Search results for "H.P.M."
showing 10 items of 738 documents
NMR structure of a non-conjugatable, ADP-ribosylation associated, ubiquitin-like domain from Tetrahymena thermophila polyubiquitin locus.
2019
Abstract Background Ubiquitin-like domains (UbLs), in addition to being post-translationally conjugated to the target through the E1-E2-E3 enzymatic cascade, can be translated as a part of the protein they ought to regulate. As integral UbLs coexist with the rest of the protein, their structural properties can differ from canonical ubiquitin, depending on the protein context and how they interact with it. In this work, we investigate T.th-ubl5, a UbL present in a polyubiquitin locus of Tetrahymena thermophila, which is integral to an ADP-ribosyl transferase protein. Only one other co-occurrence of these two domains within the same protein has been reported. Methods NMR, multiple sequence al…
‘Gente Borgia’. Un nuevo ejemplo del mecenazgo de los Borja: Primeras inscripciones humanísticas en Valencia
2019
Resumen: Escritura y heráldica se convierten en un lenguaje fundamental al servicio institucional y personal de los Borja, que desde Italia llegará también a su ciudad de origen y a sus señoríos. En Xàtiva y Gandía respectivamente se conservan las primeras inscripciones humanísticas que podemos ubicar en territorio valenciano. En ambos casos se trata de piezas vinculadas a la familia Borja y las dos se encuentran en el ámbito de las colegiatas de estas dos ciudades: en la capilla dedicada a Nuestra Señora de las Fiebres, advocación romana, cuya construcción mandó llevar a cabo en 1497 Francesc de Borja, tesorero pontificio, obispo de Teano, más tarde arzobispo de Cosenza y cardenal nombrado…
Enantioseparations with polysaccharide-based chiral stationary phases in HPLC. Application to the enantioselective evaluation of the biodegradability…
2023
The chiral nature of living systems has obvious implications for the biologically active compounds that interact with them. At the molecular level, chirality represents an intrinsic property of the essential building blocks of life, such as amino acids and sugars, and therefore, of peptides, proteins, enzymes, carbohydrates, nucleosides and a number of alkaloids and hormones. As a consequence, processes mediated by biological systems are stereochemistry-sensitive, and a pair of enantiomers can have different effects on living organisms. The scientific community has been studying the implications of chirality for life for more than a century. Today, it is still a topic of active research and…
Microleakage and shear bond strength of orthodontc brackets bonded to hypomineralized enamel following different surface preparations
2014
Objectives: This study investigated the effects of several conditioning methods on shear bond strength (SBS) and microleakage of orthodontic brackets bonded to demineralized enamel. Study Design: One hundred premolars were selected and immersed in a cariogenic solution for 12 weeks. The teeth were randomly assigned into 5 groups. In groups 1 and 2, the teeth underwent acid etching for 30 and 120 seconds, respectively. In group 3, a combination of laser and acid etching was employed. A self-etch primer (SEP) was applied in group 4 and in group 5, the teeth were exposed to acidulated phosphate fluoride (APF) for 4 minutes before etching. After bracket bonding, the teeth were immersed in methy…
Strategy and Practice for Sustainability in Businesses in the Middle East and North Africa in a Global Perspective
2022
A business may adopt a strategy for sustainability and may implement its strategy in its practice. Our question is, how are strategy and practice coupled and shaped by entrepreneurs and businesses embedded in national eco-systems in the Middle East and North Africa and around the world? Businesses were randomly sampled and surveyed in 2021, and national conditions were assessed by experts in ten countries in the Middle East and North Africa and in Spain and other countries around the world, as part of the Global Entrepreneurship Monitor. Strategy and practice are found to have a loose coupling but are tighter in the Middle East and North Africa than in Spain. Strategy is promoted by support…
A new communication approach for customer relationship management in the hotel industry
2014
“Visas uzņēmējdarbības pamatā ir attiecības. Uzņēmumam tikai tās saviem klientiem jāpadara uztveramas un jēgpilnas - ar nosacījumu, ka klienti to vēlas” (Grönroos 2007, 24 lpp.). Uzņēmuma spēja palielināt apgrozījumu, izmantojot efektīvu vadību attiecībās ar klientiem ir ļoti svarīga, lai pārvarētu ekonomisko nenoteiktību visā pasaulē. Jaunās digitālo mediju īpašības kopā ar milzīgu alternatīvo paņēmienu klāstu saziņai ar klientiem ir radījušas vadītājiem un akadēmiķiem gan iespējas, gan problēmas (Winer, 2009, 116. lpp.). Lai veiksmīgi realizētu klientu attiecību vadību, ļoti konkurētspējīgu tirgu, pieredzējušu un prasīgu klientu un pakalpojumu nozares specifikas dēļ viesnīcu uzņēmumiem ne…
Klientu attiecību pārvaldības sistēmu ieviešana MVU
2019
Pastāvot intensīvai konkurencei un ekonomiskai liberalizācijai, veicinot individuālas iniciatīvas un privāto sektoru, kā arī cenu liberalizācija kā svarīgs un papildinošs globalizācijas apstākļi un saskaņā ar jauniem datiem, mārketinga pieeju piemērošana ir neizbēgama bez efektīvas mārketinga. organizācijas var tikt pakļautas lieliem zaudējumiem, kas varētu izraisīt bankrotu un izstāšanos no tirgus. Vairāku desmitgažu laikā daudzi mārketinga jēdzieni un termini ir uzticējuši to kā galveno elementu organizāciju panākumiem un stratēģijām. Šie termini ir pazīstami tādiem mārketinga profesionāļiem kā klientu apkalpošana, klientu attiecības, lojalitātes klienti un, visbeidzot, klientu attiecību…
Development of Entrepreneurship Manager’s Professional Competence in Latvia
2013
Elektroniskā versija nesatur pielikumus
Mārketinga specifika sociālajā uzņēmējdarbībā Latvijā: patērētāju vērtību segmenti.
2019
Maģistra darba “Mārketinga specifika sociālajā uzņēmējdarbībā Latvijā: patērētāju vērtību segmenti” mērķis ir identificēt sociālo uzņēmumu produktu / pakalpojumu patērētāju vērtību segmentus un iegūt to raksturojumu, lai izstrādātu praktiskus priekšlikumus Latvijas sociālajiem uzņēmumiem to mārketinga efektivitātes palielināšanai. Lai sasniegtu mērķi, darba autore izvirza četras hipotēzes un sešus pētījuma uzdevumus. Pētījuma rezultātā darba autore iegūst detalizētus trīs lielāko Latvijas sociālo uzņēmumu produktu / pakalpojumu patērētāju vērtību segmentu profilus un, balstoties uz pētījumos iegūto datu analīzes rezultātiem un to interpretāciju, sniedz priekšlikumus Latvijas sociālajiem uzņ…
Fostering brand engagement and value-laden trusted B2B relationships through digital content marketing
2019
Purpose The purpose of this paper is to explore how digital content marketing (DCM) users can be engaged with business-to-business (B2B) brands and determine how such engagement leads to value-laden trusted brand relationships. Design/methodology/approach Through an online survey, data were collected from the email marketing list of a large B2B brand, and the hypothesised research model was analysed using covariance-based structural equation modelling. Findings This paper identifies a bundle of helpful brand actions – providing relevant topics and ideas; approaching content with a problem solving orientation; as well as investing in efforts to interpret, analyse and explain topics through …