Search results for "Hemin"
showing 10 items of 93 documents
Identification and characterisation of the dopamine receptor II from the cat flea Ctenocephalides felis (CfDopRII)
2006
International audience; G protein-coupled receptors (GPCRs) represent a protein family with a wide range of functions. Approximately 30% of human drug targets are GPCRs, illustrating their pharmaceutical relevance. In contrast, the knowledge about invertebrate GPCRs is limited and is mainly restricted to model organisms like Drosophila melanogaster and Caenorhabditis elegans. Especially in ectoparasites like ticks and fleas, only few GPCRs are characterised. From the cat flea Ctenocephalides felis, a relevant parasite of cats and dogs, no GPCRs are known so far. Thus, we performed a bioinformatic analysis of available insect GPCR sequences from the honeybee Apis mellifera, the mosquito Anop…
A Thermophilic Tetramolecular G-Quadruplex/Hemin DNAzyme.
2017
International audience; The quadruplex-based DNAzyme system is one of the most useful artificial enzymes or catalysts; their unique properties make them reliable alternatives to proteins for performing catalytic transformation. The first prototype of a thermally stable DNAzyme system is presented. This thermophilic DNAzyme is capable of oxidizing substrates at high temperatures (up to 95 degrees C) and long reaction times (up to 18 h at 75 degrees C). The catalytic activity of the DNAzymes were investigated with the standard peroxidase-mimicking oxidation of 2,2'-azino-bis(3-ethylbenzothiozoline-6-sulfonic acid) (ABTS) by H2O2. The step-by-step design of this unique heat-activated G-quadrup…
Hemin induces germ tube formation in Candida albicans.
1997
Hemin induced germination of Candida albicans blastoconidia when cells grown up to the early exponential phase were shifted from 28 to 37 degrees C (70 to 75% of cells exhibited germ tubes). N-Acetyl-D-glucosamine (GlcNAc), another inducer of myceliation in this fungus, caused a similar effect. The combination of hemin and GlcNAc resulted in a higher percentage (95%) of blastoconidial germination. These results suggest that in addition to temperature, hemin levels and carbon source may coordinately regulate the expression of subsets of genes involved in the yeast-to-mycelium transition in C. albicans.
Analyse de cheminement, effets directs et indirects de variables
2022
Inégalités territoriales dans l'accès à l'alternance : le cas des jeunes des QPV
2023
La syndicalisation des cheminots français. Fin ou résistance d’un « bastion ».
2013
International audience; Sans revenir sur les évolutions de la syndicalisation – tant en France ou, plus globalement, en Europe –, ni sur ses analyses, il apparaît que celle-ci aurait assez bien résisté dans le secteur ferroviaire, souvent présenté, dans le cas français à tout le moins, comme une sorte de « bastion » syndical, lequel est également invoqué pour expliquer la « combativité » des cheminots.On peut naturellement supposer que cette plus forte propension à « se mobiliser » est liée notamment à un niveau d’engagement syndical – notamment dans des organisations contestataires – qui resterait beaucoup plus élevé que dans les autres secteurs de l’économie. Ce n’est sans aucun doute pas…
Hierarchical Mass Transfer Analysis of Drug Particle Dissolution, Highlighting the Hydrodynamics, pH, Particle Size, and Buffer Effects for the Disso…
2020
Dissolution is a crucial process for the oral delivery of drug products. Before being absorbed through epithelial cell membranes to reach the systemic circulation, drugs must first dissolve in the human gastrointestinal (GI) tract. In vivo and in vitro dissolutions are complex because of their dependency upon the drug physicochemical properties, drug product, and GI physiological properties. However, an understanding of this process is critical for the development of robust drug products. To enhance our understanding of in vivo and in vitro dissolutions, a hierarchical mass transfer (HMT) model was developed that considers the drug properties, GI fluid properties, and fluid hydrodynamics. T…
Alkaline haematin D-575, a new tool for the determination of haemoglobin as an alternative to the cyanhaemiglobin method. I. description of the method
1984
A new method for the rapid and accurate measurement of haemoglobin has been developed as an alternative to the conventional cyanhaemiglobin method. This method is based on the conversion of all haeme, haemoglobin, and haemiglobin species into a stable end product by an alkaline solution of a non-ionic detergent ('AHD reagent'). The reaction product, designated as alkaline haematin D-575, is extremely stable and shows a characteristic absorption peak at 575 nm. As compared to the cyanhaemiglobin method, the determination of haemoglobin by alkaline haematin D-575 offers several advantages such as (1) extreme stability of the AHD reagent and the conversion product, (2) decreased conversion tim…
Quelle "citoyenneté industrielle" à la SNCF ? Premiers éléments
2019
International audience; Dans un contexte de transformation des règles de représentation syndicale et de la négociation collective, de reconfiguration des institutions représentatives du personnel, d’évolutions et de débats concernant la participation de représentants des salariés au sein des conseils d’administration et, plus au fond, d’évolution de la sociologie et du débat syndical mais aussi de réformes ferroviaires récurrentes, touchant notamment au statut du personnel, il est proposé d’examiner comment dans une entreprise, telle la SNCF, certains acteurs – en l’occurrence les organisations syndicales – mais aussi le (célèbre) « statut » du personnel appréhendent (ou pas) cette notion d…
De la régionalisation à la concurrence régulée. Analyse économique et juridique de la future organisation du transport ferroviaire régional de voyage…
2006
This paper deals with the introduction of competition for the market in French regional passenger railways. Following a double approach through economics and law, it discusses the proposals for a European regulation on public passenger transport services. In a first part, the paper explains the interest and limits of competition for the market concerning French regional rail services. After analyzing the German and Swedish cases, it proposes a way of introducing competition for the market in France. In a second part, structural reforms needed ex ante are analyzed: open access to stations, rolling stock availability and future of rail employees. For each reform, the theoretical analysis is f…