Search results for "Genetic Structures"
showing 10 items of 2107 documents
Quantitative analysis of fatty acids on choline- and ethanolamine-phospholipids in human ocular and non-ocular tissues by liquid chromatography/tande…
2011
Quantitative analysis of fatty acids on choline- and ethanolamine-phospholipids in human ocular and non-ocular tissues by liquid chromatography/tandem mass spectrometry (LC-ESI-MS/MS). annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO)
Choroidal thickness in glaucomatous eyes measured by spectral domain optical coherence tomography
2011
Choroidal thickness in glaucomatous eyes measured by spectral domain optical coherence tomography. Annual meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO)
Ultrastructural changes in the outer retina and retinal pigment epithelium of the apob100,LDLR-/- mouse, a murine model of aging of the human retina
2011
Ultrastructural changes in the outer retina and retinal pigment epithelium of the apob100,LDLR-/- mouse, a murine model of aging of the human retina. annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO)
Time course of IOP elevation, electroretinographic changes and retinal ganglion cell loss in a rat model of glaucoma induced by laser
2007
International audience; Purpose: To evaluate the time course of intraocular pressure (IOP) elevation, electroretinographic changes and retinal ganglion cell (RGC) loss in a rat model of glaucoma induced by photocoagulation of the trabeculum and the episcleral and limbal veins. Methods: Male Sprague Dawley rats were used at 6 weeks of age. At least 3 of the episcleral veins, the trabeculum and the limbal veins were photocoagulated with a laser at 532nm (Quantel Medical, Vitra) in one eye of the animals. IOP and electroretinogram (ERG) were monitored every 2 weeks during 11 weeks after photocoagulation. Three months after laser photocoagulation, the RGC population was identified with a 5% Flu…
Food composition and structure, in-mouth breakdown, oral physiology and sensory perception: example of dairy products
2018
During eating, the first food transformations occur in the mouth and constitute preliminary steps of a series of reactions leading to digestion. Food breakdown occurring in the mouth contributes to the bolus formation and to the release of the stimuli responsible for the global sensory perception. However food breakdown not only depends on food composition and structure but also on human oral physiology, which could explain the high inter-individual differences observed in sensory perception and liking. After a general introduction, the presentation will focus on examples related to dairy products. Dairy products offer a great variability in terms of composition and structure and their liki…
A pro-diabetic diet triggers early functional and structural changes in the rat retina
2017
International audience; Purpose : Diabetic retinopathy (DR) is the leading cause of blindness in industrial countries before the age of 50 years. The early consequences of diabetes on the retina are nevertheless poorly known. We therefore aimed at characterizing the early effects of a high fructose and high fat diet on the function and structure of the rat retina. Methods : Male Brown Norway rats (6 weeks of age) were fed for 8 days (n=16), 4 weeks (n=16) and 12 weeks (n=8) with 60% fructose+10% lipid rich diet (HFHF), or a standard chow (n=8). At each time point, intraperitoneal insulin tolerance test (ITT-0.5 U/ml) and intraperitoneal glucose tolerance test (GTT-2g/kg body weight) were ca…
Plasmalogens in the pathogenesis of glaucomatous optic neuropathy
2011
Neuronal tissues such as the retina contain high amounts of plasmalogens. One of their particularities is to concentrate polyunsaturated fatty acids (PUFA) before releasing them specifically. Several data from our laboratory suggest that plasmalogens are involved in the pathophysiology of primary open angle glaucoma (POAG), the second leading cause of blindness worldwide. The different experiments were carried out on human patients with POAG as well as on rodent models of glaucoma. They concerned either the identification of specific alterations of plasmalogen metabolism, or the efficacy of PUFAs to prevent retinal damage. The results have shown a loss of several circulating plasmalogens in…
In-mouth mechanism leading to the perception of fat and its consequence on post-prandial lipid metabolism in humans. The particular role of saliva
2014
In humans, the in-mouth perception of dietary fat in food is a complex process involving many sensory modalities (texture, aroma, taste and trigeminal). During food oral processing, a bolus is formed in which saliva is significantly incorporated thus contributing significantly to the perception of fat. In particular, it has been shown that the levels of some salivary characteristics (lipolysis, lysozyme, flux, antioxidant status, level of carbonic anhydrase and proteins) are related to the sensitivity of the individual to triolein and oleic acid. Interestingly, the involvement of some of these salivary variables in the perceived intensity and preference towards model oil emulsions was also …
Typology of exogenous organic matters based on chemical and biochemical composition to predict potential nitrogen mineralization
2010
Our aim was to develop a typology predicting potential N availability of exogenous organic matters (EOMs) in soil based on their chemical characteristics. A database of 273 EOMs was constructed including analytical data of biochemical fractionation, organic C and N, and results of N mineralization during incubation of soil–EOM mixtures in controlled conditions. Multiple factor analysis and hierarchical classification were performed to gather EOMs with similar composition and N mineralization behavior. A typology was then defined using composition criteria to predict potential N mineralization. Six classes of EOM potential N mineralization in soil were defined, from high potential N minerali…
Cholesterol metabolism via cyp46a1 in glaucoma
2012
Cholesterol metabolism via cyp46a1 in glaucoma. International society for eye research (ISER) annual meeting