Search results for "GASES"
showing 10 items of 1098 documents
NFAT transcription factors in control of peripheral T cell tolerance.
2006
The Ca++-regulated calcineurin/NFAT cascade is one of the crucial signalling pathways that controls adaptive immunity. However, a number of novel experimental data suggest that, in addition to their role in T cell activation, NFATc transcription factors play also a decisive role in the generation of peripheral tolerance against self-antigens. This function of NFATc factors is mediated by controlling activation-induced cell death and clonal anergy of T helper cells and the activity of regulatory T cells. The multi-functional role of NFATc proteins characterize these transcription factors as key regulators of immunological tolerance and, if dysregulated, of development of autoimmune diseases.
A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling.
2011
Background & Aims Transforming growth factor (TGF)-β signaling, which is down-regulated by the E3 ubiquitin ligase Smad ubiquitin regulating factor 2 (Smurf2), promotes development of cancer. We identified a splice variant of Smurf2 (ΔE2Smurf2) and investigated its role in colon carcinogenesis in mice. Methods Colitis-associated colon cancer was induced in mice by administration of azoxymethane, followed by 3 cycles of oral administration of dextran sodium sulfate. Messenger RNA levels of Smurf2 in colon tumors and control tissue were measured by quantitative polymerase chain reaction; lymphocyte and cytokine levels were measured in tumor and tissue samples. Results Tumor-infiltrating CD4 +…
Super-Exponential Size Advantage of Quantum Finite Automata with Mixed States
2008
Quantum finite automata with mixed states are proved to be super-exponentially more concise rather than quantum finite automata with pure states. It was proved earlier by A.Ambainis and R.Freivalds that quantum finite automata with pure states can have exponentially smaller number of states than deterministic finite automata recognizing the same language. There was a never published "folk theorem" proving that quantum finite automata with mixed states are no more than super-exponentially more concise than deterministic finite automata. It was not known whether the super-exponential advantage of quantum automata is really achievable. We use a novel proof technique based on Kolmogorov complex…
Comparative genomics and protein domain graph analyses link ubiquitination and RNA metabolism.
2006
The human gene parkin, known to cause familial Parkinson disease, as well as several other genes, likely involved in other neurodegenerative diseases or in cancer, encode proteins of the RBR family of ubiquitin ligases. Here, we describe the structural diversity of the RBR family in order to infer their functional roles. Of particular interest is a relationship detected between RBR-mediated ubiquitination and RNA metabolism: a few RBR proteins contain RNA binding domains and DEAH-box RNA helicase domains. Global protein domain graph analyses demonstrate that this connection is not RBR-specific, but instead many other proteins contain both ubiquitination and RNA-related domains. These protei…
Noise correlations of the ultracold Fermi gas in an optical lattice
2008
In this paper we study the density noise correlations of the two component Fermi gas in optical lattices. Three different type of phases, the BCS-state (Bardeen, Cooper, and Schieffer), the FFLO-state (Fulde, Ferrel, Larkin, and Ovchinnikov), and BP (breach pair) state, are considered. We show how these states differ in their noise correlations. The noise correlations are calculated not only at zero temperature, but also at non-zero temperatures paying particular attention to how much the finite temperature effects might complicate the detection of different phases. Since one-dimensional systems have been shown to be very promising candidates to observe FFLO states, we apply our results als…
Reduction of the number of spectral bands in Landsat images: a comparison of linear and nonlinear methods
2006
We describe some applications of linear and nonlinear pro- jection methods in order to reduce the number of spectral bands in Land- sat multispectral images. The nonlinear method is curvilinear component analysis CCA, and we propose an adapted optimization of it for image processing, based on the use of principal-component analysis PCA, a linear method. The principle of CCA consists in reproducing the topol- ogy of the original space projection points in a reduced subspace, keep- ing the maximum of information. Our conclusions are: CCA is an im- provement for dimension reduction of multispectral images; CCA is really a nonlinear extension of PCA; CCA optimization through PCA called CCAinitP…
An efficient swap algorithm for the lattice Boltzmann method
2007
During the last decade, the lattice-Boltzmann method (LBM) as a valuable tool in computational fluid dynamics has been increasingly acknowledged. The widespread application of LBM is partly due to the simplicity of its coding. The most well-known algorithms for the implementation of the standard lattice-Boltzmann equation (LBE) are the two-lattice and two-step algorithms. However, implementations of the two-lattice or the two-step algorithm suffer from high memory consumption or poor computational performance, respectively. Ultimately, the computing resources available decide which of the two disadvantages is more critical. Here we introduce a new algorithm, called the swap algorithm, for t…
Parallelization of Cellular Automata for Surface Reactions
2002
We present a parallel implementation of cellular automata to simulate chemical reactions on surfaces. The scaling of the computer time with the number of processors for this parallel implementation is quite close to the ideal T/P, where T is the computer time used for one single processor and P the number of processors. Two examples are presented to test the algorithm, the simple A+B->0 model and a realistic model for CO oxidation on Pt(110). By using large parallel simulations, it is possible to derive scaling laws which allow us to extrapolate to even larger system sizes and faster diffusion coefficients allowing us to make direct comparisons with experiments.
Quantum phases in a resonantly-interacting Bose-Fermi mixture
2005
X-ray versus Ultraviolet Irradiation of Astrophysical Ice Analogs Leading to Formation of Complex Organic Molecules
2019
In astrochemistry, complex organic molecules (COMs) are defined as species with at least one C atom and six or more atoms in total. More than 70 COMs were detected toward various interstellar and c...