Search results for "HAp"

Rational design of a fluopyram hapten and preparation of bioconjugates and antibodies for immunoanalysis

2015

A fluopyram hapten was designed in which insignificant electronic and structural modifications were foreseen and all potentially interacting chemical moieties were maintained. This hapten was prepared by total synthesis and three immunologically active bioconjugates were obtained and characterized. High-affinity and specific antibodies to fluopyram were raised.

Contribution of Extracellular Vesicles and Molecular Chaperones in Age-Related Neurodegenerative Disorders of the CNS

2023

Many neurodegenerative disorders are characterized by the abnormal aggregation of misfolded proteins that form amyloid deposits which possess prion-like behavior such as self-replication, intercellular transmission, and consequent induction of native forms of the same protein in surrounding cells. The distribution of the accumulated proteins and their correlated toxicity seem to be involved in the progression of nervous system degeneration. Molecular chaperones are known to maintain proteostasis, contribute to protein refolding to protect their function, and eliminate fatally misfolded proteins, prohibiting harmful effects. However, chaperone network efficiency declines during aging, prompt…

Estimation of Solute-Stationary Phase and Solute-Mobile Phase Interactions in the Presence of Ionic Liquids

2019

The presence of free silanols on alkyl-bonded reversed-phase stationary phases is responsible for broad and asymmetrical peaks when basic drugs are chromatographed with conventional octadecylsilane (C18) columns due to ionic interactions. In the last few years, ionic liquids (ILs) have attracted attention to reduce this undesirable silanol activity. ILs should be considered as dual modifiers (with a cationic and anionic character), which means that both cations and anions are able to adsorb on the stationary phase, creating a positively or negatively charged layer, depending on the relative adsorption. The accessibility of basic compounds to the silanols is prevented by both the IL cation a…

Ant crickets and their secrets: Myrmecophilus acervorum is not always parthenogenetic (Insecta: Orthoptera: Myrmecophilidae)

2021

Abstract Previously considered as a thelytokous parthenogenetic species, the widespread ant cricket Myrmecophilus acervorum actually turns out to have a mixed reproductive system: our recent surveys in the central part of its distribution area has revealed the presence of both sexes. Detailed morphological and morphometric descriptions of the previously unknown males are here provided. New data on species distribution in south-eastern Europe are presented, including the first records of M. balcanicus in Bulgaria and of M. nonveilleri in Bulgaria and Hungary. Phylogenetic and phylogeographic analyses have revealed several haplotypes of M. acervorum in Europe, with six of them forming a parth…

In Search for an Integrated Design Basis for Audio and Haptics

2008

Audio and haptics as interaction modalities share properties, which make them highly appropriate to be handled within a single conceptual framework. This paper outlines such framework, gaining ingredients from the literature concerning cross-modal integration and embodied cognition. The resulting framework is bound up with a concept of physical embodiment, which has been introduced within several scientific disciplines to reveal the role of bodily experience and the corresponding mental imagery as the core of meaning-creation. In addition to theoretical discussion, the contribution of the proposed approach in design is outlined.

Functionality of endothelial cells on silk fibroin nets: Comparative study of micro- and nanometric fibre size

2007

Biomimetic material design, such as mimicking nanostructured components of the extracellular matrix, is an actual challenge for biomaterial research with a high impact on tissue engineering and regenerative medicine. Thus, understanding the cellular response at the cell biological and molecular level and the consequences of various chemically or physically modified biomaterials is highly important. In the present study we assessed the response of human umbilical vein endothelial cells (HUVEC) and outgrowth endothelial cells (OEC) from endothelial progenitor cells to different variants of nanofibrous silk fibroin nets in comparison to microfibrous silk fibroin scaffolds with regard to cellul…

El happening y la creación de situaciones en dos novelas de Julio Cortázar espacios de liberación y metáfora de la escritura

2013

In his 60’s theoretical texts Julio Cortázar wrote about the happening as an avant-garde and radical practice. He underlined as well the difficulties of the 60’s intelligentsia to conceptualize it properly. His novels 62. Modelo para armar and Libro de Manuel experimented with the structure of happening as a model for narrative exploration. In fact, Cortázar used the happening and the debordian idea of situation for giving a possible answer to the main debate about the relationship between critical intelligentsia and political activity.

Data mining-based statistical analysis of biological data uncovers hidden significance: clustering Hashimoto’s thyroiditis patients based on the resp…

2014

The pathogenesis of Hashimoto's thyroiditis includes autoimmunity involving thyroid antigens, autoantibodies, and possibly cytokines. It is unclear what role plays Hsp60, but our recent data indicate that it may contribute to pathogenesis as an autoantigen. Its role in the induction of cytokine production, pro- or anti-inflammatory, was not elucidated, except that we found that peripheral blood mononucleated cells (PBMC) from patients or from healthy controls did not respond with cytokine production upon stimulation by Hsp60 in vitro with patterns that would differentiate patients from controls with statistical significance. This "negative” outcome appeared when the data were pooled and ana…

Muutos ostoprosessiin arpojen siirtyessä internetiin : case: Veikkaus

2005

Online Communities and Gambling Behaviors : a Systematic Review

2022

Abstract Purpose of Review The internet and virtual environments have enabled the formation of online communities around a variety of interests. Online communities focused on gambling are increasingly popular and attract users to interact and share ideas and experiences with likeminded others. This study reviews evidence from the latest research examining the role of online communities in gambling behaviors and gambling problems. Recent Findings A systematic literature search resulted in 17 studies. Research shows that online communities are used for diverse reasons like discussing gambling experiences and problems, sharing tips, and celebrating winnings with others. These reasons of online…