Search results for "GENERATOR"
showing 10 items of 426 documents
Quantitative online isolation of 68Ge from 68Ge/68Ga generator eluates for purification and immediate quality control of breakthrough
2013
The breakthrough of ⁶⁸Ge from a ⁶⁸Ge/⁶⁸Ga-generator is one of the most sensitive parameters in the context of the clinical application of ⁶⁸Ga-radiopharmaceuticals. The difficulty in its determination lies in the "spectroscopic invisibility" of ⁶⁸Ge within an excess of ⁶⁸Ga. The introduced method for determining the ⁶⁸Ge content of the ⁶⁸Ge/⁶⁸Ga-generator eluate involves the quantitative separation of ⁶⁸Ga from ⁶⁸Ge, using a cation-exchanger. The eluate contains ⁶⁸Ga free of ⁶⁸Ge, which can be determined immediately, i.e. prior to the application of the ⁶⁸Ga-radiopharmaceutical.
68Ge content quality control of 68Ge/68Ga-generator eluates and 68Ga radiopharmaceuticals – A protocol for determining the 68Ge content using thin-la…
2014
(68)Ge breakthrough from a (68)Ge/(68)Ga-generator appears to be one of the most critical parameters for the routine clinical application of this generator and (68)Ga-radiopharmaceuticals. We report a TLC-based (thin-layer chromatography) protocol which allows the (68)Ge breakthrough of a generator to be determined within 1 h post-initial elution. The protocol can also be adapted to allow the (68)Ge content of a (68)Ga-radiopharmaceutical preparation to be determined prior to in vivo application.
68 Ga‐Labelled Tropane Analogues for the Visualization of the Dopaminergic System
2020
Abstract The development of radiometal‐labelled pharmaceuticals for neuroimaging could offer great potential due to easier handling during labelling and availability through radionuclide generator systems. Nonetheless, to date, no such tracers are available for positron emission tomography, primarily owing to the challenge of crossing the blood–brain barrier (BBB) and loss of affinity through chelator attachment. We have prepared a variety of 68Ga‐labelled phenyltropanes showing that, through a simple hydrocarbon‐linker, it is possible to introduce a chelator onto the lead structure while maintaining its high affinity for hDAT (human dopamine transporter) and simultaneously achieving adequa…
Assessment of energy management technique for achieving the sustainable voltage level during grid outage of hydro generator interfaced DC Micro-Grid
2021
Abstract An appropriate energy management scheme is needed for the reliable and sustainable operation of DC microgrid. The energy management scheme of DC microgrid (MG) is mainly controlled by main energy resource of MG. Main energy resource needs to be dispatchable unit for forming the reference voltage within DC MG. In this work, a micro hydro generator (MHG) is considered as a dispatchable source for forming the sustainable voltage level of DC MG operating under the abnormal condition. In this work, the abnormality refers to the outage of solar PV due to intermittency during fluctuating load condition. But, due to mechanical time constant of MHG and rate of charging/discharging current l…
The influence of the stochastic features of the energy source on the design of an electromagnetic generator
2009
The purpose of this paper is to clarify in a general way how the unavoidable randomness of renewable energy sources influences the magnetic design of electric generator. A general model of electro magnetic generator based on the well known d-q axes analysis is given. The energy source is modelled as a stochastic variable and is included in the equations of the system. The equations are solved and, therefore, the energy output of the system is linked to the random characteristic of the energy source. As a result, the magnetic circuit and the parameters of the generator that maximize the energy extraction can be found and generally linked to the stochastic details of the source.