Search results for "HIV"
showing 10 items of 1527 documents
An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines
2020
Abstract: Herein, we report further improvements to the synthesis of tenofovir 1, the precursor to tenofovir disoproxil fumarate and tenofovir alafenamide fumarate. Starting from acyclic precursor diaminomalononitrile 12, a four-step protocol to tenofovir 1 will allow for vertical integration for more manufacturers. The key transformation is a more convergent one step procedure from 6 as compared to the current commercial process, with an improved yield from 59% (two steps) to 70%. Further improvements include eliminating the need for problematic magnesium tert-butoxide (MTB) and significant solvent reduction by eliminating the need for an intermediate workup. With the costs of HIV/AIDS tre…
Acceptability of dual HIV/syphilis rapid test in community- and home-based testing strategy among transgender women in Buenos Aires, Argentina.
2021
Background: Little is known of acceptability and feasibility of dual HIV and syphilis rapid tests in community- and home-based provider-initiated strategies among transgender women (TGW), in Latin America. Objectives were (1) to assess the acceptability of this strategy and, (2) to determine the percentage of positive results of HIV and syphilis, analyze the correlates of HIV or syphilis positive results, and measure the rates of effective referral and treatment completion among TGW. Methods: A multidisciplinary team tested 89 TGW in Buenos Aires. An acceptability survey was administered after the HIV/syphilis Duo test was used. All confirmed cases were referred for treatment initiation. R…
Le incognite dei testamenti: nemesi storica in casa Moncada
2011
L’esame dei testamenti di Matteo Moncada e dei figli, Guglielmo Raimondo e Antonio, legati alle ultime volontà dell’antenato Matteo Sclafani, permette di ricostruire e seguire la storia di una famiglia e della contea di Adernò e Centorbi.
The Finnish Open Science and Research Initiative and Development of Green Open Access in Finland
2016
Presentation in Slovakian Open Government Week, Bratislava, 19.10.2016
The metabolic syndrome and HIV infection.
2013
The metabolic syndrome (MetS), a cluster of risk factors for cardiovascular disease and type 2 diabetes, has become an important public health problem. Considerable differences in the prevalence of the MetS in human immunodeficiency virus (HIV)-infected subjects have been reported, as a consequence of several limitations regarding the diagnostic critera for MetS. New evidence suggests that the use of optimal waist cut-off points specific for the various ethnic populations could represent a step forward in overcoming these limitations. Also the use of specific cut-off points for measuring upper trunk fat as an adjunctive criterion of MetS in HIV patients with lipodystrophy could represent an…
L'intonaco Li Vigni nell'architettura del XX secolo a Palermo. Nuove conoscenze e applicazioni diagnostiche per la manutenzione
2013
Il saggio presenta lo studio degli intonaci formulati per imitare le pietre e i marmi naturali che si diffondono in Sicilia all’inizio del XX secolo ed evidenzia che le prime applicazioni e la diffusione delle nuove malte, anche nel resto dell’Italia, risentono delle sperimentazioni condotte in tutta l’Europa. Il contributo riassume i risultati di una rigorosa e capillare ricognizione tra i brevetti conservati presso l’Archivio Centrale dello Stato a Roma inerenti alle malte per il confezionamento dell’intonaco a “finta pietra”, ne analizza i contenuti in modo critico e pone in risalto i contatti culturali con le sperimentazioni dei materiali in atto nell’ambito dei grandi cantieri di resta…
Una storia italiana: Giorgio e Isabella
2018
Si tratta, qui, della storia di due italiani dalla “pelle scura” raccontata, per Giorgio Marincola, da Carlo Costa e Lorenzo Teodonio in Razza partigiana e, per la sorella Isabella, da Wu Ming 2 e Antar Mohamed in Timira. Romanzo meticcio. Le loro vicende, così come molti altri aspetti della nostra storia coloniale, neocoloniale e postcoloniale, sono riemerse dal buio nel quale erano state occultate solo nell’ultimo quindicennio, grazie alla riapertura degli archivi che ha permesso di ridiscutere molti degli aspetti che nelle pagine di Storia, così come in quelle letterarie, erano stati raccontati in altro modo. I due testi, che hanno inevitabilmente finito per incontrarsi e che potremmo in…
Una tabla inédita de Fernando Yáñez y nueva luz sobre su estancia en Almedina (1518-1525)
2020
The contribution presents a new acquisition for the catalog of Fernando Yáñez, a Holy Family dating back to 1523, shedding new light on the artist?s production in the third decade of the sixteenth century during his return to Almedina, his birthplace, in a time frame that divides the works for Valencia, like the retablo mayor for the city?s cathedral, from his altarpieces for Cuenca.
Tusa: i cosidetti Bagni-Balnea in contrada Gravina
2020
Il presente contributo presenta lo studio condotto sul complesso archeologico noto come Bagni, sito nel Comune di Tusa (ME), sulla costa tirrenica, a circa 2 km dall’antico centro di Alesa Arconidea.
NFAT transcription factors control HIV-1 expression through a binding site downstream of TAR region.
2004
NFAT factors control HIV-1 transcription. We show here that, in addition to binding to two NF-kappaB/NFAT sites within the U3 HIV LTR, NFATc1 and NFATc2 bind to an NFAT site within the LTR's U5 region. Mutations in this site which abolish NFAT binding reduce the ability of NFATs to transactivate LTR-mediated transcription. Mutations in all three NFAT sites strongly interfered with LTR induction, but affected moderately the stimulatory effect of Tat.