Search results for "HRI"

Primārās un sekundārās modelēšanas sistēmas dzejas tekstos: Mihaila Lotmana teorētiskās pieejas piemērošana

2016

Saskaņā ar Tartu-Maskavas semiotikas skolas idejām, dabiskā valoda veido primāro modelēšanas sistēmu, uz kuras pamata tiek konstruētas augstāka līmeņa kultūras sistēmas (sekundārās modelēšanas sistēmas). Mihails Lotmans ir pārskatījis klasisko modelēšanas teoriju, un saskaņā ar viņa piedāvāto teoriju primārās un sekundārās modelēšanas sistēmas ir relatīvas viena pret otru, un tajās jēdziens „valoda” tiek šķirts no jēdziena „semiotikas sistēma”. Esošā pētījuma mērķis ir piemērot semiotikas metodes, balstītas uz Mihaila Lotmana izveidotās struktūras, Eiropas un Āfrikas mītiski reliģiskajām modelēšanas sistēmām Nigērijas dzejnieka Kristofera Okigbo darbos. Pētījuma rezultāti rāda, ka šī strukt…

Die Wiederentdeckung der Bedeutung der Gebetsformel per Christum durch Josef Andreas Jungmann

2022

Już w Nowym Testamencie poświadczona modlitewna formuła per Christum – „przez Chrystusa” do IV w. należała do wspólnego dziedzictwa liturgicznego wszystkich chrześcijan. Geneza i znaczenie tej wyrażającej pośrednictwo Chrystusa w liturgicznej modlitwie formuły zostały gruntownie przebadane zarówno w aspekcie historycznym, jak i teologicznym przez J.A. Jungmanna. Wkład tego uczonego w ponowne odkrycie roli formuły per Christum jest przedmiotem niniejszego artykułu. Najpierw omówiono w nim niektóre wyniki wnikliwych badań historycznych przeprowadzonych przez Jungmanna, a następnie przedstawiono jego teologiczne interpretacje formuły. W ostatniej części została podjęta próba oceny badawczych d…

Ustekinumab therapy changes the transcriptional activity pattern of TGF-β1–3 genes

2019

Introduction One of the examples of genes whose expression can be altered by the action of ustekinumab is TGF-β. It is a pleiotropic cytokine whose activity affects psoriatic changes and the state of homeostasis of the whole organism. Aim To evaluate the effect of ustekinumab on the transcriptional activity of TGF-b family genes in patients with psoriatic arthritis and to check whether the results obtained can be helpful in monitoring the progress of treatment. Material and methods From total PBMCs obtained from peripheral blood of 14 patients with psoriatic arthritis, total RNA was isolated. The expression level of the TGF-β1, TGF-β2 and TGF-β3 genes was determined by RT-qPCR in real time.…

Warunki dobrego postu według wybranych pisarzy greckich IV-VI w

2020

Praktykowanie postu wśród wyznawców Jezusa Chrystusa należało do istotnych czynności ascetycznych już od pierwszych pokoleń chrześcijaństwa, ponieważ to zalecenie pojawiło się w nauczaniu Zbawiciela. Dlatego pasterze tamtych czasów na różne sposoby zachęcali członków swoich wspólnot do podjęcia okresowego postu, niezależnie od ich zróżnicowanego podejścia do jego przestrzegania. O obecności zagadnienia postu w życiu kościelnym tych wspólnot świadczą teksty homilii, mów i traktatów, w których zamieszczone są zachęty kierowane do wiernych opisujące sposoby przestrzegania zasad postu oraz jego uzdrawiające wartości. Do autorów, którzy zajmowali się tymi kwestiami, należeli m.in. Asteriusz z Am…

Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis

2019

Abstract Despite the advances in the treatment of rheumatoid arthritis (RA) achieved in the last few years, several patients are diagnosed late, do not respond to or have to stop therapy because of inefficacy and/or toxicity, leaving still a huge unmet need. Tissue-specific strategies have the potential to address some of these issues. The aim of the study is the development of a safe nanotechnology approach for tissue-specific delivery of drugs and diagnostic probes. CD34 + endothelial precursors were addressed in inflamed synovium using targeted biodegradable nanoparticles (tBNPs). These nanostructures were made of poly-lactic acid, poly-caprolactone, and PEG and then coated with a synovi…

Anti-senescence and Anti-inflammatory Effects of the C-terminal Moiety of PTHrP Peptides in OA Osteoblasts.

2016

Osteoarthritis (OA) is characterized by degenerative changes in the whole joint leading to physical disability in the elderly population. This condition is associated with altered bone metabolism in subchondral areas suggesting that therapeutic strategies aimed at modifying bone cell metabolism may be of interest. We have investigated the effects of several parathyroid hormone-related protein (PTHrP)-derived peptides (1-37): (N-terminal), (107-111) and (107-139) (C-terminal) on senescence features induced by inflammatory stress in human OA osteoblasts. Incubation of these primary cells with interleukin(IL)-1β led to an increased expression of senescence markers senescence-associated-β-galac…

Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases

2018

Since the discovery of HLA 60 years ago, it has contributed to the understanding of the immune system as well as of the pathogenesis of several diseases. Aside from its essential role in determining donor-recipient immune compatibility in organ transplantation, HLA genotyping is meanwhile performed routinely as part of the diagnostic work-up of certain autoimmune diseases. Considering the ability of HLA to influence thymic selection as well as peripheral anergy of T cells, its role in the pathogenesis of autoimmunity is understandable. The aim of this paper is to provide a brief overview of the role and current clinical relevance of HLA-B27 in spondyloarthritis and HLA-B51 in Behçet's disea…

THU0713 How the variation in the lumbopelvic patterns of movement affects the neuromotor control of the biceps femoris during trunk forward bending

2017

Background Trunk forward bending is one of the most common activities in daily living; it is a two-part movement involving the lumbar spine flexion and pelvis rotation at hip joint. The pattern of movement during forward bending was defined as the relative contribution of the lumbar spine to pelvis motion, and was expressed as the ratio between the ranges of lumbar spine motion to pelvis motion (L/P), which, calculated at certain degrees of trunk flexion during the entire movement, provides the lumbo-pelvic rhythm. This is associated with a specific pattern of activation for back and hip extensor muscles which was coined as flexion relaxation phenomenon, observed either in the erector spina…

2016

Objectives Human leukocyte antigen (HLA)-B27 (B27) is the strongest genetic factor associated with development of Ankylosing Spondylitis and other spondyloarthropathies (SpA), yet the role it plays in disease pathogenesis remains unclear. We investigated the expression of potentially pathogenic non-conventional heavy chain forms (NC) of B27 in synovial and intestinal tissues obtained from SpA patients. We also determined the presence of NC-B27 in joints, lymphoid and gastrointestinal tissue from B27 transgenic (TG1) rats with M.tuberculosis-induced SpA.

FRI0150 Mtor blockade by rapamycin decreases arthritis and spondylitis development and severity in hla-b27 transgenic rats

2018

Career situation of first and presenting author Student for a master or a PhD. Introduction TNF and IL-17A have been demonstrated as key inflammatory cytokines in Spondyloarthritis (SpA), whereas targeting bone remodeling remains an unmet clinical need in SpA. The mammalian target of rapamycin (mTOR) regulates IL-17 expression and osteogenesis and could therefore be a promising therapeutic target in SpA. Objectives To investigate if blockade of mTOR with rapamycin inhibits the pathological processes in inflammation and bone in SpA. Methods Cytokines were measured by ELISA in the supernatant from SpA patient PBMCs stimulated with anti-CD3/CD28, with various concentrations of rapamycin. SpA F…