Search results for "GME"

Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?

2019

In most mammalian cells, the Golgi complex forms a continuous ribbon. In neurodegenerative diseases, the Golgi ribbon of a specific group of neurons is typically broken into isolated elements, a very early event which happens before clinical and other pathological symptoms become evident. It is not known whether this phenomenon is caused by mechanisms associated with cell death or if, conversely, it triggers apoptosis. When the phenomenon was studied in diseases such as Parkinson’s and Alzheimer’s or amyotrophic lateral sclerosis, it was attributed to a variety of causes, including the presence of cytoplasmatic protein aggregates, malfunctioning of intracellular traffic and/or alterations i…

Large-scale nonlinear dimensionality reduction for network intrusion detection

2017

International audience; Network intrusion detection (NID) is a complex classification problem. In this paper, we combine classification with recent and scalable nonlinear dimensionality reduction (NLDR) methods. Classification and DR are not necessarily adversarial, provided adequate cluster magnification occurring in NLDR methods like $t$-SNE: DR mitigates the curse of dimensionality, while cluster magnification can maintain class separability. We demonstrate experimentally the effectiveness of the approach by analyzing and comparing results on the big KDD99 dataset, using both NLDR quality assessment and classification rate for SVMs and random forests. Since data involves features of mixe…

Sargmezgla biopsijas izmantošana pacientēm ar agrīnas stadijas invazīvo krūts vēzi

2016

Problēmas aktualitāte. Sargmezglu biopsija ir minimāli invazīva reģionalās kontroles metode, kuras izmantošana var mazināt morbiditāti, saistītu ar citu, līdz 1994.gadam vienīgo, reģionālas kontroles metodi krūts vēža pacientēm - paduses limfmezglu disekciju. Pētījuma mērķis. Izprast korelāciju starp sargmezglu biopsiju un metastāzēm paduses limfmezglos pacientēm ar agrīnas stadijas invazīvu krūts vēzi. Materiāli un metodes. Pētījums ir aprakstošs retrospektīvs. Tika atlasītas un analizētas agrīno stādiju (I, IIA, IIB) krūts vēža pacientšu slimības vēstures Latvijas Onkoloģijas Centra un Patoloģijas Centra arhīvos, kuras laika posmā no 2010.gada janvāra līdz 2012.gada decembrim saņēma ķirur…

Trap-assisted studies of odd, neutron-rich isotopes from Tc to Pd

2012

We review the present and future of trap-assisted structure studies of odd, neutron-rich Tc, Ru, Rh and Pd isotopes at the limits of present experimental techniques. These nuclei of refractory elements are produced in light-particle induced fission and filtered by their mass number with the IGISOL mass separator. Further mass separation with the JYFLTRAP Penning trap system provides a clean, monoisotopic beam perfectly suited for precise nuclear spectroscopy. Connecting the IGISOL and the JYFLTRAP facilities to the recently installed MCC30/15 cyclotron opens new prospects for post-trap spectroscopy of very exotic, neutron-rich nuclei. peerReviewed

Micro-Raman study of red decorations in French faiences of the 18th and 19th centuries

2006

Obtaining the red color was a technical and economic challenge for the French faience manufactories in the 18th and 19th centuries. The tendency of the red hematite to turn into drab brown during the firing process explains the difficulty in obtaining this color. Red decorations in shards coming from the four production centers of faience manufacturing during this period—Rouen (northwest), Nevers (central), Thiviers (southwest) and Argonne (northeast)—have been studied by means of micro-Raman spectroscopy, scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Among them, Thiviers appears to be the leader thanks to a particular reddish sandstone called ‘Gres de T…

Guaranteed error bounds for linear algebra problems and a class of Picard-Lindelöf iteration methods

2012

This study focuses on iteration methods based on the Banach fixed point theorem and a posteriori error estimates of Ostrowski. Their application for systems of linear simultaneous equations, bounded linear operators, as well as integral and differential equations is considered. The study presents a new version of the Picard–Lindelöf method for ordinary differential equations (ODEs) supplied with guaranteed and explicitly computable upper bounds of the approximation error. The estimates derived in the thesis take into account interpolation and integration errors and, therefore, provide objective information on the accuracy of computed approximations.

Scaffolding self-regulated learning from causal-relations texts: Diagramming and self-assessment to improve metacomprehension accuracy?

2023

AbstractThe accuracy of students’ relative comprehension judgments when reading texts is typically rather low. This has been ascribed to students grounding their comprehension judgments on cues that are not diagnostic of their actual comprehension level. Asking students to complete causal diagrams—a diagramming scaffold—before judging comprehension has proved effective in providing them with more diagnostic cues and thereby fostered metacomprehension accuracy and self-regulated learning. However, there is still room for improvement. We investigated experimentally whether adding the instruction to students to self-assess their causal diagrams: (1) would lead to more accurate judgments than c…

Gestión empresarial y dinámica laboral en España

2015

El objetivo del presente artículo es plantear una serie de reflexiones sobre la dinámica labo- ral reciente en la economía española bajo el enfoque analítico de la segmentación laboral. Desde esta perspectiva, la situación y problemas del mercado laboral se explican por un conjunto de factores relacionados con las prácticas de gestión empresarial y no tanto por la regulación que limita la competencia en el mercado o las modalidades contractuales. Nues- tra conclusión es que es necesario superar el marco analítico restringido del enfoque econó- mico convencional e introducir otras dimensiones, que van más allá del mercado, para una mejor compresión de los problemas laborales. En este sentido…

The Analysis of Consumer Behavior in Relationship to a Global Brand in the Lodging Industry, Across Europe and North America Abstract: The world is c…

2011

Market Segmentation in the Decision Making Process in Tourism

2014

In this paper, I examine the responses of 154 tourists in relation to their predisposition to purchase and the patterns and habits that are usually decisive in the decision making process regarding tourism services or products. For this research, I conducted a selective direct research, whose purpose was to obtain a segmentation of consumers who purchase tourism services based on specific dimensions of behavior. This research also implied studying the behavior of current and potential customers who purchase travel services depending on several variables for establishing different consumption habits. Thus, to establish a more detailed image of the tourists who participated in this direct and…