Search results for "H1"
showing 10 items of 1219 documents
Quality assurance of decision-making in conversations between professionals and non-professionals: identifying the presence of deliberative principles
2012
The ideal of dialogue is at stake in professional conversations. The aim of this study is to develop an instrument that makes it possible to compare principles of deliberation with what actually takes place in professional conversations. The developed instrument is tested on one patient's conversation with his doctor about lifestyle changes, and meetings where pupils with learning disabilities and their parents discuss further schooling with school representatives. Although in need of refinement, the conclusion is that the instrument provides meaningful insight into how much each participant 'contributes' to the decision-making process and 'behaves' during the conversation.
El Profesor universitario y su función docente
2014
La labor del profesorado es clave para desarrollar el nuevo modelo educativo. Al profesor, le corresponde iniciar tanto la función educativa que introduzca y forme al alumno en la disciplina técnica objeto de estudio, como la función formativa, tendente a preparar al estudiante para desenvolverse debidamente tanto en el terreno profesional como humano. Así, el profesor debe potenciar la orientación al aprendizaje de sus alumnos, realizar un seguimiento cercano de la evolución de sus habilidades y conocimientos corrigiendo, en caso necesario, las posibles desviaciones. Debe desarrollar planes formativos para conseguir una profundización en el tratamiento de las competencias, en su evaluación…
Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours
2019
BACKGROUND: Interferon-induced expression of programmed cell death ligands (PD-L1/PD-L2) may sustain tumour immuneevasion. Patients featuring MET amplification, a genetic lesion driving transformation, may benefit from anti-MET treatment. We explored if MET-targeted therapy interferes with Interferon-gamma modulation of PD-L1/PD-L2 in MET-amplified tumours.METHODS: PD-L1/PD-L2 expression and signalling pathways downstream of MET or Interferon-gamma were analysed in MET-amplified tumour cell lines and in patient-derived tumour organoids, in basal condition, upon Interferon-gamma stimulation, and after anti-MET therapy.RESULTS: PD-L1 and PD-L2 were upregulated in MET-amplified tumour cells up…
Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation.
2021
Significance Multiple sclerosis (MS) is a neuroinflammatory, demyelinating disease that represents one of the most frequent causes of irreversible disability in young adults. Treatment options to halt disability are limited. We discovered that T helper (Th)17 cells in contact with oligodendrocytes produce higher levels of glutamate and induce significantly greater oligodendrocyte damage than their Th2 counterpart. Blockade of CD29, which is linked to glutamate release pathways and expressed in high levels on Th17 cells, preserved human oligodendrocyte processes from Th17-mediated injury. Our data thus provide evidence for the direct and deleterious attack of Th17 cells on the myelin compart…
Unirationality of Hurwitz spaces of coverings of degree <= 5
2011
Let $Y$ be a smooth, projective curve of genus $g\geq 1$ over the complex numbers. Let $H^0_{d,A}(Y)$ be the Hurwitz space which parametrizes coverings $p:X \to Y$ of degree $d$, simply branched in $n=2e$ points, with monodromy group equal to $S_d$, and $det(p_{*}O_X/O_Y)$ isomorphic to a fixed line bundle $A^{-1}$ of degree $-e$. We prove that, when $d=3, 4$ or $5$ and $n$ is sufficiently large (precise bounds are given), these Hurwitz spaces are unirational. If in addition $(e,2)=1$ (when $d=3$), $(e,6)=1$ (when $d=4$) and $(e,10)=1$ (when $d=5$), then these Hurwitz spaces are rational.
Putative high mobility group non-histone chromosomal proteins from pea (Pisum sativum)
1991
Abstract Three putative HMG proteins, 1P, 2P and 3P have been isolated from pea ( Pisum sativum L. cv. Lincoln) nuclei by extraction with either 5% perchloric acid or 0.35 M NaCl and purified by preparative electrophoresis. The amino acid analysis showed many of the typical features of the HMG proteins, although 1P and 2P possess a somewhat reduced content of acidic amino acids and 3P has less than 20% basic amino acids. Peptide mapping with Staphylococcus aureus V8 protease suggested that none of the proteins are proteolytic products of histone H1.
Vaccination with TAT-Antigen Fusion Protein Induces Protective, CD8+ T Cell-Mediated Immunity Against Leishmania Major
2010
In murine leishmaniasis, healing is mediated by IFN-γ-producing CD4 + and CD8 + T cells. Thus, an efficacious vaccine should induce Th1 and Tc1 cells. Dendritic cells (DCs) pulsed with exogenous proteins primarily induce strong CD4-dependent immunity; induction of CD8 responses has proven to be difficult. We evaluated the immunogenicity of fusion proteins comprising the protein transduction domain of HIV-1 TAT and the Leishmania antigen LACK ( Leishmania homolog of receptors for activated C kinase), as TAT-fusion proteins facilitate major histocompatibility complex class I-dependent antigen presentation. In vitro , TAT–LACK-pulsed DCs induced stronger proliferation of Leishmania -specific C…
Effect of ketotifen on the bronchodilation induced by salbutamol.
1988
Twelve subjects with stable asthma each inhaled two puffs (200 micrograms) of salbutamol on 2 separate days 3 h after double-blind oral administration of ketotifen (two 1-mg capsules) or identical placebo. FEV1 was recorded before and at intervals for 4 h after inhalation of salbutamol. Overall, the FEV1 was significantly greater during the 4-hour period after premedication with ketotifen (p less than 0.02) and the difference between the effect of placebo and ketotifen was statistically significant at 120, 180 and 240 min after salbutamol (p less than 0.05).
Divergent effects of biolistic gene transfer in a mouse model of allergic airway inflammation.
2007
Particle-mediated epidermal delivery (PMED) of allergen genes efficiently prevents systemic sensitization and suppresses specific immunoglobulin E synthesis. We investigated in a mouse model of allergic airway disease the effect of PMED on the elicitation of local inflammatory reactions in the lung. BALB/c mice were biolistically transfected with plasmids encoding beta-galactosidase (betaGal) as model allergen under control of the DC-targeting fascin promoter and the ubiquitously active cytomegalovirus promoter, respectively. Mice were challenged intranasally with betaGal-protein with or without intermediate sensitization with betaGal adsorbed to aluminiumhydroxide. Subsequently, local cyto…
On the birational geometry of the universal Picard variety
2010
We compute the Kodaira dimension of the universal Picard variety P_{d,g} parameterizing line bundles of degree d on curves of genus g under the assumption that (d-g+1,2g-2)=1. We also give partial results for arbitrary degrees d and we investigate for which degrees the universal Picard varieties are birational.