Search results for "Granuloma"

Annular Elastolytic Giant Cell Granuloma

2020

THU0045 IL-25/IL-17RB AXIS IS ACTIVATED AND ASSOCIATED WITH ILC2 EXPANSION IN GRANULOMATOSIS WITH POLYANGIITIS (GPA)

2019

Background: Pathogenesis of Granulomatosis with polyangiitis (GPA) is still unknown. However, it has been observed a skewing of circulating CD4+ T cells toward the Th17 and Th2 phenotype. The pro-inflammatory cytokine interleukin 25 (IL-25) is a member of IL-17 cytokine family associated to the Th2 immune phenotype. Through the receptor IL17RB, IL-25 further sustains the Th2-type immune response and elicits the expansion of the type 2 innate lymphoid cells (ILC2) and M2 macrophages. A pathogenic role of the innate lymphoid cells in GPA has been recently demonstrated; however, the relevance of IL-25 in this condition remains unexplored. Objectives: Aim of the study was to evaluate the expres…

Classification of Intracranial Tumors

1981

L. Bruns (1914) stated in Krause’s “General Neurosurgery” that brain tumors included all neoplasms growing within the cranial cavity and that these might be divided into three groups: (1) genuine tumors, (2) granulomatous lesions, and (3) parasites. Current use of the term “brain tumor” is more precise and limited to the first of L. Bruns’ categories. Even so, brain tumors represent a large and inhomoge-neous group. The comparison and evaluation of such a diverse set of observations is only possible after making a systematic classification of pertinent data.

Granulomas en dermatopatología: principales entidades. Parte II

2021

Part 2 of this series on granulomatous diseases focuses on skin biopsy findings. Whereas the first part treated noninfectious conditions (metabolic disorders and tumors, among other conditions), this part mainly deals with various types of infectious disease along with other conditions seen fairly often by clinical dermatologists.

Orofacial granulomatosis: a rare case report with review of literature

2010

The term orofacial granulomatosis (OFG) is a descriptive term used for granulomatous disorders affecting the face and oral cavity, which can occur for a variety of reasons resulting in significant morbidity. It is characterised by persistent swelling that may involve one or both the lips and /or recurrent ulcers and a variety of other orofacial features. Medical history is very important in the diagnosis of OFG as medical condition like Crohn’s disease can also present an extra intestinal manifestation of OFG. Exclusion of other entities like sarcoidosis, mycobacterial infections, foreign body reactions and biopsy helps to establish a correct diagnosis. Herein we report a case of OFG in a 5…

Pyogenic granuloma in relation to dental implants: Clinical and histopathological findings

2015

Background: The occurrence of pyogenic granuloma in association to dental implants is rare and only five cases have been reported in the literature. Material and Methods: Patients charts were analyzed to select patients who had been diagnosed for pyogenic granuloma and its association with dental implants had been evaluated. The clinical status of the dental implants and the prosthesis had also been assessed. Results: Clinical and histopathological diagnosis of pyogenic granuloma had been reached for soft mass growth in association with dental implants in 10 patients. Histological analysis of all samples was performed to obtain a firm diagnosis of finding against pyogenic granuloma lesions.…

Ar ANCA asociēto glomerulonefrītu terapijas efektivitātes izvērtējums Paula Stradiņa Klīniskās universitātes slimnīcas Nefroloģijas centrā

2018

Ar anti-neitrofilu citoplazmas antivielām asociētie vaskulīti ir reta, autoimūna slimība, ko raksturo iekaisums un nekroze maza un vidēja kalibra asinsvados. Izšķir trīs slimības fenotipus: granulomatoze ar poliangiītu (GPA), mikroskopiskais poliangiīts (MPA) un eozinofilā granulomatoze ar poliangiītu (EGPA). Aptuveni 80 % pacientu ar GPA un 90 % pacientu ar MPA slimības gaitā attīstās nieru bojājums – ar ANCA asociēts glomerulonefrīts (AAGN). Kopš imūnsupresīvās terapijas ieviešanas, remisiju iespējams inducēt līdz pat 90 % pacientu, tomēr joprojām pastāv problēmas AAV ārstēšanas taktikā. Vismaz 20 % pacientu ir rezistenti pret sākotnējo terapiju un vismaz 50 % slimnieku 5 gadu laikā attīs…

Surgical repair of acute Achilles tendon rupture with an end-to-end tendon suture and tendon flap.

2015

Abstract Background Achilles tendon ruptures are becoming more common. Complications after open or minimally invasive surgery are: recurrent rupture (2–8%), wound breakdown, deep infections, granuloma, and fistulas. The authors expose their experience with a personal technique. Materials In 8 patients with acute rupture of Achilles tendon the surgery was performed at least 25 days after trauma. Clinical exam and MR demonstrated in all case a total lesion of tendon. After a posterolateral skin incision the tendon stumps were debrided and suture in end-to-end fashion. A tendon flap was harvested from the proximal part of the tendon, in order to protect and reinforce the suture itself. A plast…

Granuloma anulare disseminatum als seltene Nebenwirkung von Allopurinol

1995

During long-term therapy of hyperuricaemia with allopurinol (300 mg/d) two patients developed generalized granuloma annulare. The diagnoses were confirmed by histology; concomitant diseases, especially diabetes mellitus, were not detectable. Following discontinuation of allopurinol therapy, cutaneous granulomas healed without relapse. Hyperuricaemia could be controlled by low-purine diet and medication avoiding allopurinol. The clinical history of our two patients suggested a causal connection between allopurinol therapy and generalized granuloma annulare. For this reason we rate the development of this disease in both cases as a rare but significant side effect of allopurinol. This should …

Granuloma periférico de células gigantes. A propósito de 5 casos y revisión de la literatura

2005

El granuloma periférico de células gigantes (GPCG) es una lesión reactiva benigna relativamente frecuente de la cavidad bucal. Se origina a partir del periostio o de la membrana periodontal tras una irritación o un traumatismo crónico que actúa localmente. Se manifiesta en forma de nódulo de color rojo-púrpura, situado en la encía o en el reborde alveolar edéntulo, preferentemente en la mandíbula. Aparece a cualquier edad, con una mayor incidencia entre la quinta y sexta décadas de la vida, con una ligera predilección por el sexo femenino. Es una lesión de las partes blandas que muy rara vez implica el hueso subyacente, aunque puede causarle una erosión superficial. Se han revisado cinco ca…