Search results for "Frau"
showing 10 items of 105 documents
Assessing multiple sources of data to detect illegal fishing, trade and mislabelling of elasmobranchs in Greek markets
2020
Abstract Elasmobranchs, extremely charismatic and threatened animals, still are an important economic source for fishers in many parts of the world, providing significant income through trade. Even though Greek seas host at least 67 elasmobranch species, our knowledge about their biology and ecology is to a large extent unknown. In the present study the integration of conventional (legislation, official data from fisheries landings and fish market value and import/export data) and unconventional (social media) sources of data, accompanied with the use of genetics, aim at outlining the elasmobranch fisheries and trade in Greece and identifying “weak spots” that sabotage their conservation. R…
Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
2020
TP53 missense mutations leading to the expression of mutant p53 oncoproteins are frequent driver events during tumorigenesis. p53 mutants promote tumor growth, metastasis and chemoresistance by affecting fundamental cellular pathways and functions. Here, we demonstrate that p53 mutants modify structure and function of the Golgi apparatus, culminating in the increased release of a pro-malignant secretome by tumor cells and primary fibroblasts from patients with Li-Fraumeni cancer predisposition syndrome. Mechanistically, interacting with the hypoxia responsive factor HIF1α, mutant p53 induces the expression of miR-30d, which in turn causes tubulo-vesiculation of the Golgi apparatus, leading …
Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatri…
2017
Heritable predisposition is an important cause of cancer in children and adolescents. Although a large number of cancer predisposition genes and their associated syndromes and malignancies have already been described, it appears likely that there are more pediatric cancer patients in whom heritable cancer predisposition syndromes have yet to be recognized. In a consensus meeting in the beginning of 2016, we convened experts in Human Genetics and Pediatric Hematology/Oncology to review the available data, to categorize the large amount of information, and to develop recommendations regarding when a cancer predisposition syndrome should be suspected in a young oncology patient. This review su…
Validation of a questionnaire of attributions to the detection of coincidences in academic work
2019
El plagio como tema de investigación en el contexto universitario no ha cesado de ser una preocupación constante debido a sus múltiples repercusiones. El presente estudio describe el proceso seguido en la validación del Cuestionario de atribuciones para la detección de coincidencias en trabajos académicos (CUDECO), cuya finalidad es evaluar la relevancia que tiene citar correctamente y detectar las causas que llevan a cometer plagio. A partir de una muestra de 2,331 estudiantes, se realiza un anális is de la fiabilidad como consistencia interna y un análisis factorial exploratorio (AFE) del instrumento. El análisis de la fiabilidad lleva a proponer un reajuste en el cuestionario inicialment…
Compensation of Oxygen Transmittance Effects for Proximal Sensing Retrieval of Canopy–Leaving Sun–Induced Chlorophyll Fluorescence
2018
Estimates of Sun–Induced vegetation chlorophyll Fluorescence (SIF) using remote sensing techniques are commonly determined by exploiting solar and/or telluric absorption features. When SIF is retrieved in the strong oxygen (O 2 ) absorption features, atmospheric effects must always be compensated. Whereas correction of atmospheric effects is a standard airborne or satellite data processing step, there is no consensus regarding whether it is required for SIF proximal–sensing measurements nor what is the best strategy to be followed. Thus, by using simulated data, this work provides a comprehensive analysis about how atmospheric effects impact SIF estimations on proximal sensing, regarding: (…
Una visión actualizada del instituto de la responsabilidad tributaria y su incidencia en los presupuestos de hecho por participación en actos ilícitos
2018
La tesis doctoral titulada “Una visión actualizada del instituto de la responsabilidad tributaria y su incidencia en los presupuestos de hecho por participación en actos ilícitos” tiene por objeto de estudio el análisis de la figura de la responsabilidad tributaria por causar o colaborar activamente en la comisión de una infracción tributaria. Nos encontramos en presencia de una institución jurídica en virtud de la cual el legislador tributario consigue situar junto al deudor principal de una obligación tributaria a otro sujeto que, aun siendo ajeno al hecho imponible devengado por el primero, no obstante, como consecuencia de la realización de un concreto presupuesto de hecho vinculado con…
Derecho tributario y defraudación fiscal: Un análisis psicosocial de la conducta de tributación.
2016
En este estudio se exponen los resultados de una serie de trabajos e investigaciones relacionados con la tributación y el fraude fiscal. A través de una amplia revisión de la literatura existente se examinan los modelos y estudios clásicos, así como los puntos de vista actuales sobre los determinantes psicosociales del comportamiento tributario. Los cambios demográficos, económicos y políticos de principios del siglo XXI han obligado a los Estados modernos a hacer un notable esfuerzo por mejorar el nivel de bienestar social. La capacidad de los gobiernos para obtener ingresos de forma eficiente es de vital importancia para lograr los fines de un Estado social, y para ello es necesario emple…
Primary Orbital Liposarcoma in Li-Fraumeni Cancer Family Syndrome: A Case Report
2005
Aims and background The aim of this study was to describe a case of primary orbital liposarcoma in Li-Fraumeni syndrome. Methods and study design In July 1998 a 20-year-old woman with a histological diagnosis of orbital myxoid liposarcoma underwent surgical treatment in our department. Since the patient's family pedigree met the clinical criteria for the diagnosis of LFS, molecular analysis was performed, which resulted in a molecular profile consistent with Li-Fraumeni syndrome. Results The patient underwent orbital exenteration extended to the upper eyelid; surgical reconstructive steps were performed to permit placement of an orbital prosthesis. Two years after primary surgery the patien…
Usability and Trust in E-Banking
2007
This study assessed the role of usability in trust of e-banking services. A questionnaire was administered to 185 Italian undergraduate working students who volunteered for the experiment (M age = 30.5 yr., SD = 3.1). Participants were differentiated on computer ability (Expert, n=104; Nonexpert, n = 81) and e-banking use (User, n = 93; Nonusers, n = 92). Analysis showed that the website usability of e-banking services did not play a very important role for the User group. Instead, institution-based trust, e.g., the trust in the security policy of the Web merchant, customers, and the overall trust of the bank were the crucial factors in the adoption of e-banking. © Psychological Reports 200…
Usufruit temporaire et abus de droit
2020
International audience; Note sous Cour de cassation (com.), 4 décembre 2019, n° 18-19.969 (F-D), A.