Search results for "HOMA"

Glofitamab (Glofit) in Combination with Polatuzumab Vedotin (Pola): Phase Ib/II Preliminary Data Support Manageable Safety and Encouraging Efficacy i…

2021

Abstract Background: Glofit is a novel, CD20xCD3 T-cell-engaging bispecific antibody that provides monovalent binding to CD3 on T cells and bivalent binding to CD20 on B cells. As monotherapy, Glofit has shown promising response rates with manageable safety in R/R B-cell non-Hodgkin lymphoma (B-NHL) patients (pts; [Carlo-Stella et al. EHA 2021]). Because of their distinct and complementary mechanism of action, there is a rationale for combining Glofit with the anti-CD79b-targeted antibody-drug conjugate, Pola. NP39488 (NCT03533283) is a Phase Ib/II, open-label, multicenter, dose-escalation (DE) and expansion study evaluating Glofit + Pola or atezolizumab in R/R B-NHL pts (Hutchings et al. A…

Hepatosplenic γδ T-cell lymphoma: complete response induced by treatment with pentostatin

2002

Galvaskausa lūzuma cēloņi, komplikācijas un ārstēšanas iespējas bērniem

2018

Darba pamatojums. Galvaskausa lūzumus izraisa tiešs trieciens pa kalvāriju, un visbiežāk tiek skarti velves kauli. Traumas visbiežāk rodas sadzīves negadījumos, piemēram, kritieni no ķermeņa augstuma vai tieša objekta krietiena uz galvas. Visbiežāk tiek skarts paura un pakauša kauls. Ļoti bieži sastopamas galvaskausa lūzumu komplikācijas, visbiežāk raksturīgas hematomas un smadzeņu satricinājums. Ķirurģisku iejaukšanos veic ļoti sarežģītos gadījumos, tāpēc konservatīva terapija tiek izmantota biežāk. Darba mērķis: Noskaidrot biežākos galvaskausa lūzuma iemeslus, vecumu kādā tiek gūtas traumas, izraisītās komplikācijas un ārstēšanas metodes bērniem līdz 18 gadiem Latvijā. Materiāli un metode…

Pleiotropic antitumor effects of the pan-HDAC inhibitor ITF2357 against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas,

2014

Histone deacetylases (HDAC) extensively contribute to the c-Myc oncogenic program, pointing to their inhibition as an effective strategy against c-Myc-overexpressing cancers. We, thus, studied the therapeutic activity of the new-generation pan-HDAC inhibitor ITF2357 (Givinostat®) against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas (B-NHLs). ITF2357 anti-proliferative and pro-apoptotic effects were analyzed in B-NHL cell lines with c-Myc translocations (Namalwa, Raji and DOHH-2), stabilizing mutations (Raji) or post-transcriptional alterations (SU-DHL-4) in relationship to c-Myc modulation. ITF2357 significantly delayed the in vitro growth of all B-NHL cell lines by inducing G1 c…

Description of a Simple, Specific, and Sensitive Test for the Detection of Detergent-Solubilized C3b Receptor

1981

Abstract The C3b receptor was isolated from detergent-solubilized human erythrocyte membranes by a previously described technique (1). The receptor glycoprotein was shown to enhance EAC14oxy23b rosette formation with Raji lymphoblastoid cells. This provided a specific and sensitive test to detect the solubilized C3b receptor either in crude or highly purified form. The property of the C3b receptor tested by this assay appears to be analogous to properties of β1H.

On the aromaticity of uracil and its 5-halogeno derivatives as revealed by theoretically derived geometric and magnetic indexes

2020

AbstractThe problem of aromaticity in heterocyclic rings of uracil and its 5-halogenoderivatives (5XU) was analyzed theoretically by calculating modified harmonic oscillator model of aromaticity (HOMA) for Heterocycle Electron Delocalization (HOMHED), nucleus-independent chemical shift parameters (NICS) and the so-called scan experiments, using helium-3 atom as a magnetic probe. The impact of halogen electronegativity on C5 atom’s NBO charges was also investigated. Water, as a polar environment, has a negligible impact on 5XU aromaticity. The most stable diketo tautomer shows a very low aromaticity while the “rare” dihydroxy form (tautomer No 6) is aromatic and resembles benzene. This is in…

Sir Thomas More's Utopia : An overlooked economic classic

2019

Sir Thomas More's Utopia, published in 1516, is a classic work of how to organise a society based on common property. With a unique mix of common property, institutions and sound economic insights, we argue that More built a framework for a society that could be viable in the long run. While the conditions that make Utopia work are quite restrictive, it does provide a sketch of a society where common property may not stifle long‐term development, but is associated with productive workers and people content with their lives. peerReviewed

Bleomycin, a selective inhibitor of DNA-dependent DNA polymerase from oncogenic RNA viruses.

1972

Abstract Bleomycin, an antibiotic, inhibits the DNA-dependent DNA polymerase from Rauscher murine leukemia virus. Higher concentrations of BLM ∗ are required to inhibit it's RNA-dependent DNA polymerase. These inhibition effects of the non-competitive type are not altered by preincubation of the DNA with BLM. Under comparable conditions neither the DNA-dependent DNA polymerase activity from E. coli and mouse liver nor the DNA-dependent RNA polymerase activity from mouse lymphoma cells are affected by BLM.

L’espace dans Der einzige Ort de Thomas Stangl : pour une circulation des modèles culturels et identitaires ?

2016

International audience; Dans son roman Der einzige Ort (2004), l’écrivain autrichien contemporain Thomas Stangl s’attache aux dichotomies de « l’ici et de l’ailleurs » et du « soi et de l’Autre » dans une perspective déconstructiviste et postcoloniale.L’espace en tant que motif littéraire et que catégorie poétologique y occupe une place centrale car il permet à l’auteur d’esquisser un bouleversement identitaire qui trouve sa source dans de nouvelles interactions entre le sujet et ce qui lui est à l’origine étranger.Parallèlement, Stangl fait de l’acte narratif une topographie complexe et ouverte sur l’Ailleurs.

Substituent effects in nitro derivatives of carbazoles investigated by comparison of low-temperature crystallographic studies with density functional…

2014

The crystal structure of 9H-carbazole, C12H9N, (I), has been redetermined at low temperature for use as a reference structure in a comparative study with the structures of 1-nitro-9H-carbazole, C12H8N2O2, (II), and 9-nitrocarbazole, C12H8N2O2, (III). The molecule of (I) has crystallographically imposed mirror symmetry (Z′ = 0.5). All three solid-state structures are slightly nonplanar, the dihedral angles between the planes of the arene and pyrrole rings ranging from 0.40 (7)° in (III) to 1.82 (18)° in (II). Nevertheless, a density functional theory (DFT) study predicts completely planar conformations for the isolated molecules. To estimate the influence of nitro-group substitution on aroma…