Search results for "HEE"

Temperature effects explain continental scale distribution of cyanobacterial toxins

2018

Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect…

Influence of Nanoparticle Exposure on Nervous System Development in Zebrafish Studied by Means of Light Sheet Fluorescence Microscopy

2016

Zebrafish has a remarkable similarity in the molecular signaling processes, cellular structure, anatomy and physiology to other higher order vertebrates, making it an excellent vertebrate model organism (1). Recently, zebrafish has been used for neurotoxicity screening of numerous nanomaterials with a focus on the developmental effects due to the possibility of in vivo visualization of specific neurons and axon tracts by injecting dyes in live animals as well in fixed ones (2). Here we propose Light Sheet Fluorescence Microscopy (LSFM) (3) (4) to perform neurotoxicity studies, in order to study the nervous system architecture and to image 3D structures in the brain of live larvae during the…

A Novel Fast Volumetric Light Sheet Microscopy

2016

Fast noninvasive three-dimensional (3D) imaging is crucial for the quantitative understanding of highly dynamic biological processes. Over the last decades, several fluorescence microscopy techniques have been developed in order to provide a faster and deeper imaging of thick biological samples [1]. Within this framework, Light Sheet Fluorescence Microscopy (LSFM) has emerged as a powerful imaging tool for 3D imaging of thick samples ranging from single cells to entire animals [2,3].However, to obtain a 3D reconstruction either sample or microscope parts usually need to be moved limiting the acquisition speed and inducing possible interferences in volume recording. To solve this problem, he…

Ligniinin osuuden vaikutus ligniini-fenoliformaldehydihartsien kemiaan

2017

Fenoliformaldehydihartsia valmistetaan fenolista ja formaldehydistä, joka toimii ristisilloitusagenttina. Katalyyttinä käytetään natriumhydroksidia. Formaldehydi liittyy fenolin renkaaseen hydroksyyliryhmän para- tai orto-asemiin additioreaktiolla alkalisissa olosuhteissa. Fenolin alkalointi saa aikaa renkaaseen karbanioneja, joihin formaldehydin elektrofiilinen hiiliatomi voi liittyä. Reaktio tunnetaan Lederer-Manasse-reaktiona. Ligniini on amorfinen biopolymeeri, jota saadaan esimerkiksi sulfaattiprosessin sivutuotteena. Rakenteellisesti ligniinistä voidaan erottaa kolme fenyylipropaaniyksikköä, jotka ovat p-kumaryylialkoholi, koniferyylialkoholi ja sinapyylialkoholi. Ligniinillä voidaan …

Effect of consumers’ origin on perceived sensory quality, liking and liking drivers: A cross-cultural study on European cheeses

2021

Abstract We aim at studying consumers’ Perceived Sensory Quality (PSQ) concept. We manipulated a priori both familiarity (contrast local vs. foreign cheeses) and quality level (contrast PDO or traditional cheeses vs. their non-PDO and/or industrial counterpart). The study was run in four European countries. Thus, eight cheeses (one PDO or traditional cheese and one non-PDO cheese from each of the four European countries) were assessed by a total of 438 consumers (from 100 to 120 consumers from each region) in terms of PSQ and liking. The cheeses were also described by a trained panel. PSQ depended on both consumers’ and cheeses’ origin. The main finding is that in the three countries with P…

Longitudinal Stability of Reading Difficulties : Examining the Effects of Measurement Error, Cut-Offs, and Buffer Zones in Identification

2020

This study examined the stability of reading difficulties (RD) from grades 2 to 6 and focused on the effects of measurement error and cut-off selection in the identification of RD and its stability with the use of simulations. It addressed methodological limitations of prior studies by (a) applying a model-based simulation analysis to examine the effects of measurement error and cut-offs in the identification of RD, (b) analyzing a non-English and larger sample, and (c) examining RD in both reading fluency and reading comprehension. Reading fluency and reading comprehension of 1,432 Finnish-speaking children were assessed in grades 2 and 6. In addition to the use of single cut-off points on…

Poliittinen siivekäs : lintujen konkreettisuus suomalaisessa 1970-luvun ympäristörunoudessa

2010

Suomalaisen luontorunouden maisema on aina ollut linnuista rikas. Siivekkäitä ihaillaan runoudessa usein etäällä lentävinä, tai lintu paljastuu jonkun inhimillisen tunteen tai toiveen vertauskuvaksi. 1970-luvulla suomalaisen runouden lintukuvauksessa tapahtui muutos. Linnut tulivat lukijan lähelle kouriintuntuvasti mutta silti eläimellisen vierautensa säilyttäen. Ne alkoivat myös kärsiä ympäristöongelmista todellisten lintujen tavoin. Poliittinen siivekäs on ekokriittisiä ja posthumanistisia teorioita yhdistävä tutkimus lintujen konkretisoitumisesta, siitä miten linnuista alettiin kirjoittaa lintuina. Suomalaisten runoilijoiden ympäristötietoista linturunoutta suhteutetaan runoutemme tradit…

Kuvien maaseutu : maaseutumaisemakuvaston luomat mielikuvat suomalaisesta maaseutukulttuurista

2013

Node co-activations as a means of error detection : Towards fault-tolerant neural networks

2022

Context: Machine learning has proved an efficient tool, but the systems need tools to mitigate risks during runtime. One approach is fault tolerance: detecting and handling errors before they cause harm. Objective: This paper investigates whether rare co-activations – pairs of usually segregated nodes activating together – are indicative of problems in neural networks (NN). These could be used to detect concept drift and flagging untrustworthy predictions. Method: We trained four NNs. For each, we studied how often each pair of nodes activates together. In a separate test set, we counted how many rare co-activations occurred with each input, and grouped the inputs based on whether its class…

Triacylglycerol Analysis in Human Milk and Other Mammalian Species: Small-Scale Sample Preparation, Characterization, and Statistical Classification …

2015

In this work, a method for the separation of triacylglycerols (TAGs) present in human milk and from other mammalian species by reversed-phase high-performance liquid chromatography using a core–shell particle packed column with UV and evaporative light-scattering detectors is described. Under optimal conditions, a mobile phase containing acetonitrile/n-pentanol at 10 °C gave an excellent resolution among more than 50 TAG peaks. A small-scale method for fat extraction in these milks (particularly of interest for human milk samples) using minimal amounts of sample and reagents was also developed. The proposed extraction protocol and the traditional method were compared, giving similar results…