Search results for "GDE"

Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency

2016

International audience; N-terminal acetylation is a common protein modification in eukaryotes associated with numerous cellular processes. Inherited mutations in NAA10, encoding the catalytic subunit of the major N-terminal acetylation complex NatA have been associated with diverse, syndromic X-linked recessive disorders, whereas de novo missense mutations have been reported in one male and one female individual with severe intellectual disability but otherwise unspecific phenotypes. Thus, the full genetic and clinical spectrum of NAA10 deficiency is yet to be delineated. We identified three different novel and one known missense mutation in NAA10, de novo in 11 females, and due to maternal…

Le dépôt de bronzes du site fluvial de La Motte à Agde (Hérault)

2007

Die Untersuchung der Flusssiedlung La Motte bei Agde (Hérault, Frankreich) im Jahre 2004 hat zur Ent- deckung eines bedeutenden, unberührten Depots von Bronzeobjekten geführt. Das Ensemble wurde noch nicht vollständig restauriert, doch erlauben die bereits untersuchten 330 Objekte eine vorläufige, zusam- menfassende Vorlage. Es finden sich vor allem Kleidungs- und Trachtelemente, durch die das reiche Zere- monialkleid einer Frau aus dem Languedoc der frühen Eisenzeit (8. oder erste Hälfte des 7. Jahrhunderts v.Chr.) rekonstruiert werden konnte. Die typologische Untersuchung zeigt, dass die Tracht aus einer Mischung von Einflüssen aus dem westlichen und östlichen Languedoc, der Prov…

Agde, dépôt de la Motte (Hérault)

2013

Vil økt fysisk aktivitet kunne redusere andelen trygdemottakere? : En case-studie basert på deltakere ved Aktiv på dagtid, Aust-Agder

2018

Masteroppgave offentlig politikk og ledelse ME502 - Universitetet i Agder 2018 This study is based on Aktiv pådagtid as an case study. The purpose of this study is to investigate the relationship between increased participation in physical activities directed by Aktiv på dagtid and the participants status in relation to working life. To better understand the relationship between these two variables, the study include three possible predictors:health, social support and self-efficacy.Thisstudy use a paper-based survey with 144 respondents, which represent the participants atAktiv på dagtid, who are at theage between 16-70, receive social security benefits and resides in the municipalities of…

LogDet divergence-based metric learning with triplet constraints and its applications.

2014

How to select and weigh features has always been a difficult problem in many image processing and pattern recognition applications. A data-dependent distance measure can address this problem to a certain extent, and therefore an accurate and efficient metric learning becomes necessary. In this paper, we propose a LogDet divergence-based metric learning with triplet constraints (LDMLT) approach, which can learn Mahalanobis distance metric accurately and efficiently. First of all, we demonstrate the good properties of triplet constraints and apply it in LogDet divergence-based metric learning model. Then, to deal with high-dimensional data, we apply a compressed representation method to learn…

How far are we from the valorization of waste-CO2 to formic acid via electrochemical routes for the applicative scale?

To date, the decarbonization of the world economy and storage and production of energy from alternative C-based sources is considered a relevant topic. The electrochemical conversion of CO2 has been widely investigated since the 1870s as a promising strategy to convert waste-CO2 into value-added chemicals [1,2]. Recently, it was highlighted that, among the several emerging technologies for CO2 conversion to value-added products on an applicative scale, electrochemical technologies are the closest to commercialization due to the numerous start-ups and established companies being invested in this area (e.g., Opus-12, Dioxide Material, and Carbon Recycling International) [3]. These technologie…

Upper bounds for the tightness of the $$G_\delta $$-topology

2021

We prove that if X is a regular space with no uncountable free sequences, then the tightness of its $$G_\delta $$ topology is at most the continuum and if X is, in addition, assumed to be Lindelof then its $$G_\delta $$ topology contains no free sequences of length larger then the continuum. We also show that, surprisingly, the higher cardinal generalization of our theorem does not hold, by constructing a regular space with no free sequences of length larger than $$\omega _1$$ , but whose $$G_\delta $$ topology can have arbitrarily large tightness.

Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sources.

2006

Aims To compare information on drug–drug interactions (DDIs) reported on two standard drug-related information sources (Summary of Product Characteristics and Drugdex system by Micromedex), by assessing the prevalence and predictors of potential DDI with proton pump inhibitors (PPIs) in general practice. Methods From the ‘Caserta-1’ Local Health-Service database, 156 general practitioners (GPs) were recruited. From more than 180 000 individuals registered on their lists, we selected patients receiving co-prescription of PPI and medications at interaction risk, according to the Italian Summary of Product Characteristics (SPC) of PPI and Drugdex information, during the year 2003. Thereafter, …

Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy.

2021

Gene-directed enzyme prodrug therapy (GDEPT) has been intensively studied as a promising new strategy of prodrug delivery, with its main advantages being represented by an enhanced efficacy and a reduced off-target toxicity of the active drug. In recent years, numerous therapeutic systems based on GDEPT strategy have entered clinical trials. In order to deliver the desired gene at a specific site of action, this therapeutic approach uses vectors divided in two major categories, viral vectors and non-viral vectors, with the latter being represented by chemical delivery agents. There is considerable interest in the development of non-viral vectors due to their decreased immunogenicity, higher…

Motherhood in the Context of Human Trafficking and Sexual Exploitation

2020

This book discusses motherhood of Nigerian and Romanian women in Italy and Romania, who are human trafficking victims for sexual purposes. It provides a broad gender approach to emerge on the phenomenon of human trafficking with an analytic perspective of all the social, cultural, legal and economic components that play an important role during all phases of motherhood. The book compares the motherhood of these two nationalities within a context of an illegal/legal status in the European territory. It reflects on the used terms of vulnerability, sexual exploitation, victim, resistance and resilience. This book enlightens scholars and students with a broad perspective on this complex phenome…