Search results for "HCl"

showing 10 items of 24 documents

The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds

2021

Mucus forms an important protective barrier that minimizes bacterial contact with the colonic epithelium. Intestinal mucus is organized in a complex network with several specific proteins, including the mucin-2 (MUC2) and the abundant IgGFc-binding protein, FCGBP. FCGBP is expressed in all intestinal goblet cells and is secreted into the mucus. It is comprised of repeated von Willebrand D (vWD) domain assemblies, most of which have a GDPH amino acid sequence that can be autocatalytically cleaved, as previously observed in the mucins MUC2 and mucin-5AC. However, the functions of FCGBP in the mucus are not understood. We show that all vWD domains of FCGBP with a GDPH sequence are cleaved and …

0301 basic medicineMUC5AC mucin-5ACMUC2 mucin-2 (Muc2 mouse)vWF von Willebrand factorBiochemistryvon Willebrand domainchemistry.chemical_compoundPVDF polyvinylidene difluorideMiceCricetinaeDisulfidesIntestinal MucosaPeptide sequenceEndoH endoglycosidase HbiologyChemistryrespiratory systemGDPH Gly-Asp-Pro-HisChaotropic agentBiochemistryWB Western blotIodoacetamideGuHCl guanidinium chlorideResearch ArticleIgG immunoglobulin GvWD von Willebrand D domainCHO CellsCHO Chinese hamster ovary03 medical and health sciencesEndoglycosidase HCricetulusProtein Domainsmucusvon Willebrand FactorAnimalsHumansintestinal epitheliumMolecular BiologyintestineFCGBP IgGFc-binding protein (Fcgbp mouse)GAPH Gly-Ala-Pro-HisMucin-2030102 biochemistry & molecular biologycolonBinding proteinEndoplasmic reticulumMucinITH3 inter-alpha-trypsin inhibitor heavy chain 3Cell BiologyMucusMice Inbred C57BL030104 developmental biologyMUC2Proteolysisbiology.proteinImmunoglobulin G (IgG)IAA iodoacetamideCell Adhesion MoleculesdisulfideThe Journal of Biological Chemistry
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Thermomineral waters of Greece: geochemical characterization

2020

75 °C). In terms of pH most results vary from 5.5 to 823 °C) ii) warm (23 40 °C) iii) thermal (40 75 °C) and iv) hyperthermal (&gtfew springs show either very low pH (&lt10) proposing serpentinization processes. Regarding TDS concentrations collected waters can be subdivided into low salinity (up to 1.5 g/L) brackish (up to 20 g/L) and saline (up to 43 g/L). The medium high salinities can be justified by mixing with sea water and/or strong waterrock interaction processes. Isotope composition of O and H ranges from 12.7 to +2.7 ‰ SMOW and from 91 to +12 ‰ SMOW respectively and is generally comprised between the Global Meteoric Water Line and the East Mediterranean Meteoric Water Line. Only few water samples show a positive shift for δ18O possibly related to high temperature waterrock interaction processes. Carbon dioxide (18 997000 μmol/mol) or N2 (1100 989000 μmol/mol) or CH4 (&ltMany geothermal areas of Greece are located in regions affected by Miocene or Quaternary volcanism and in continental basins characterised by elevated heat flow. Moreover the majority of them is found along the coast as well as in islands of the Aegean Sea and thus thermal water is often brackish to saline due to marine intrusion into costal aquifer. In the present study almost 300 thermal and cold mineral water samples were collected along the Hellenic territory with their physicochemical parameters (temperature pH electrical conductivity and Eh) and the amount of bicarbonates (titration with 0.1N HCl) being determined in situ. Additionally gases found either in free or dissolved phase were sampled. Both water and gas samples were analysed at the INGVPa laboratories for major ions (Ion Chromatography) silica (Inductively Coupled Plasma Optical Emission Spectrometry) chemical composition of free and dissolved gases (Gas Chromatography) water isotopes (O and H) and carbon and helium isotopes of free and dissolved gases (Mass Spectrometry). The temperature of the investigated waters ranges from 6.5 to 98°C pH from 1.96 to 11.98 whilst Total Dissolved Solids (TDS) from 0.06 to 43 g/L. Based on the temperature parameter waters can be divided into four groups: i) cold (&lt0.5 913000 μmol/mol) are the prevailing gas species found in the studied sites. The δ13CCO2 values ranged from 20.1 to +8.5 ‰ whilst the isotope ratio of He from 0.21 to 6.71 R/RA.4) suggesting interaction with H2Srich gases or very high pH values (&gtSettore GEO/08 - Geochimica E Vulcanologia
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Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor

2014

Brain mitochondrial activity is centrally involved in the central control of energy balance. When studying mitochondrial functions in the brain, however, discrepant results might be obtained, depending on the experimental approaches. For instance, immunostaining experiments and biochemical isolation of organelles expose investigators to risks of false positive and/or false negative results. As an example, the functional presence of cannabinoid type 1 (CB1) receptors on brain mitochondrial membranes (mtCB1) was recently reported and rapidly challenged, claiming that the original observation was likely due to artifact results. Here, we addressed this issue by directly comparing the procedures…

CB1 receptorWIN WIN55212-2Cannabinoid receptorBrain bioenergeticsLactate dehydrogenase Amedicine.medical_treatmentSDHADMSO dimethyl sulfoxideMitochondrionBiologySlp2 stomatin-like protein 2SDHA succinate dehydrogenase aTechnical ReportmedicineantibodieseducationReceptorKO knock-outMolecular Biologyeducation.field_of_studyelectron microscopyLDHa lactate dehydrogenase aDAB–Ni Ni-intensified 33ʹ-diaminobenzidine–4HClCell BiologySubcellular localizationWT wild-typemitochondriaBiochemistryCB1 cannabinoid type 1 receptorBSA bovine serum albuminCannabinoidorganelle purificationNeuroscienceImmunostainingMolecular Metabolism
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Status of the EU DEMO HCLL breeding blanket design development

2018

International audience; In the framework of the European “HORIZON 2020” innovation and research programme, the EUROfusion Consortium develops a design of a fusion power demonstrator (DEMO). One of the key components in the fusion reactor is the Breeding Blanket (BB) surrounding the plasma, ensuring tritium self-sufficiency, heat removal for conversion into electricity, and neutron shielding. CEA-Saclay, with the support of Wigner-RCP and Centrum výzkumu Řež, is in charge of the development of one of the four BB concepts investigated in Europe for DEMO: the Helium Cooled Lithium Lead (HCLL) BB. The rationales of the HCLL are the use of Eurofer as structural material, eutectic liquid lithium-…

Computer scienceNuclear engineeringBlanketBreeding7. Clean energy01 natural sciences010305 fluids & plasmasTritium breeding ratio0103 physical sciencesGeneral Materials Science010306 general physicsDEMOSettore ING-IND/19 - Impianti NucleariCivil and Structural EngineeringBreeding BlanketHelium gasMechanical EngineeringFusion power[INFO.INFO-MO]Computer Science [cs]/Modeling and SimulationCoolantNuclear Energy and EngineeringElectromagnetic shieldingHCLLBlanketMaterials Science (all)Design evolution
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Mixed MHD convection and Tritium transport in fusion-relevant configurations

2005

Mixed MHD flow and Tritium transport were computed for a slender poloidal duct, representative of a DEMO HCLL blanket element. 2-D flow and temperature fields were computed in the duct's cross section under the assumption of parallel, fully developed flow, while Tritium concentration C was found by solving a fully 3-D problem with simplifying assumptions at the duct's ends. The spatial distribution of C depended on the intensity and direction of the forced flow. Significant peak factors were obtained if the net flow rate was so low that re-circulation occurred; C maxima were attained near the walls for upward flow, in the core region for downward flow.

ConvectionPhysicsMechanical EngineeringHCLL blanketMechanicsBlanketFusion powerMagnetohydrodynamicVolumetric flow ratePhysics::Fluid DynamicsNuclear physicsNuclear Energy and EngineeringCombined forced and natural convectionFlow conditioningGeneral Materials ScienceDuct (flow)Mixed convectionMagnetohydrodynamicsSettore ING-IND/19 - Impianti NucleariCivil and Structural Engineering
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On the nuclear response of the helium-cooled lithium lead test blanket module in ITER

2005

Abstract The helium-cooled lithium lead (HCLL) concept has been recently selected as one of the two European reference designs foreseen for the breeding blanket of a demonstration fusion reactor. In particular, within the framework of the research and development activities on this blanket line, an HCLL test blanket module (TBM) has to be designed and manufactured to be implemented in ITER. At the Department of Nuclear Engineering (DIN) of the University of Palermo, a research campaign has been carried out to investigate the nuclear response of HCLL-TBM inside ITER by a numerical approach based on the Monte Carlo method. A realistic 3D heterogeneous model of HCLL-TBM has been set-up and ins…

CryostatMaterials scienceMechanical EngineeringNuclear engineeringMonte Carlo methodchemistry.chemical_elementBlanketFusion powerNuclear Energy and EngineeringchemistryTest blanket moduleHCLL-blanketNeutronicsRadiation damageNeutron sourceGeneral Materials ScienceLithiumSettore ING-IND/19 - Impianti NucleariHeliumCivil and Structural EngineeringFusion Engineering and Design
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Study of the helium-cooled lithium lead test blanket module nuclear behaviour under irradiation in ITER

2009

Abstract The present paper deals with the detailed investigation of the helium-cooled lithium lead test blanket module (HCLL-TBM) nuclear behaviour under irradiation in ITER, carried out at the Department of Nuclear Engineering of the University of Palermo adopting a numerical approach based on the Monte Carlo method. A realistic 3D heterogeneous model of the HCLL-TBM was set-up and inserted into an ITER 3D semi-heterogeneous model that realistically simulates the reactor lay-out up to the cryostat. A Gaussian-shaped neutron source was adopted for the calculations. The main features of the HCLL-TBM nuclear response were assessed, paying a particular attention to the neutronic and photonic d…

CryostatNeutron transportTokamakMaterials scienceMechanical EngineeringNuclear engineeringchemistry.chemical_elementFusion powerBlanketHCLL test blanket module Neutronics Monte Carlo methodlaw.inventionNuclear physicsNuclear Energy and EngineeringchemistrylawNeutron sourceGeneral Materials ScienceLithiumSettore ING-IND/19 - Impianti NucleariHeliumCivil and Structural EngineeringFusion Engineering and Design
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Eurofusion-DEMO Divertor - Cassette Design and Integration

2020

International audience; The Eurofusion-DEMO design will complete the Pre Conceptual Design phase (PCD) with a PCD Gate, named G1, scheduled to take place in Q4 2020 that will focus on assessing the feasibility of the plant and its main components prior to entering into the Conceptual Design phase. In the paper first an overview is given of the Eurofusion-DEMO Divertor Assembly including design and interface description, systems and functional requirements, load specification, system classification, manufacturing procedures and cost estimate. Then critical issues are discussed and potential design solutions are proposed, e.g.:- Neutron material damage limits of the different (structural) mat…

DEMO; Divertor; CAD DesignMaterials sciencePassive coolingNuclear engineeringPort (circuit theory)01 natural sciences7. Clean energy010305 fluids & plasmas[SPI]Engineering Sciences [physics]DivertorConceptual design0103 physical sciencesDEMO fusion reactorGeneral Materials ScienceCAD Design010306 general physicsDEMOnuclear fusionSettore ING-IND/19 - Impianti NucleariCivil and Structural Engineeringelectromagnetic computationToroidNuclear heatingSeparatrixMechanical EngineeringDivertornuclear fusion plasma control electromagnetic computationNuclear Energy and EngineeringTUNGSTEN/EUROFER COATING SYSTEM CONCEPTUAL DESIGN COOLING CIRCUIT PROGRESS HCLLplasma controlHigh heat
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A Monte Carlo study on the possible lay-out influence in the HCLL-TBM nuclear response

2008

HCLL-TBM NeutronicsSettore ING-IND/19 - Impianti Nucleari
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Diffusion dialysis for HCl and heavy metals separation from highly concentrated pickling solutions

2019

Disposal of pickling waste solutions strongly affects hot-dip galvanizing industries’ economics and environmental footprint. Thus, the recovery of acid is an important step to enhance the process sustainability. Diffusion dialysis (DD) can be used to separate acids and heavy metals (e.g. iron and zinc) from pickling waters, promoting the circular use of such raw materials. In the present work, two DD modules, a laboratory scale unit operating in batch and a continuous operated large unit, equipped with Fumasep anionic exchange membranes were tested. Results obtained show that zinc and iron affect HCl recovery in opposite way, however reaching high recovery values. In particular, zinc consid…

Industrial waste recoveryHeavy metalAEMIronModelingPickling proceHClDiffusion dialysi
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