Search results for "Harm"

Inelastic neutron scattering study of proton dynamics in Ca(OH)2 at 20 K

1995

Abstract Inelastic neutron scattering (INS) spectra of Ca(OH) 2 at 20 K are presented from 30 to 4000 cm −1 for a powder sample, from 30 to 12000 cm −1 for an oriented single-crystal. INS band splitting due to the lattice density-of-states is observed. Polarization effects reveal the orientation of atomic displacements for each mode and a new band assignment scheme is proposed. For the single-crystal, the v OH mode and overtones are observed. This oscillator shows only moderate anharmonicity. Spectrum simulation reveals that INS spectral intensities are not consistent with simple normal coordinates and harmonic force-fields for Ca(OH) 2 entities. A new dynamical model is proposed, including…

Harmonic morphisms in nonlinear potential theory

1992

This article concerns the following problem: given a family of partial differential operators with similar structure and given a continuous mapping f from an open set Ω in Rn into Rn, then when does f pull back the solutions of one equation in the family to solutions of another equation in that family? This problem is typical in the theory of differential equations when one wants to use a coordinate change to study solutions in a different environment.

2020

New soluble and intensely near-IR-absorbing transition metal (Ti, Zr, V, Ni) complexes were synthesized using a redox non-innocent N,N’-bis(3,5-di-tertbutyl-2-hydroxy-phenyl) -1,2-phenylenediamine (H4L) as a ligand precursor. In all the complexes, ([Ti(Lox)2, [Zr(Lox)2], [V(Lsq1)(HLox)] and [Ni(HLox)2], two organic molecules coordinate to the metal center as tri- or tetradentate ligands. The solid-state structures of the complexes were determined using single crystal XRD, and the compounds were further characterized with Electrospray Ionisation Mass Spectrometry (ESI-MS). Thermoanalytical measurements indicated the thermal stabilities of the complexes. All compounds absorb strongly in the n…

Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs)

2020

[Image: see text] Translational readthrough-inducing drugs (TRIDs) rescue the functional full-length protein expression in genetic diseases, such as cystic fibrosis, caused by premature termination codons (PTCs). Small molecules have been developed as TRIDs to trick the ribosomal machinery during recognition of the PTC. Herein we report a computational study to identify new TRID scaffolds. A pharmacophore approach was carried out on compounds that showed readthrough activity. The pharmacophore model applied to screen different libraries containing more than 87000 compounds identified four hit-compounds presenting scaffolds with diversity from the oxadiazole lead. These compounds have been s…

Fluorine-Containing Drugs Approved by the FDA in 2018

2019

Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atoms. In this review, we profile 17 fluorine-containing drugs approved by the food and drug administration (FDA) in 2018. The newly approved pharmaceuticals feature several types of aromatic F and CF3 , as well as aliphatic (CF2 ) substitution, offering advances in the treatment of various diseases, including cancer, HIV, malarial and smallpox infections.

Diabetes and renin-angiotensin-aldosterone system: Implications for covid-19 patients with diabetes treatment management

2020

In the context of the COVID-19 continuous spreading, this paper focuses on the increased risk of diabetic patients regarding the metabolic control and the uncertainties related to SARS-CoV-2 infection. Chronic hyperglycaemia negatively affects the immune system, which triggers an increase of morbidity and mortality for viral infections. A key aspect of COVID-19 resides in the involvement of renin-angiotensin-aldosterone (RAAS) system that causes a cascade of reactions mediated by vasoactive peptides with implications in vasoconstriction, vascular permeability, oxidative stress remodelling and tissue injuries. Activation of RAAS at pulmonary level, is responsible for the local damage. Many q…

Pharmaceuticals and other urban contaminants threaten Amazonian freshwater ecosystems

2021

Abstract Urban areas in the Brazilian Amazon have grown at an unprecedented rate during the last years. About 90% of the wastewater produced by these urban areas are discharged untreated into Amazonian freshwater ecosystems, constituting a potential environmental pathway for pharmaceuticals and other chemicals consumed by modern societies (e.g. psychostimulants, personal-care products, hormones). The distribution of these chemicals into the Amazon River and their potential risks for freshwater biodiversity have not been evaluated so far. Here, we show the results of the largest chemical monitoring campaign conducted in the Amazon region. We assessed exposure patterns for 43 pharmaceuticals …

Du Néolithique récent à l’âge du Bronze dans le Centre Nord de la France : les étapes de l’évolution chrono-culturelle

2011

Die seit 2001 im Rahmen eines PCR (Programme Collectif Régional) durchgeführte Gemeinschaftsarbeit über das Ende des Neolithikums und den Beginns der Bronzezeit im Zentrum Nordfrankreichs führt heute zu einer neuen Periodisierung der Zeit zwischen 3600 und 1800 v. Chr. in acht Etappen. Obwohl, insbesondere bezüglich der Transition zwischen dem Mittel-und dem Jungneolithikum einerseits und dem Jung-und dem Endneolithikum andererseits, auch weiterhin einige Lücken bestehen, erlaubt dieser präzisere Rahmen die Hauptetappen im Zentrum Nordfrankreichs mit denen der benachbarten Regionen zu synchronisieren, um eine dynamischere Vision der kulturellen Phänomene vorzuschlagen.

Dental microwear texture analysis on extant and extinct sharks : Ante- or post-mortem tooth wear?

2020

Sharks are apex-predators that play an important role in past and present aquatic food webs. However, their diet - especially in extinct species - is often not well constrained. Dental microwear texture analysis (DMTA) has been successfully applied to reconstruct diet and feeding behaviours of different aquatic and terrestrial vertebrates. However, unlike in mammals, food-to-tooth contact in sharks is rather limited because only larger prey is manipulated before swallowing. Together with a fast tooth replacement rate, this reduces wear on individual teeth. Here, we present an explorative study of dental microwear texture on extant and extinct sharks to test whether ante-mortem wear is relat…

La tombe à chars d'Évergnicourt (Aisne), "Le Tournant du Chêne"

2005

Lambot Bernard, Méniel Patrice. La tombe à chars d'Évergnicourt (Aisne), "Le Tournant du Chêne". In: Revue archéologique de Picardie. Numéro spécial 22, 2005. Hommages à Claudine Pommepuy. pp. 327-354.