Search results for "Frame"
showing 10 items of 1767 documents
Performance and convergence in municipal waste treatment in the European Union.
2019
This paper assesses performance and convergence in the treatment of municipal waste by the members of the European Union-27 (EU-27) during the period 1995-2016. First, a composite indicator of performance -including landfill, incineration, recycling, and composting and digestion as treatment operations- is computed with Data Envelopment Analysis and Multi-Criteria-Decision-Making techniques at country and year levels. Then, convergence is assessed using the techniques proposed by Phillips and Sul (2007, 2009) and, more recently, by Kong et al. (2017). The best performers are Central and Northern European countries such as Denmark, Austria and Germany, whereas the worst are some Eastern Euro…
Two Antigenic Peptides from Genes m123 and m164 of Murine Cytomegalovirus Quantitatively Dominate CD8 T-Cell Memory in the H-2 d Haplotype
2001
ABSTRACT The importance of CD8 T cells for the control of cytomegalovirus (CMV) infection has raised interest in the identification of immunogenic viral proteins as candidates for vaccination and cytoimmunotherapy. The final aim is to determine the viral “immunome” for any major histocompatibility complex class I molecule by antigenicity screening of proteome-derived peptides. For human CMV, there is a limitation to this approach: the T cells used as responder cells for peptide screening are usually memory cells that have undergone in vivo selection. On this basis, pUL83 (pp65) and pUL123 (IE1 or pp68 to -72) were classified as immunodominant proteins. It is an open question whether this li…
Processing and Presentation of Murine Cytomegalovirus pORFm164-Derived Peptide in Fibroblasts in the Face of All Viral Immunosubversive Early Gene Fu…
2002
ABSTRACTCD8 T cells are the principal effector cells in the resolution of acute murine cytomegalovirus (mCMV) infection in host organs. This undoubted antiviral and protective in vivo function of CD8 T cells appeared to be inconsistent with immunosubversive strategies of the virus effected by early (E)-phase genesm04,m06, andm152. The so-called immune evasion proteins gp34, gp48, and gp37/40, respectively, were found to interfere with peptide presentation at different steps in the major histocompatibility complex (MHC) class I pathway of antigen processing and presentation in fibroblasts. Accordingly, they were proposed to prevent recognition and lysis of infected fibroblasts by cytolytic T…
A novel transmembrane domain mediating retention of a highly motile herpesvirus glycoprotein in the endoplasmic reticulum
2010
Gene m164 of murine cytomegalovirus belongs to the large group of 'private' genes that show no homology to those of other cytomegalovirus species and are thought to represent 'host adaptation' genes involved in virus-host interaction. Previous interest in the m164 gene product was based on the presence of an immunodominant CD8 T-cell epitope presented at the surface of infected cells, despite interference by viral immune-evasion proteins. Here, we provide data to reveal that the m164 gene product shows unusual features in its cell biology. A novel strategy of mass-spectrometric analysis was employed to map the N terminus of the mature protein, 107 aa downstream of the start site of the pred…
Identification of a Kd-restricted antigenic peptide encoded by murine cytomegalovirus early gene M84
2000
The two sister cytomegaloviruses (CMVs), human and murine CMV, have both evolved immune evasion functions that interfere with the major histocompatibility complex class I (MHC-I) pathway of antigen processing and presentation and are effectual in the early (E) phase of virus gene expression. However, studies on murine CMV have shown that E-phase immune evasion is leaky. An E-phase protein involved in immune evasion, namely m04-gp34, was found to simultaneously account for an antigenic peptide presented by the MHC-I molecule Dd. Recent work has demonstrated the induction of protective immunity specific for the E-phase protein M84-p65, one of two murine CMV homologues of the human CMV matrix …
DNMT3A mutations Predict for Inferior Outcome in NPM1-Wildtype and Molecular Unfavorable Cytogenetically-Normal Acute Myeloid Leukemia: A Study of th…
2011
Abstract Abstract 415 Background: Alteration of DNA methylation, a hallmark of epigenetic modification, is currently discussed as one important pathomechanism in leukemogenesis. Using a next-generation sequencing approach, a frameshift mutation of the gene encoding the DNA methyltransferase (DNMT3A) in an acute myeloid leukemia (AML) case was identified. DNMT3A catalyses the addition of a methyl group to the cytosine residue of CpG dinucleotides, thereby affecting promoter methylation status and gene expression. Subsequent sequencing analysis in an independent cohort of 288 AML patients (pts) revealed DNMT3A mutations (DNMT3Amut) in 22% of the pts; mutations were associated with intermediat…
Did We Miss the Social Commentary? Responding to Borat on Youtube
2011
Ever since the fictitious Kazakh journalist Borat Sagdiyev became an icon of contemporary popular culture, many questions have arisen about the reception of Borat by the general public. Namely, how common people have created a shared representation of Borat and how the complicated character and comedic manner undertaken by Sacha Baron Cohen is being deciphered. To address these questions that, surely, also could be asked concerning other international media products, this article deals with the reception of Borat the character on YouTube. In particular, the viewers’ reaction to the YouTube video titled “The Best of Borat” is analysed. This video has been viewed more than seven million times…
Enhancing Privacy and Authorization Control Scalability in the Grid through Ontologies
2009
The use of data Grids for sharing relevant data has proven to be successful in many research disciplines. However, the use of these environments when personal data are involved (such as in health) is reduced due to its lack of trust. There are many approaches that provide encrypted storages and key shares to prevent the access from unauthorized users. However, these approaches are additional layers that should be managed along with the authorization policies. We present in this paper a privacy-enhancing technique that uses encryption and relates to the structure of the data and their organizations, providing a natural way to propagate authorization and also a framework that fits with many u…
Designing Frame Relay WAN Networks with Trade-Off between Link Cost and Performance
2014
This paper is focused on the problem of designing a Wide Area Network topology with trade-off between link cost and response time to users. The L2 technology chosen for the research is a Frame Relay based solution. The link capacities in the network and the routes used by packets are determined in a way to minimize network cost and response time at the same time. In FR networks link capacity corresponds directly to CIR parameter which makes the presented numerical results very useful in practice, especially during preliminary network design in the Design Phase of the PPDIOO methodology.
Marinesco-Sjögren syndrome caused by a new SIL1 frameshift mutation
2015
no abstract available