Search results for "Group A"
showing 10 items of 274 documents
Results from a phase III trial (GRID) evaluating regorafenib (REG) in metastatic gastrointestinal stromal tumour (GIST): Subgroup analysis of outcome…
2013
10551 Background: REG, an oral receptor kinase inhibitor with activity against KIT, PDGFR, VEGFR, FGFRs, and other oncologic targets, demonstrated significant improvement in progression-free survival (PFS) over placebo (PL) in a phase III study (GRID) of patients (pts) with advanced GIST following failure of at least imatinib (IM) and sunitinib (SU). To understand the impact of pts’ baseline characteristics on outcome, we performed an exploratory analysis of REG effects across pt subgroups based on sex, age, and mitotic index of primary GIST tissue, as well as duration and number of lines of previous therapies. Methods: Adult pts with metastatic GIST (n=199) progressing after at least IM a…
Clinical and Molecular-Based Approach in the Evaluation of Hepatocellular Carcinoma Recurrence after Radical Liver Resection
2021
Background: Hepatic resection remains the treatment of choice for patients with early-stage HCC with preserved liver function. Unfortunately, however, the majority of patients develop tumor recurrence. While several clinical factors were found to be associated with tumor recurrence, HCC pathogenesis is a complex process of accumulation of somatic genomic alterations, which leads to a huge molecular heterogeneity that has not been completely understood. The aim of this study is to complement potentially predictive clinical and pathological factors with next-generation sequencing genomic profiling and loss of heterozygosity analysis. Methods: 124 HCC patients, who underwent a primary hepatic …
Immunonutritive Scoring in Patients With Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization: Prognostic Nutritional Index or Control…
2021
ObjectivesThe Prognostic Nutritional Index (PNI) and Controlling Nutritional Status (CONUT) score are immunonutritive scoring systems with proven predictive ability in various cancer entities, including hepatocellular carcinoma (HCC). We performed the first evaluation of the CONUT score for patients undergoing transarterial chemoembolization (TACE) and compared CONUT and PNI in the ability to predict median overall survival (OS).MethodsBetween 2010 and 2020, we retrospectively identified 237 treatment-naïve patients with HCC who underwent initial TACE at our institution. Both scores include the albumin level and total lymphocyte count. The CONUT additionally includes the cholesterol level. …
Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness
2021
Objective Recently, increasing epidemiological evidence has shown that there is a correlation between serum uric acid level (SUA) and carotid intima-media thickness (CIMT). This paper explored the relationship between them through meta-analysis. Methods PubMed, Cochrane Library, EMBASE, Web of Science and Google Scholar were searched to obtain literature. The keywords used to retrieve the literature were carotid intima thickness, intima-media thickness, carotid atherosclerosis, carotid stenosis, carotid artery, uric acid, blood uric acid, and hyperuricaemia. The retrieval time was from the establishment of the database through July 2020. Stata15.0 and RevMan5.3 software were used for stati…
Existence and Regularity for a Class of Nonlinear Hyperbolic Boundary Value Problems
2002
AbstractThe regularity of the solution of the telegraph system with nonlinear monotone boundary conditions is investigated by two methods. The first one is based on D'Alembert-type representation formulae for the solution. In the second method the telegraph system is reduced to a linear Cauchy problem with a locally Lipschitzian functional perturbation; then regularity results are established by appealing to the theory of linear semigroups.
Nachweis der Faktoren Gm (1,2,4,5,21) und In V(1) in menschlichen Sekreten: Speichel, Schwei�, Nasensekret und Sperma
1977
Im Sperma sind bei genugend Substrat Gm- und InV-Faktoren nachweisbar. An Uberlagerungen durch Nasen- oder Scheidensekret mus gedacht werden. Dagegen wirkt sich Schweis als Verunreinigung nicht storend aus. Im Speichel konnen keine Gm-, wohl aber InV-Merkmale festgestellt werden. Die Gummierung der Briefmarken reagiert unspezifisch mit InV-Antiseren und kommt daher als Fehlerquelle in Betracht. Der Beweiswert von Gm- und InV-Befunden bei Spurenuntersuchungen ergibt sich aus den Phanotyp-Frequenzen, die im Serum von 400 nichtverwandten Personen festgestellt wurden.
Unitary units and skew elements in group algebras
2003
Let FG be the group algebra of a group G over a field F and let * denote the canonical involution of FG induced by the map g→g −1 ,gG. Let Un(FG)={uFG|uu * =1} be the group of unitary units of FG. In case char F=0, we classify the torsion groups G for which Un(FG) satisfies a group identity not vanishing on 2-elements. Along the way we actually prove that, in characteristic 0, the unitary group Un(FG) does not contain a free group of rank 2 if FG − , the Lie algebra of skew elements of FG, is Lie nilpotent. Motivated by this connection we characterize most groups G for which FG − is Lie nilpotent and char F≠2.
Central Units, Class Sums and Characters of the Symmetric Group
2010
In the search for central units of a group algebra, we look at the class sums of the group algebra of the symmetric group S n in characteristic zero, and we show that they are units in very special instances.
Séparation des orbites coadjointes d'un groupe exponentiel par leur enveloppe convexe
2008
Resume Revenant sur la question de la separation des representations unitaires irreductibles d'un groupe de Lie exponentiel G par leur application moment, nous presentons ici une nouvelle solution : au lieu de prolonger l'application moment a l'algebre enveloppante de G , nous proposons de definir une application (non lineaire) Φ de g ∗ dans le dual g + ∗ de l'algebre de Lie d'un groupe resoluble G + , de prolonger les representations de G a G + de telle facon que les orbites coadjointes correspondantes de G + soient caracterisees par l'adherence de leur enveloppe convexe. Ceci nous permet de separer les representations irreductibles de G .
Central idempotents and units in rational group algebras of alternating groups
1998
Let ℚAn be the group algebra of the alternating group over the rationals. By exploiting the theory of Young tableaux, we give an explicit description of the minimal central idempotents of ℚAn. As an application we construct finitely many generators for a subgroup of finite index in the centre of the group of units of ℚAn.