Search results for "HD"

IκB kinase-driven nuclear factor-κB activation in patients with asthma and chronic obstructive pulmonary disease.

2011

Background Nuclear factor-κB (NF-κB) is a transcriptional factor of different inflammatory patterns involved in asthma and chronic obstructive pulmonary disease (COPD) that is tightly controlled by IκB kinase (IKK) complex. Objective We investigated the dysregulation of IKK-driven NF-κB activation in patients with asthma and COPD. Methods We assessed IKKα and IKKβ expression and activation, their regulation by glucocorticosteroids, and their involvement in IL-8 synthesis in PBMCs isolated from asthmatic patients, healthy smokers (HSs), patients with COPD, and control subjects. PBMCs from control subjects were stimulated with TNF-α and cigarette smoke extract in the presence or absence of fl…

Inflammatory Biomarkers in Elite Cross-Country Skiers After a Competition Season : A Case-Control Study

2022

Abstract Purpose Whether elite athletes, who have been exposed to vigorous-intensity exercise combined with other stressors, have elevated systemic low-grade inflammation, remains largely unclear. To address this question, we studied the levels of six inflammatory cytokines as potential biomarkers of a low-grade inflammatory state in elite athletes after an 11-month training and competition season. Methods We collected sera from 27 Finnish elite cross-country skiers and 27 gender- and age-matched, moderately-exercising controls. The serum concentrations of C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), glycoprotein acetyls (GlycA), interleukin 10 (IL-10…

Modulation of lipid metabolism and colonic microbial diversity of high-fat-diet C57BL/6 mice by inulin with different chain lengths

2019

Abstract The physicochemical properties, biological functions and microbial degradation of inulins differ according to their degree of polymerization. However, the relationship between inulin activities and its effect on gut microbiota remains unknown. In this study, high fat diet with inulin (1 or 5 g/kg·bw), either with short or long chains groups were administered to different groups of mice (n = 10) for 10 weeks in order to investigate the effect of inulin on the microbial diversity of the animals. Litchi pericarp procyanidins (LPPC) were used for comparison purposes. Furthermore, the lipid metabolism and key regulator genes in mice were determined. The results indicated that natural in…

Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms - Findings from Helsinki Birth …

2021

Background: Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present study evaluated associations between AGEs, depressive symptoms, and types of depressive symptoms. Methods: From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive…

Comparative study of the lubricant performance of Compritol® HD5 ATO and Compritol® 888 ATO: effect of polyethylene glycol behenate on lubricant capa…

2003

The aim of this paper is to study the lubricant capacity of Compritol HD5 ATO, a glyceryl and polyethylene glycol dibehenate, obtained by atomization. This material is compared to Compritol 888 ATO, constituted only by glyceryl dibehenate. First, this study verifies that Compritol HD5 ATO and Compritol 888 ATO present the same granular characteristics and that their mixes with Lactopress present no structural differences. Secondly, in term of compressibility and cohesiveness, the use of Compritol 888 ATO or Compritol HD5 ATO with Lactopress does not involve any significant modification. Finally, the minor difference of lubricant capacity between Compritol HD5 ATO and Compritol 888 ATO has n…

Taistelu huomisen Kuubasta : Amerikan kuubalaisyhteisön diasporisen identiteetin ilmeneminen tapauksessa Elián Gonzalez

2003

The Risk Society: Towards a new modernity

2009

The present review discusses one of the pioneer projects authored by Ulrich Beck, regarding risk perception issues, which was originally titled Risikogesellshaft, Auf dem weg in eine andere Moderne or in English The society of risk, towards a new modernity. This review is part of a broader project related to a Social Psychology doctoral thesis on fears of travelling in urban circumstances.

Everolimus With Reduced Tacrolimus Improves Renal Function in De Novo Liver Transplant Recipients: A Randomized Controlled Trial

2012

    In a prospective, multicenter, open-label study, de novo liver transplant patients were randomized at day 30±5 to (i) everolimus initiation with tacrolimus elimination (TAC Elimination) (ii) everolimus initiation with reduced-exposure tacrolimus (EVR+Reduced TAC) or (iii) standard-exposure tacrolimus (TAC Control). Randomization to TAC Elimination was terminated prematurely due to a higher rate of treated biopsy-proven acute rejection (tBPAR). EVR+Reduced TAC was noninferior to TAC Control for the primary efficacy endpoint (tBPAR, graft loss or death at 12 months posttransplantation): 6.7% versus 9.7% (-3.0%; 95% CI -8.7, 2.6%; p<0.001 for noninferiority [12% margin]). tBPAR occurred in…

Graphical THD minimization procedure for single phase five-level converters

2017

This paper proposes two graphycal procedure to mitigate h harmonics and to minimize the total harmonic distortion (THD), respectively. The paper considers a five-level inverter and fundamental frequency modulation: it computes the two switching angles able to reduce low order harmonics and able to minimize the THD. Simulation results are obtained and, in order to validate the proposed procedure, an experimental prototype is built and experimental results are carried out. The comparison between simulation and experimental results confirms the accuracy of the proposed graphycal procedure. It is shown that the switching angles to mitigate the third-fifth and the third-fifth-seventh harmonics e…

Soziale Integration und deren Bedeutung für die Lebensqualität nach Laryngektomie

2013

Soziale Netzwerke und gesellschaftliche Teilhabe wirken sich im Allgemeinen positiv auf das psychische Befinden aus. Inwiefern Patienten nach einer Kehlkopfentfernung wieder in die Gesellschaft eingebunden werden, ist jedoch wenig untersucht. Ziel der Studie war es, zu prufen, inwieweit Patienten nach einer Laryngektomie sozial integriert sind und ob die soziale Integration mit bestimmten Bereichen der Lebensqualitat zusammenhangt. In einer multizentrischen Studie wurden 161 Patienten ein Jahr nach Laryngektomie befragt. Die soziale Integration wurde anhand eines Index erhoben. Dieser setzt sich aus Fragen zur sozialen Unterstutzung und dem Fragenkomplex zur Einbindung in die Gesellschaft, …