Search results for "GW"
showing 10 items of 183 documents
Breast cancer genome-wide association studies: there is strength in numbers.
2012
Breast cancer (BC) is a heterogeneous disease that exhibits familial aggregation. Family linkage studies have identified high-penetrance genes, BRCA1, BRCA2, PTEN and TP53, that are responsible for inherited BC syndromes. Moreover, a combination of family-based and population-based approaches indicated that genes involved in DNA repair, such as CHEK2, ATM, BRIP and PALB2, are associated with moderate risk. Therefore, all of these known genes account for only 25% of the familial aggregation cases. Recently, genome wide association studies (GWAS) in BC revealed single nucleotide polymorphisms (SNPs) in five novel genes associated to susceptibility: TNRC9, FGFR2, MAP3K1, H19 and lymphocyte-spe…
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
2013
Author version made available in accordance with the publisher's policy.
Observations and snow model simulations of winter energy balance terms within and between different coniferous forests in Southern Boreal Finland
2015
Variation of canopy properties between different forest types is seldom taken into account in hydrological and climate models, and consideration of variation inside a forest is normally omitted. In this work, three data sets on near surface energy balance terms (incoming shortwave and longwave radiation; air and snow–soil interface temperatures) were collected in the southern boreal coniferous zone in Finland during three winters below different types of forest canopies. The aim was to evaluate the ability of a snow mass and energy balance model with a canopy module to reproduce the observed differences in below-canopy incoming radiations and snow–soil interface temperature. Clear differenc…
Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23
2021
Abstract Aims Our objective was to better understand the genetic bases of dilated cardiomyopathy (DCM), a leading cause of systolic heart failure. Methods and results We conducted the largest genome-wide association study performed so far in DCM, with 2719 cases and 4440 controls in the discovery population. We identified and replicated two new DCM-associated loci on chromosome 3p25.1 [lead single-nucleotide polymorphism (SNP) rs62232870, P = 8.7 × 10−11 and 7.7 × 10−4 in the discovery and replication steps, respectively] and chromosome 22q11.23 (lead SNP rs7284877, P = 3.3 × 10−8 and 1.4 × 10−3 in the discovery and replication steps, respectively), while confirming two previously identif…
RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets.
2019
Background MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. To discern further RISC functions, we analyzed the activities of two RISC proteins, AGO2 and GW182, in the MCF-7 human breast cancer cell line. Methods We performed three RIP-Chip experiments using either anti-AGO2 or anti-GW182 antibodies and compiled a data set made up of the miRNA and mRNA expression profiles of three samples for each experiment. Specifically, we analyzed the input sample, the immunoprecipita…
Traduzioni dal cinese in italiano di poesie
2018
Su richiesta dell'Editore della rivista "Zuopin", ho tradotto dal cinese all'italiano le poesie di 24 poeti lavoratori. L'elenco degli Autori e delle poesie tradotte è il seguente: Yang Ke: "Popolo", "Canton", "Attraversare" Zheng Xiaoqiong: "Officina", "Testimoniare", Hu Zhimin", "Yan Fen" Xie Xiangnan: "Camminare lungo la linea fra città e campagna", "Numeri", "Nella città di Xili", "Masticare canna da zucchero", "Respirare" Fang Zhou: "Ragazze che producono scarpe", "Una farfalla della zona industriale", "Il poeta nella stanza in affitto" Guo Jinniu: "Distratto in una fabbrica di mobili", " 'Il Capitale', attraverso aria, acqua e cibo, penetra nel corpo umano", "Via della magnolia Yulan"…
Observed changes in the life time and amplitude of the madden-julian oscillation associated with interannual ENSO sea surface temperature anomalies
2007
Abstract The Madden–Julian oscillation (MJO) is analyzed using the reanalysis zonal wind– and satellite outgoing longwave radiation–based indices of Wheeler and Hendon for the 1974–2005 period. The average lifetime of the MJO events varies with season (36 days for events whose central date occurs in December, and 48 days for events in September). The lifetime of the MJO in the equinoctial seasons (March–May and October–December) is also dependent on the state of El Niño–Southern Oscillation (ENSO). During October–December it is only 32 days under El Niño conditions, increasing to 48 days under La Niña conditions, with similar values in northern spring. This difference is due to faster eastw…
Time propagation of the Kadanoff–Baym equations for inhomogeneous systems
2009
We have developed a time propagation scheme for the Kadanoff-Baym equations for general inhomogeneous systems. These equations describe the time evolution of the nonequilibrium Green function for interacting many-body systems in the presence of time-dependent external fields. The external fields are treated nonperturbatively whereas the many-body interactions are incorporated perturbatively using Phi-derivable self-energy approximations that guarantee the satisfaction of the macroscopic conservation laws of the system. These approximations are discussed in detail for the time-dependent Hartree-Fock, the second Born and the GW approximation.
GW170817: Measurements of Neutron Star Radii and Equation of State
2018
On 17 August 2017, the LIGO and Virgo observatories made the first direct detection of gravitational waves from the coalescence of a neutron star binary system. The detection of this gravitational-wave signal, GW170817, offers a novel opportunity to directly probe the properties of matter at the extreme conditions found in the interior of these stars. The initial, minimal-assumption analysis of the LIGO and Virgo data placed constraints on the tidal effects of the coalescing bodies, which were then translated to constraints on neutron star radii. Here, we expand upon previous analyses by working under the hypothesis that both bodies were neutron stars that are described by the same equation…
Influence of the quadratic term in the alongwind stochastic response of SDOF structures
1996
A parametric study, regarding the influence of the quadratic pressure term, which is often neglected in the literature, on the stochastic alongwind response of a single-degree-of-freedom (SDOF) structure subjected to wind action, is presented. The results are reported in terms of percentages of difference in the evaluation of the response, by considering and neglecting the quadratic pressure term. The changing parameters considered are: the terrain drag coefficient, the structure height, the structure natural radian frequency, the structure damping coefficient and the wind reference mean velocity. The response stochastic analysis has been carried out in the time domain, by means of the mome…