Search results for "Gram"
showing 10 items of 9069 documents
Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells.
2011
SUMMARYAlthough many cancer cells are primed for apoptosis, they usually develop resistance to cell death at multiple levels. Permeabilization of the outer mitochondrial membrane, which is mediated by proapoptotic Bcl-2 family members like Bax, is considered as a point-of-no-return for initiating apoptotic cell death. This crucial role has placed Bcl-2 family proteins as recurrent targets for anticancer drug development. Here, we propose and demonstrate a new concept based on using minimal active version of Bax to induce cell death independently of endogenous Bcl-2 proteins. We show that membrane-active segments of Bax can directly induce the release of mitochondria-residing apoptogenic fac…
Generalized hypergeometric functions and the evaluation of scalar one-loop integrals in Feynman diagrams
2000
Present and future high-precision tests of the Standard Model and beyond for the fundamental constituents and interactions in Nature are demanding complex perturbative calculations involving multi-leg and multi-loop Feynman diagrams. Currently, large effort is devoted to the search for closed expressions of loop integrals, written whenever possible in terms of known - often hypergeometric-type - functions. In this work, the scalar three-point function is re-evaluated by means of generalized hypergeometric functions of two variables. Finally, use is made of the connection between such Appell functions and dilogarithms coming from a previous investigation, to recover well-known results.
Scenario optimization asset and liability modelling for individual investors
2006
We develop a scenario optimization model for asset and liability management of individual investors. The individual has a given level of initial wealth and a target goal to be reached within some time horizon. The individual must determine an asset allocation strategy so that the portfolio growth rate will be sufficient to reach the target. A scenario optimization model is formulated which maximizes the upside potential of the portfolio, with limits on the downside risk. Both upside and downside are measured vis- `a-vis the goal. The stochastic behavior of asset returns is captured through bootstrap simulation, and the simulation is embedded in the model to determine the optimal portfolio. …
On the number of solutions of a Duffing equation
1991
The exact number of solutions of a Duffing equation with small forcing term and homogeneous Neumann boundary conditions is given. Several bifurcation diagrams are shown.
Sampling methods for low-frequency electromagnetic imaging
2007
For the detection of hidden objects by low-frequency electromagnetic imaging the linear sampling method works remarkably well despite the fact that the rigorous mathematical justification is still incomplete. In this work, we give an explanation for this good performance by showing that in the low-frequency limit the measurement operator fulfils the assumptions for the fully justified variant of the linear sampling method, the so-called factorization method. We also show how the method has to be modified in the physically relevant case of electromagnetic imaging with divergence-free currents. We present numerical results to illustrate our findings, and to show that similar performance can b…
The factorization method for real elliptic problems
2006
The Factorization Method localizes inclusions inside a body from mea- surements on its surface. Without a priori knowing the physical parameters inside the inclusions, the points belonging to them can be characterized using the range of an auxiliary operator. The method relies on a range characterization that relates the range of the auxiliary operator to the measurements and is only known for very particular applications. In this work we develop a general framework for the method by considering sym- metric and coercive operators between abstract Hilbert spaces. We show that the important range characterization holds if the difference between the inclusions and the background medium satisfi…
Noroviral P-Particles as an In Vitro Model to Assess the Interactions of Noroviruses with Probiotics
2014
Noroviruses (NoVs) are the main etiologic agents of acute epidemic gastroenteritis and probiotic bacteria have been reported to exert a positive effect on viral diarrhea. The protruding (P) domain from NoVs VP1 capsid protein has the ability to assemble into the so-called P-particles, which retain the binding ability to host receptors. We purified the P-domains from NoVs genotypes GI.1 and GII.4 as 6X(His)-tagged proteins and determined that, similar to native domains, they were structured into P-particles that were functional in the recognition of the specific glycoconjugated receptors, as established by surface plasmon resonance experiments. We showed that several lactic acid bacteria (pr…
A Hardware and Secure Pseudorandom Generator for Constrained Devices
2018
Hardware security for an Internet of Things or cyber physical system drives the need for ubiquitous cryptography to different sensing infrastructures in these fields. In particular, generating strong cryptographic keys on such resource-constrained device depends on a lightweight and cryptographically secure random number generator. In this research work, we have introduced a new hardware chaos-based pseudorandom number generator, which is mainly based on the deletion of an Hamilton cycle within the $N$ -cube (or on the vectorial negation), plus one single permutation. We have rigorously proven the chaotic behavior and cryptographically secure property of the whole proposal: the mid-term eff…
Étude sur les réformes curriculaires par l'approche par compétences en Afrique
2009
Cette étude vise trois objectifs : réaliser un état des lieux des processus de réformes curriculaires en éducation de base en Afrique pour identifier les problèmes rencontrés, les résultats positifs et les "bonnes pratiques", aider les responsables des systèmes éducatifs à prendre des mesures pertinentes et accompagner les réformes et enfin aider les bailleurs de fonds à mieux comprendre les effets de leur aide et à mieux cibler les projets de réforme en termes de coût et d'efficacité à tous les niveaux des systèmes éducatifs impliqués.
Hop: Histogram of patterns for human action representation
2017
This paper presents a novel method for representing actions in terms of multinomial distributions of frequent sequential patterns of different length. Frequent sequential patterns are series of data descriptors that occur many times in the data. This paper proposes to learn a codebook of frequent sequential patterns by means of an apriori-like algorithm, and to represent an action with a Bag-of-Frequent-Sequential-Patterns approach. Preliminary experiments of the proposed method have been conducted for action classification on skeletal data. The method achieves state-of-the-art accuracy value in cross-subject validation.