperitoneoscopic adrenalectomy via a lumbar approach is described. Methods: The patient is placed in a lateral decubitus position. In the first step, a dilatation trocar is introduced in the retroperitoneal space to create an artificial cavity. The dilatation trocar is replaced by a blocking trocar to close off the operating field. After insufflation of CO2, two additional trocars are introduced in the area of the conventional flank incision. Adrenalectomy is performed via these ports. Once the adrenal gland is completely mobilized, it is inser…
Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29
2002
Abstract ERp29 is a soluble protein localized in the endoplasmic reticulum (ER) of eukaryotic cells, which is conserved in all mammalian species. The N-terminal domain of ERp29 displays sequence and structural similarity to the protein disulfide isomerase despite the lack of the characteristic double cysteine motif. Although the exact function of ERp29 is not yet known, it was hypothesized that it may facilitate folding and/or export of secretory proteins in/from the ER. ERp29 is induced by ER stress, i.e. accumulation of unfolded proteins in the ER. To gain an insight into the mechanisms regulating ERp29 expression we have cloned and characterized the rat ERp29 gene and studied in details …
On the Influence of the Radius Between Face and Flank on the Tool Life of Sintered Carbides
1985
Experimental investigations carried out by the authors in interrupted cutting, show that if the cutting edge survives to few impacts, then fracture will take place to very high number of impacts. Early fractures can be explained by assuming the presence of microscopic defects on the tool edge; a longer life can be referred to an increase tool strengthness due to rounding of the edge as a consequence of the wear process. In order to study the effects of the rounding of the edge, experimental tests have been carried out on several inserts of sintered carbides with different values of the radius of the edge between face and flank obtained by a tumbling process. The results show that the greate…
Role and importance of polymorphisms with respect to DNA methylation for the expression of CYP2E1 enzyme
2014
Different individuals possess slightly different genetic information and show genetically-determined differences in several enzyme activities due to genetic variability. Following an integrated approach, we studied the polymorphisms and methylation of sites contained in the 5' flanking region of the metabolizing enzyme CYP2E1 in correlation to its expression in both tumor and non-neoplastic liver cell lines, since to date little is known about the influence of these (epi)genetic elements in basal conditions and under induction by the specific inductor and a demethylating agent. In treated cells, reduced DNA methylation, assessed both at genomic and gene level, was not consistently associate…
Chromatin structure of the 5′ flanking region of the yeastLEU2 gene
1989
The chromatin structure of theLEU2 gene and its flanks has been studied by means of nuclease digestion, both with micrococcal nuclease and DNase I. The gene is organized in an array of positioned nucleosomes. Within the promoter region, the nucleosome positioning places the regulatory sequences, putative TATA box and upstream activator sequence outside the nucleosomal cores. The tRNA3 Leu gene possesses a characteristic structure and is protected against nucleases. Most of the 5′ flank is sensitive to DNase I digestion, although no clear hypersensitive sites were found. The chromatin structure is independent of either the transcriptional state of the gene or the chromosomal or episomal loca…
Tool Wear and Damage
2008
This chapter provides comprehensive knowledge regarding tool wear mechanisms and characterizes their physical fundamentals. Adhesion, abrasion, diffusion and oxidation are selected as predominant mechanisms controlling tool wear, depending on the mechanical and thermal conditions at the rake and flank faces. The analytical models describing the wear rate and volumetric material loss for different wear mechanisms are provided. The tool wear indicators related to crater, flank and notch wear specified in ISO 3685 are presented for both flat-faced and grooved tools. Tool life is defined and corresponding models, including the influence of cutting speed, feed and the depth of cut, are derived. …
Neuronal precursor-specific activity of a human doublecortin regulatory sequence.
2005
The doublecortin (DCX) gene encodes a 40-kDa microtubule-associated protein specifically expressed in neuronal precursors of the developing and adult CNS. Due to its specific expression pattern, attention was drawn to DCX as a marker for neuronal precursors and neurogenesis, thereby underscoring the importance of its promoter identification and promoter analysis. Here, we analysed the human DCX regulatory sequence and confined it to a 3.5-kb fragment upstream of the ATG start codon. We demonstrate by transient transfection experiments that this fragment is sufficient and specific to drive expression of reporter genes in embryonic and adult neuronal precursors. The activity of this regulator…