Search results for "H30"
showing 10 items of 1587 documents
Periodic Classification of Local Anaesthetics (Procaine Analogues)
2006
Algorithms for classification are proposed based on criteria (information entropyand its production). The feasibility of replacing a given anaesthetic by similar ones in thecomposition of a complex drug is studied. Some local anaesthetics currently in use areclassified using characteristic chemical properties of different portions of their molecules.Many classification algorithms are based on information entropy. When applying theseprocedures to sets of moderate size, an excessive number of results appear compatible withdata, and this number suffers a combinatorial explosion. However, after the equipartitionconjecture, one has a selection criterion between different variants resulting fromc…
A statistical analysis of the three-fold evolution of genomic compression through frame overlaps in prokaryotes
2007
Abstract Background Among microbial genomes, genetic information is frequently compressed, exploiting redundancies in the genetic code in order to store information in overlapping genes. We investigate the length, phase and orientation properties of overlap in 58 prokaryotic species evaluating neutral and selective mechanisms of evolution. Results Using a variety of statistical null models we find patterns of compressive coding that can not be explained purely in terms of the selective processes favoring genome minimization or translational coupling. The distribution of overlap lengths follows a fat-tailed distribution, in which a significant proportion of overlaps are in excess of 100 base…
Targeted Therapy Modulates the Secretome of Cancer-Associated Fibroblasts to Induce Resistance in HER2-Positive Breast Cancer
2021
The combination of trastuzumab plus pertuzumab plus docetaxel as a first-line therapy in patients with HER2-positive metastatic breast cancer has provided significant clinical benefits compared to trastuzumab plus docetaxel alone. However, despite the therapeutic success of existing therapies targeting HER2, tumours invariably relapse. Therefore, there is an urgent need to improve our understanding of the mechanisms governing resistance, so that specific therapeutic strategies can be developed to provide improved efficacy. It is well known that the tumour microenvironment (TME) has a significant impact on cancer behaviour. Cancer-associated fibroblasts (CAFs) are essential components of the…
Multidisciplinary approach to characterize archaeological materials and status of conservation of the Roman thermae of reggio Calabria Site (Calabria…
2020
This multidisciplinary research focuses on diagnostic investigations to characterize the archaeological materials, as well as the alteration and degradation forms detected at the Roman Thermae of Reggio Calabria (Calabria, South Italy) site. The thermal complex, (dating I–II century B.C.), was built around three main rooms such as the caldarium (hot bath), the tepidarium (warm bath) and the frigidarium (cold bath), all connected to a central room through several entrances. The central hall still preserves a suggestive mosaic floor dating between the II and III century A.D., characterized by geometric motifs and black and white tesserae. Fragments of various archaeological stone materials, s…
Measuring the Regional Incidence of Taxes and Public Expenditure: The Available Methodology and its Limitations
2014
This article reviews the basic methodology used to estimate the regional incidence of taxes and public expenditure, which we call the fiscal incidence approach, and compares it with the cash flow approach, which measures tax revenues and expenditures in terms of the associated monetary cash flows. In this context, it considers critically the particular version of the cash flow approach used in Spain. The article also looks at the different ways in which economists have tried to decompose fiscal balances into a structural or distributive component and a cyclical component, and critically reviews present practices.
Short-Time Ocular Ischemia Induces Vascular Endothelial Dysfunction and Ganglion Cell Loss in the Pig Retina
2019
Visual impairment and blindness are often caused by retinal ischemia-reperfusion (I/R) injury. We aimed to characterize a new model of I/R in pigs, in which the intraocular pathways were not manipulated by invasive methods on the ocular system. After 12 min of ischemia followed by 20 h of reperfusion, reactivity of retinal arterioles was measured in vitro by video microscopy. Dihydroethidium (DHE) staining, qPCR, immunohistochemistry, quantification of neurons in the retinal ganglion cell layer, and histological examination was performed. Retinal arterioles of I/R-treated pigs displayed marked attenuation in response to the endothelium-dependent vasodilator, bradykinin, compared to sham-tre…
Pathogenesis and molecular mechanisms of anderson–fabry disease and possible new molecular addressed therapeutic strategies
2021
Anderson–Fabry disease (AFD) is a rare disease with an incidenceof approximately 1:117,000 male births. Lysosomal accumulation of globotriaosylceramide (Gb3) is the element characterizing Fabry disease due to a hereditary deficiency α-galactosidase A (GLA) enzyme. The accumulation of Gb3 causes lysosomal dysfunction that compromises cell signaling pathways. Deposition of sphingolipids occurs in the autonomic nervous system, dorsal root ganglia, kidney epithelial cells, vascular system cells, and myocardial cells, resulting in organ failure. This manuscript will review the molecular pathogenetic pathways involved in Anderson–Fabry disease and in its organ damage. Some studies reported that i…
Rheological and Flocculation Analysis of Microfibrillated Cellulose Suspension Using Optical Coherence Tomography
2018
A sub-micron resolution optical coherence tomography device was used together with a pipe rheometer to analyze the rheology and flocculation dynamics of a 0.5% microfibrillated cellulose (MFC) suspension. The bulk behavior of the MFC suspension showed typical shear thinning (power-law) behavior. This was reflected in a monotonously decreasing floc size when the shear stress exceeded the yield stress of the suspension. The quantitative viscous behavior of the MFC suspension changed abruptly at the wall shear stress of 10 Pa, which was reflected in a simultaneous abrupt drop of the floc size. The flocs were strongly elongated with low shear stresses. With the highest shear stresses, the flocs…
Registros de sanguijuelas de Costa Rica y clave para la identificación de las especies con redescripción de Cylicobdella costaricae Records of leeche…
2012
En contraste con los enormes esfuerzos realizados por caracterizar la fauna y flora de Costa Rica, con excepción de algunos registros aislados, muy poco se sabe sobre las sanguijuelas (Annelida: Clitellata) en este país. En este trabajo, presentamos la redescripción de una especie terrestre muy poco conocida: Cylicobdella costaricae, caracterizando su morfología externa e interna; esta última se mantenía completamente desconocida hasta la fecha. Adicionalmente, presentamos la primera lista de especies de sanguijuelas para Costa Rica con un total de 12 taxones registrados en las 7 provincias del país. Se incluye una breve descripción de su morfología, fotografías y localidades para cada taxó…
Functional evaluation of a “lingual ring” oral device applied on patients affected by temporo-mandibular disorders tmds: A comparative clinical trial
2021
This study aims to evaluate the functional variations of the electromyographic response and clinical symptomatology in TMD patients. This study has been performed and compared before and after the application of a therapeutic protocol based on the use of an oral device working on the proper mandibular repositioning through the proprioceptive-based lingual re-education called “Lingual Ring”. Between January to December 2016, 32 TMD patients have been recruited out of a series of 321 individuals recruited at the Neurosensorial and Motorial Surgery Department, in Palermo (Italy). All the patients underwent the Surface Electromyography (sEMG) of Masseter and Temporal muscles, with different reg…