Search results for "HIF"
showing 10 items of 1515 documents
Przestrzenne zmiany w strukturze produkcji rolnej w Unii Europejskiej
2016
Wiele zachodzących zjawisk, ich rozwój czy też kierunki zmian, uzależnione są od przestrzennych interakcji zachodzących pomiędzy sąsiadującymi regionami. Model przestrzennej analizy shift-share, który został wprowadzony do badań przez Nazarę i Hewingsa, przedstawia przestrzennie zmodyfikowane stopy wzrostu (tempa zmian) poszczególnych wariantów zjawiska przez uwzględnienie temp wzrostu zjawiska w obszarach sąsiadujących. Celem artykułu jest analiza zmian struktury towarowej produkcji rolnej w krajach Unii Europejskiej według wybranych rodzajów produktów rolnych z zastosowaniem przestrzennej metody przesunięć udziałów. W opracowaniu dokonano oceny tempa zmian wielkości zjawiska oraz zidentyf…
Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy
2020
AbstractThe current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat COVID-19. A particularly important aspect is the development of medication. In addition to viral proteins, structured RNA elements represent a potent alternative as drug targets. The search for drugs that target RNA requires their high-resolution structural characterization. Using nuclear magnetic resonance (NMR) spectroscopy, a worldwide consortium of NMR researchers aims to characterize potential RNA drug targets of SCoV2. Here, we report the characterization of 15 conserved RNA elements located at the 5′ end, the ribosomal frameshift segment and t…
Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.
2003
Dysregulation of extracellular matrix turnover is an important feature of many inflammatory processes. Rat renal mesangial cells express high levels of matrix metalloproteinase 9 (MMP-9) in response to inflammatory cytokines such as interleukin-1 beta. We demonstrate that NO does strongly destabilize MMP-9 mRNA, since different luciferase reporter gene constructs containing the MMP-9 3' untranslated region (UTR) displayed significant reduced luciferase activity in response to the presence of NO. Moreover, by use of an in vitro degradation assay we found that the cytoplasmic fractions of NO-treated cells contained a higher capacity to degrade MMP-9 transcripts than those obtained from contro…
Analysis of involvement of the 3?-untranslated regions in regulating mRNA stability for vitellogenin, cyanoprotein ?, and cyanoprotein ? from the bea…
2002
The degradation of the 3'-untranslated regions (UTRs) of vitellogenin, cyanoprotein alpha, and cyanoprotein beta from the bean bug, Riptortus clavatus, was analyzed in vitro. The degradation pattern was similar for all three RNAs, with a high degradation rate in non-diapausing adult insects and no degradation in the fifth instar nymphs and in diapausing adults, and was not correlated with the expression levels of these three proteins. Proteins binding to the 3'-UTRs were detected in polysomal and cytosolic extracts. These factors, however, were present in all developmental stages. The abundance of the polysomal factor showed little variation, but the cytosolic factor was enriched in adult i…
Effetti spaziali o settoriali? La crescita della dimensione media d'impresa in Italia
2015
Utilizzando una recente versione della shift-share con struttura spaziale, in questo contributo scomponiamo il cambiamento della dimensione media delle imprese nelle province italiane rispetto a componenti di natura sia spaziale (di regione e di vicinato) che settoriale. L’analisi, condotta con riferimento al periodo 2004-2009, mette in risalto differenze di rilievo rispetto la classe dimensionale considerata. In particolare, si registra una netta demarcazione Nord-Sud nella distribuzione provinciale degli effetti spaziali e settoriali se consideriamo le micro imprese (1-10 addetti), mentre la geografia appare molto piu complessa per le piccole imprese (11-50 addetti).
Cities, hinterlands and agglomeration shadows: spatial developments in Finland over 1880-2004
2011
This paper analyzes long-term spatial developments in Finland by focusing on two predictions of the new economic geography (NEG) models, the increasing persistence of locational patterns and the emerging agglomeration shadow, i.e. the rising dominance of growth centers. Pre- and post-war periods are distinguished to roughly express the shift from an agriculture-based economy to a post-industrial country. The analyses base on the assumption that each of the 19 Finnish regions has a center of its own and the rest of the region forms its local hinterland. The empirical analysis is based on regional population data from 1880 to 2004 at decade intervals. First, to analyze the persistence of loca…
Sadalīšanās produktu noteikšana Bikarfen 50mg tabletēs, izmantojot AEŠH metodi
2020
Literatūras apskatā apkopota informācija par Bikarfen 50 mg tablešu sastāvu, izmantošanu farmācijā un to aktīvi farmaceitisko vielu - sehifenadīna hidrohlorīdu. Aprakstīti degradācijas pētījumi, to pieejamās vadlīnijas un veidi – hidrolīze, oksidēšana, termiska apstrāde un fotolīze. Darbā ir apkopota informācija par augsti efektīvās šķidrumu hromatogrāfijas (AEŠH) metodes validāciju. Darba eksperimentālajā daļā tika veikta Bikarfen 50 mg tablešu, Bikarfen 50 mg tablešu placebo un sehifenadīna hidrohlorīda degradācija ar skābi, bāzi un ūdeņraža peroksīdu. Analizējamo paraugu degradācijas pētījumi tika veikti arī “saules” gaismā, mitrumā un paaugstinātā temperatūrā. Iegūtie degradācijas produ…
Insights into the catalytic production of hydrogen from propane in the presence of oxygen: Cooperative presence of vanadium and gold catalysts
2015
7 figures.-- © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
The hypoxia-inducible factor-responsive proteins semaphorin 4D and vascular endothelial growth factor promote tumor growth and angiogenesis in oral s…
2012
Growth and metastasis of solid tumors requires induction of angiogenesis to ensure the delivery of oxygen, nutrients and growth factors to rapidly dividing transformed cells. Through either mutations, hypoxia generated by cytoreductive therapies, or when a malignancy outgrows its blood supply, tumor cells undergo a change from an avascular to a neovascular phenotype, a transition mediated by the hypoxia-inducible factor (HIF) family of transcriptional regulators. Vascular endothelial growth factor (VEGF) is one example of a gene whose transcription is stimulated by HIF. VEGF plays a crucial role in promoting tumor growth and survival by stimulating new blood vessel growth in response to suc…
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.
2010
Inflammation drives expression of VEGFR2, which is expressed on and drives growth of tumor cells in colitis-associated cancer.