Search results for "Grade"
showing 10 items of 695 documents
Ultrascale+ for the new ATLAS calorimeter trigger board dedicated to jet identification
2018
To cope with the expected increase in luminosity at the Large Hadron Collider in 2021, the ATLAS collaboration is planning a major detector upgrade to be installed during Long Shutdown 2. As a part of this, the Level 1 trigger, based on calorimeter data, will be upgraded to exploit the fine granularity readout using a new system of Feature EXtractors (FEXs), which each reconstruct different physics objects for the trigger selection. The Jet FEX (jFEX) is one of three FEXs and has been conceived to identify small/large area jets, large area tau leptons, missing transverse energy and the total sum of the transverse energy. The use of the latest generation Xilinx Field Programmable Gate Array …
Upgrade of the ATLAS Central Trigger for LHC Run-2
2015
The increased energy and luminosity of the LHC in the run-2 data taking period requires a more selective trigger menu in order to satisfy the physics goals of ATLAS. Therefore the electronics of the central trigger system is upgraded to allow for a larger variety and more sophisticated trigger criteria. In addition, the software controlling the central trigger processor (CTP) has been redesigned to allow the CTP to accommodate three freely configurable and separately operating sets of sub detectors, each independently using the almost full functionality of the trigger hardware. This new approach and its operational advantages are discussed as well as the hardware upgrades.
Melt development of biphasic functionally graded scaffold
2016
Interface tissue engineering requires scaffolds that temporary replace the mechanical function of transition regions between two adjacent tissues. The presence of multi-phasic bio-structures that gradually change are typical features of interface tissues such as ligament-to-bone, tendon-to-bone and cartilage-to-bone. In this work, bi-layered scaffolds (BLS) composed by PLA with pores in the range of 90-110 µm and PCL with pores ranging from 5 to 40 µm were prepared by combining melt mixing, compression molding and particulate leaching. The principal advantages of this method lay in the absence of organic solvent during the preparation and in the easy control and high predictability of poros…
Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters
2021
Melatonin, the hormone of circadian rhythm regulation, is involved in the modulation of mitochondrial activity through its antioxidant and anti-inflammatory properties. Alteration of circadian rhythms such as sleep is related to obesity and metabolic pathogenesis in adulthood, but studies during childhood are scarce. The present study investigated the association of melatonin with metabolic and inflammatory markers in children with (n = 113) and without obesity (n = 117). Melatonin was measured in saliva four and two hours before bedtime, and after one hour of sleep. Cardiometabolic factors, high sensitivity C-reactive protein, immune markers (monocyte chemoattractant protein-1, plasminogen…
eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1.
2017
The actin cytoskeleton coordinates the organization of signaling microclusters at the immune synapse (IS); however, the mechanisms involved remain poorly understood. We show here that nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) controls the coalescence of protein kinase C-¿ (PKC-¿) at the central supramolecular activation cluster (c-SMAC) of the IS. eNOS translocated with the Golgi to the IS and partially colocalized with F-actin around the c-SMAC. This resulted in reduced actin polymerization and centripetal retrograde flow of ß-actin and PKC-¿ from the lamellipodium-like distal (d)-SMAC, promoting PKC-¿ activation. Furthermore, eNOS-derived NO S-nitrosylated ß-…
Combined aerobic and resistance training decreases inflammation markers in healthy men
2018
Our primary aim was to study the effects of 24 weeks of combined aerobic and resistance training performed on the same day or on different days on inflammation markers. Physically active, healthy young men were randomly divided into three groups that performed: aerobic and resistance training consecutively in the same training session (SS) 2-3 days wk−1 or on alternating days (AD) 4-6 days wk−1 as well as control (C). The total training volume was matched in the training groups. The control group was asked to maintain their habitual physical activity and exercise level. Maximal leg press strength (1RM) and peak oxygen uptake (VO2peak) were measured. Abdominal fat mass was estimated with dua…
Neural correlates of morphological processing and its development from pre-school to the first grade in children with and without familial risk for d…
2022
Previous studies have shown that the development of morphological awareness and reading skills are interlinked. However, most have focused on phonological awareness as a risk factor for dyslexia, although there is considerable diversity in the underlying causes of this reading difficulty. Specifically, the relationship between phonology, derivational morphology, and dyslexia in the Finnish language remains unclear. In the present study, we used magnetoencephalography (MEG) to measure the brain responses to correctly and incorrectly derived Finnish nouns in 34 first grade Finnish children (21 typically developing and 13 with familial risk for dyslexia). In addition, we compared longitudinall…
The expression mechanism of the residual LTP in the CA1 region of BDNF k.o. mice is insensitive to NO synthase inhibition
2011
Abstract BDNF and nitric oxide signaling both contribute to long-term potentiation (LTP) at glutamatergic synapses, but to date, few studies analyzed the interaction of both signaling cascades in the same synaptic pathway. Here we addressed the question whether the residual LTP in the CA1 region of hippocampal slices from heterozygous BDNF knockout mice (BDNF +/− ) is dependent on nitric oxide (NO) signaling. Extracellular recording of synaptic field potentials elicited by presynaptic Schaffer collateral stimulation was performed in the CA1 region of hippocampal slices of 4- to 6-week-old mice, and LTP was induced by a theta burst stimulation protocol. Application of the nitric oxide inhibi…
Positive Teacher Affect and Maternal Support Facilitate Adjustment After the Transition to First Grade
2016
This longitudinal study, conducted among a sample of Finnish primary-school children, examined the proposition that a single high-quality relationship (either with a teacher or a parent) can buffer against adjustment problems. Teachers rated the externalizing problems and prosocial behaviors of 378 children in Grade 1 and again in Grade 2. Relationship measures gathered in Grade 1 included teacher reports of positive affect for the child and mother reports of support for the child. The results supported our proposition by showing that for child adjustment after the transition to primary school it was critical to have at least one high-quality relationship either with a teacher or a parent. …
School grades as predictors of self-esteem and changes in internalizing problems: A longitudinal study from fourth through seventh grade
2020
This longitudinal study of 562 students (from ages 10 to 13) investigated whether developmental changes in internalizing problems (emotional and peer problems) can be predicted by school grades in mathematics and language arts and whether these predictive relations are mediated by students' self-esteem. The data comprised of teacher-rated internalizing problems, grades in math and language arts, and student self-ratings of self-esteem. The latent change score modeling indicated that math grades positively predicted self-esteem. Furthermore, lower self-esteem was related to an increase in internalizing and emotional problems in the total sample, and to an increase in peer problems in boys. T…