Search results for "G1"
showing 10 items of 717 documents
CASE STUDY REGARDING THE FINANCIAL PERFORMANCE BASED ON RATES OF RETURN, FOR COMPANIES LISTED ON BUCHAREST STOCK EXCHANGE, ACTING IN MINING AND QUARR…
2013
Analysing the relationships between elements of an enterprise's financial statements, especially between elements from the balance sheet and those from the profit and loss account, the rates of return adds greater utility to the consumers of financial information, offering the possibility to make comparisons over time and space as well as to make reference to internal and external rates. Considering the companies listed on Bucharest Stock Exchange among the best performing, due to the high requirements imposed by a stock market, in this paper has been analyzed the way the financial crisis affected the financial performance in Mining and Quarrying Domain.
Perspectives of tax reforms in Croatia: expert opinion survey
2014
In order to shape tax reform it is necessary objectively to assess the current stateof-the- art of and of the outlook for the tax system. After having reviewed all previous reforms in the light of the consumption-based (interest- adjusted) concept of direct taxation, which was almost systematically implemented in Croatia in 1994, we present the results of a broad expert opinion survey about the Croatian tax system. The most interesting results suggest the maintenance/(re)introduction of different tax incentives and reduced VAT rates, rejection of a flat tax as well as decrease of tax brackets, an increase in alcohol and tobacco duties, the introduction of a financial activities tax, a furth…
School choice criteria and school segregation in the city of Valencia
2022
El objetivo de este estudio es conocer cuáles son los patrones que intervienen en la elección de centro escolar y detectar los factores sociodemográficos, económicos y de localización que subyacen tras ellos. Para ello, se ha realizado una encuesta a la demanda potencial de los centros públicos que imparten el segundo ciclo de educación infantil en la ciudad de Valencia. Los resultados indican que el principal criterio de elección de centro escolar es la proximidad entre el hogar y el colegio, y que el modo de desplazamiento más utilizado es el peatonal. Sin embargo, los costes de desplazamiento y los medios utilizados están directamente relacionados con las características socioeconómicas …
G124 e ZEN2
2023
Lavorare nelle periferie, oltre a rispondere alle esigenze molto concrete che queste parti urbane manifestano, sembra essere il modo più approfondito per conoscere la realtà di oggi. Cioè scegliere la periferia coincide con la volontà di indagare quella parte urbana che ha maggiori potenzialità e quindi più gradi di sperimentazione. L’argomento trattato include il grande tema della forestazione urbana, sapendo però cogliere una differente applicazione riguardo alle peculiarità degli spazi urbani. Bisogna sapere distinguere l’eventuale trasformazione di una generica strada in viale alberato, in una parte della città consolidata, da interventi molto più consistenti in prossimità dei margini u…
As2O3-induced oxidative stress and cycle progression in a human intestinal epithelial cell line (Caco-2)
2007
Foods and drinking water are the main routes for human exposure to inorganic arsenic, the intestinal epithelium being the first barrier against such exogenous toxicants. The present study evaluates the effect of As(III) (0.5-25 microM) upon Caco-2 cells as an intestinal epithelia model. Cell viability, intracellular formation of reactive oxygen species (ROS), mitochondrial membrane potential (Deltapsim) changes, and cell cycle distribution in exposed cultures were evaluated. The intracellular production of ROS was seen to increase in a non-dose dependent manner at all concentrations tested, with impairment of cell mitochondrial enzyme function secondary to a loss of Deltapsim. Concentration…
Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of Bcl-…
2002
This report is focused on the apoptotic effect induced by MG132, an inhibitor of 26S proteasome, in human hepatoma HepG2 cells. The results were compared with those obtained with non-transformed human Chang liver cells. MG132 reduced the viability of HepG2 cells in a time- and dose-dependent manner. The effect was in tight connection with the induction of apoptosis, as indicated by fluorescence microscopy and cytometric analysis, and was accompanied by a remarkable increase in the production of H2O2 and a reduction in mitochondrial transmembrane potential (Deltapsim). In addition cell death was prevented by antioxidants such as GSH, N-acetylcysteine or catalase. Western blot analysis showed…
Holes in the Dike: the global savings glut, U.S. house prices and the long shadow of banking deregulation
2015
We explore empirically how capital inflows into the US and financial deregulation within the United States interacted in driving the run-up (and subsequent decline) in US housing prices over the period 1990-2010. To obtain an ex ante measure of financial liberalization, we focus on the history of interstate-banking deregulation during the 1980s, i.e. prior to the large net capital inflows into the US from China and other emerging economies. Our results suggest a long shadow of deregulation: in states that opened their banking markets to out-of-state banks earlier, house prices were more sensitive to capital inflows. We provide evidence that global imbalances were a major positive funding sh…
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy
2014
Macroautophagy is a degradative pathway that sequesters and transports cytosolic cargo in autophagosomes to lysosomes, and its deterioration affects intracellular proteostasis. Membrane dynamics accompanying autophagy are mostly elusive and depend on trafficking processes. RAB GTPase activating proteins (RABGAPs) are important factors for the coordination of cellular vesicle transport systems, and several TBC (TRE2-BUB2-CDC16) domain-containing RABGAPs are associated with autophagy. Employing C. elegans and human primary fibroblasts, we show that RAB3GAP1 and RAB3GAP2, which are components of the TBC domain-free RAB3GAP complex, influence protein aggregation and affect autophagy at basal an…
The b1 isoform of protocadherin-gamma (Pcdhgamma) interacts with the microtubule-destabilizing protein SCG10.
2004
Due to their structural characteristics and their diversity, the 22 members of the protocadherin-gamma (Pcdhgamma) family have been suggested to contribute to the establishment of specific connections in the nervous system. Here, we focus on a single isoform, Pcdhgamma-b1. Its expression is found in different brain regions and in developing spinal cord it is restricted to scattered cells, whereas all cells are labeled using an antibody that recognizes all Pcdhgamma isoforms. As a first step to understanding the signaling mechanisms downstream of Pcdhgamma, we identify the microtubule-destabilizing protein SCG10 as a cytoplasmic interactor for Pcdhgamma-b1 and other isoforms of the Pcdhgamma…
Accesibilidad y provisión de servicios de interés general en las áreas rurales de la Unión Europea: un análisis a partir del Eurobarómetro
2014
La finalidad de este trabajo es ofrecer un estado de la cuestión sobre el acceso y provisión de Servicios de Interés General (SeIG) en las áreas rurales de la Unión Europea. Se identifican fuerzas de cambio, oportunidades y dificultades relativas a los SeIG que pueden contribuir a impulsar o ralentizar los procesos de desarrollo rural. Se lleva a cabo una revisión de las principales aproximaciones teóricas y se presentan diversos análisis empíricos a partir de los escasos datos homogéneos disponibles. A partir del conocimiento adquirido se formula un conjunto de reflexiones sobre la función de los SeIG en los procesos de cambio rural en la UE.