Search results for "HRI"
showing 10 items of 2945 documents
The Source Value of Arabic Typikon-Manuscripts as Testimonials for the Byzantinization of the Melkites
2021
With the expansion of Islam, the patriarchates of Antioch, Jerusalem, and Alexandria were divided from the Byzantine Empire. The Orthodox Christians there still defined themselves as Byzantine Orthodox and began to adapt their liturgical customs by adopting Byzantine liturgical books. When Greek was not understood any longer, they began to translate and copy their liturgical books, thereby creating their own branch of tradition, which is marked by multilingualism, reception of their own Bible tradition as well as the exclusion of “neo-martyrs” from their calendar of saints.
Innovation and Entrepreneurial Ecosystems: Structure, Boundaries, and Dynamics
2019
Recognizing the broader dimensions of entrepreneurial and innovation activities, holistic and inclusive networked approaches pave the way to co-creation activities that are essential for achieving sustainability in food systems. Recent studies have started to deepen what are the critical enablers for creating thriving entrepreneurial and innovation ecosystems. Networks that include firms, institutions, and several other relevant stakeholders in knowledge spillovers enable to produce more social and economic value through co-creation processes. However, due to the unique complexity within ecosystems, there is no standardized framework or strategy to develop entrepreneurial or innovation ecos…
Orthodoxy and Evangelicalism: An Overview of Their Relationship from the Perspective of Moral Values
2021
Orthodox–Evangelical relationships are dominated by proselytism (at least in Eastern Europe and in the former Soviet Union). This is understood as church conversion practiced through unfair means among people who are already Christians, belonging to so-called “historical churches.” However, beyond it, there is a real potential for cooperation using moral values as a starting point. As there is an increasing disagreement between the Orthodox and mainline Protestant on moral values, the Orthodox and Evangelicals might increase their cooperation as they witness traditional values of Christianity. This kind of cooperation might be partially contextual, but it is based on Biblicism, which both O…
Value at risk : eksponentiaalisesti painotettu historiallinen simulaatio
2014
Tämän tutkimuksen tarkoituksena oli toteuttaa Value at Risk-malleja vertaileva backtesting-tutkimus. Malleiksi valikoituivat perinteinen painottamaton historiallinen simulaatio ja eksponentiaalisesti painotettu historiallinen simulaatio. Tavoitteena oli tutkia kannattaako havaintoja painottaa koska molemmat mallit olivat siinä mielessä vertailukelpoisia, että painotettu malli toteutettuna painotuskertoimella 1, eli kaikki havainnot saavat saman painon vastaa painottamatonta variaatiota. Lähtökohtana oli, että painottaminen on kannattavaa koska painottamattomassa versiossa pienillä havaintomäärillä havaintojoukko ei ole edustava ja suurilla havaintomäärillä taas malli ei kykene huomioimaan m…
L'Evangelium Nicodemi e le traduzioni romanze
2015
L’Evangelium Nicodemi è uno degli apocrifi più diffusi nel medioevo occidentale. Il racconto della Passione di Cristo, collegato allo spaccato del Descensus Christi ad inferos, ha avuto un grande successo, testimoniato non solo dall’ampia tradizione manoscritta del vangelo latino ma anche dalle numerose traduzioni volgari di cui fu oggetto, dai rimaneggiamenti e dalle riprese in altri testi. La diffusione dell’Evangelium Nicodemi ha determinato l’introduzione di particolari topoi nell’orizzonte mentale del medioevo europeo. A differenza degli studi riguardanti le aree extraromanze, solo da pochi anni la Romanistica ha mostrato un rinnovato interesse per le traduzioni dell’apocrifo nicodemia…
Chapter 13 Antiphospholipid Antibodies and Vasculitis
2009
Abstract Besides the large group of primary vasculitis diseases, vasculitis in autoimmune diseases is most commonly associated with systemic lupus erythematosus (SLE), scleroderma, rheumatoid arthritis, insulin-dependent diabetes mellitus, and dermatomyositis. The antiphospholipid syndrome (APS), as a relatively recently recognized autoimmune disorder, may also present with a variety of vasculitis features. These non-typical vasculitis syndromes have to be considered very carefully in the APS, and vasculitis manifestations presenting as systemic involvement in APS patients have to be identified very early to prevent patients from rapidly developing organ damage. The aim of this review artic…
Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?
2016
Endothelial Progenitor Cells (EPCs) are bone marrow derived cells able to differentiate in mature endothelial cells (EC) contributing to the generation of new vessels, connecting to fibronectin, and forming colonies and/or colony forming units. Since circulating EPCs can be actively considered part of endothelial damage in several cardiovascular diseases and autoimmune disorders the possibility to have a measure for endothelium damage should be considered of interest to predict the patient out-come. At the same time the EPCs proliferative and regenerative role could be considered for therapeutic applications. Studies have been performed to elucidate the role of EPCs in Systemic Sclerosis an…
DNASE1L3 deficiency, new phenotypes, and evidence for a transient type I IFN signaling.
2022
Background: Deoxyribonuclease 1 like 3 (DNASE1L3) is a secreted enzyme that has been shown to digest the extracellular chromatin derived from apoptotic bodies, and DNASE1L3 pathogenic variants have been associated with a lupus phenotype. It is unclear whether interferon signaling is sustained in DNASE1L3 deficiency in humans. Objectives: To explore interferon signaling in DNASE1L3 deficient patients. To depict the characteristic features of DNASE1L3 deficiencies in human. Methods: We identified, characterized, and analyzed five new patients carrying biallelic DNASE1L3 variations. Whole or targeted exome and/or Sanger sequencing was performed to detect pathogenic variations in five juvenile …
Angiotensin II Type 1 Receptor Antibodies Are Higher in Lupus Nephritis and Vasculitis than Other Glomerulonephritis Patients
2022
AbstractAngiotensin II type 1 receptor (AT1R) antibodies are considered non-HLA (human leukocyte antigen) antibodies connected with humoral rejection after kidney transplantation. The role of AT1R antibodies in the pathogenesis of glomerular diseases and systemic vasculitis is unknown. We assessed the level of AT1R antibodies in 136 patients with different types of glomerulonephritis and systemic vasculitis and we observed kidney function and proteinuria, serum albumin and total protein levels for 2 years. The mean levels of AT1R antibodies were the following: 6.00 ± 1.31 U/ml in patients with membranous nephropathy (n = 18), 5.67 ± 1.31 U/ml with focal and segmental glomerulosclerosis (n =…
Extrahepatic Morbidity and Mortality of Chronic Hepatitis C
2015
Chronic hepatitis C virus (HCV) infection is associated with several extra-hepatic manifestations. Patients with HCV may develop mixed cryoglobulinemia and its sequelae, ranging from cutaneous and visceral vasculitis to glomerulonephritis and B cell non-Hodgkin’s lymphoma. HCV-infected patients have increased rates of insulin resistance, diabetes and atherosclerosis, which may lead to increased cardiovascular morbidity and mortality. Neurologic manifestations of HCV infection include fatigue and cognitive impairment. The mechanisms causing the extra-hepatic effects of HCV infection are likely multifactorial and may include endocrine effects, HCV replication in extra-hepatic cells, or a heig…