Search results for "Geriatric"
showing 10 items of 1602 documents
Decline in hospitalization rates for herpes zoster in Italy (2003-2018): reduction in the burden of disease or changing of hospitalization criteria?
2022
Background: Herpes Zoster (HZ) is a very demanding disease caused by the reactivation of latent Varicella Zoster Virus. The main aim of this study was to estimate the burden of the HZ hospitalizations in Italy from 2003 to 2018 evaluating temporal trends. Methods: Retrospective population-based study analyzing Hospital Discharge Records. Hospitalization records reporting the ICD-9 CM 053.X code in the principal diagnosis or in any of the five secondary diagnoses were considered as cases. Trends of hospitalization rates have been evaluated by Joinpoint analyses. Results: Overall, 99,036 patients were hospitalized with HZ in the 16-year period of the study, and 83,720 (84.5%) of these patient…
Role of physical activity in ameliorating neuropsychiatric symptoms in Alzheimer disease: A narrative review
2019
Objective: Neuropsychiatric symptoms (NPs) affect almost all patients with Alzheimer disease (AD). Because of the complications associated with the pharmacological treatment, nonpharmacological treatment (such as physical activity) can be considered as an additional complementary treatment option for NPs. The aim of this review is to evaluate the impact of physical activity on NPs in patients with AD. Methods: We searched Pubmed and Google Scholar for potential eligible articles until March 1, 2018. Results: Although there are contradictory results showing the impact of physical exercise on NPs, most of them reported that it had a significant effect on depression and sleep disturbances in p…
Impact of the Relationship of Stress and the Immune System in the Appearance of Alzheimer’s Disease
2016
The understanding of how the immune system works, as well as its relationship with the stress level, seems to be important at the start of the Alzheimer’s disease (AD). To analyze this, immunoglobulin A (IgA) and cortisol in saliva were measured using ELISA in patients with mild AD and healthy volunteers, and the production of both biomarkers was compared and correlated. In participants without AD, IgA was higher when cortisol was lower, and the opposite happened in participants with AD, with the quantification in saliva being a suitable method to determine it. Sin financiación 1.635 SJR (2017) Q1, 12/108 Geriatrics and Gerontology, 239/2885 Medicine (miscellaneous), 64/529 Psychiatry and M…
Inflammation, genetic background and longevity
2010
Ageing is an inexorable intrinsic process that affects all cells, tissues, organs and individuals. Due to a diminished homeostasis and increased organism frailty, ageing causes a reduction of the response to environmental stimuli and, in general, is associated to an increased predisposition to illness and death. Actually, it is characterized by a state of reduced ability to maintain health and general homeodynamics of the organism. A large part of the ageing phenotype is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status of ageing, "inflamm-ageing". It is strictly linked to immunosenescence, and on th…
Pragmatic Diabetes Management in Nursing Homes: Individual Care Plan
2013
Although the management of diabetes as a simple entity has been extensively developed, there is a dearth of evidence in elderly, frail patients with multiple comorbidities and polymedication. This population represents a large proportion of the residents of nursing homes (NHs). As a multidisciplinary group of French experts (geriatricians, endocrinologists, diabetologists, and general practitioners) with practical experience in this area, which is growing in magnitude throughout the world, we convened to compile pragmatic, simple advice on the management of elderly, frail diabetic patients. Given demands on NH personnel (manager, medical coordinator, nurses, and, at the front line of care p…
A New Tool for the Analysis of the Effect of Intracerebrally Injected Anti-Amyloid-β Compounds
2021
Background: A wide range of techniques has been developed over the past decades to characterize amyloid-β (Aβ) pathology in mice. Until now, no method has been established to quantify spatial changes in Aβ plaque deposition due to targeted delivery of substances using ALZET® pumps. Objective: Development of a methodology to quantify the local distribution of Aβ plaques after intracerebral infusion of compounds. Methods: We have developed a toolbox to quantify Aβ plaques in relation to intracerebral injection channels using Zeiss AxioVision® and Microsoft Excel® software. For the proof of concept, intracerebral stereotactic surgery was performed in 50-day-old APP-transgenic mice injected wit…
The Silent Voice of Women Teachers in Latin America. Educating from Invisibility
2020
Resumen Este artículo de investigación presenta el proyecto Mujeres Maestras es un homenaje a las docentes desde la perspectiva de la investigación basada en las artes. Parte de una narrativa personal ambientada en la docencia universitaria como formador de docentes en artes desde hace tres décadas. El proyecto ha evolucionado como acción artística, un work in progress todavía vigente desde 2005. Nuestro objetivo principal consiste en acercarnos a las identidades de las maestras realizando exposiciones en museos, muestras que incorporan tres miradas: las obras del propio autor, los dibujos del alumnado, y los videos de entrevistas a las educadoras. Entre los objetivos secundarios destacamos…
Akzeptanz und Nutzung öffentlicher Automaten durch Ältere: Ergebnisse einer europÄischen Untersuchung
2000
Die Autoren dieses Beitrags stellen Befunde uber altere Manner und Frauen als Nutzer von Fahrkartenautomaten, Bankautomaten und Kartentelefonen vor. Basis der Analysen bilden Daten, die im Rahmen des internationalen Kooperationsprojektes „Keeping the Elderly Mobile“ in vier europaischen Stadten erhoben wurden. Die Untersuchungen fanden 1995 in Mannheim (Westdeutschland) mit 404, in Chemnitz (Ostdeutschland) mit 400, in Ancona (Italien) mit 600 und in Jyvaskyla (Finnland) mit 618 in Privathaushalten lebenden Befragten statt, die aus den jeweiligen Einwohnermeldedregistern zufallig ausgewahlt wurden. Die nach Geschlecht und Alter disproportional geschichtete Stichprobe setzte sich zu gleichen…
Validity and Reliability of a Single Question for Leisure-Time Physical Activity Assessment in Middle-Aged Women.
2020
Purpose: To investigate the validity and test–retest reliability of a single seven-level scale physical activity assessment question (SR-PA L7) and its three-level categorization (SR-PA C3). Methods: The associations of SR-PA L7 and C3 with accelerometer-measured leisure-time physical activity (ACC-LTPA) and with the results of four different physical performance tests (6-min walk [n = 733], knee extension [n = 695], vertical jump [n = 731], and grip force [n = 780]) were investigated among women aged 47–55 years participating in the Estrogenic Regulation of Muscle Apoptosis study (n = 795). The reliability was studied using Spearman correlations with 4-month test–retest period (n = 152). R…
DCTN1 mutation analysis in Italian patients with PSP, MSA, and DLB
2020
Abstract DCTN1 encodes the largest subunit of dynactin complex essential in the retrograde axonal transport and cytoplasmic transport of vesicles; mutations in DCTN1 have been reported predominantly in individuals with Perry syndrome and, recently, in patients with progressive supranuclear palsy. Our genetic screening of DCTN1 in 79 patients with progressive supranuclear palsy, 100 patients with multiple system atrophy, and 28 patients with dementia with Lewy bodies from Italy revealed only synonymous and intronic variants, suggesting that DCTN1 mutations do not have a key role in the development of atypical parkinsonism in the Italian population.